Low-grade glioma harbors few CD8 T cells, which is accompanied by decreased expression of chemo-attractants, not immunogenic antigens

Autor: Bas Weenink, Kaspar Draaisma, Han Z. Ooi, Johan M. Kros, Peter A. E. Sillevis Smitt, Reno Debets, Pim J. French

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)

Abstract In multiple tumor types, prediction of response to immune therapies relates to the presence, distribution and activation state of tumor infiltrating lymphocytes (TILs). Although such therapies are, to date, unsuccessful in gliomas, little is

Externí odkaz: https://doaj.org/article/8d69b7caf1204a69af1c62b11ef298e8

Data from Prognostic Significance of DNA Methylation Profiles at MRI Enhancing Tumor Recurrence: a Report from the EORTC 26091 TAVAREC Trial

Autor: Pim J. French, Martin J. van den Bent, Pierre A. Robe, Ahmed Idbaih, Thierry Gorlia, Vassilis Golfinopoulos, Corneel Coens, Tina Verschuere, Johan M. Kros, Olivier L. Chinot, Michael Weller, Martin J.B. Taphoorn, Paul J. Mulholland, Antje Wick, Filip Y.F. de Vos, Paul M. Clement, Jaap C. Reijneveld, Marion Smits, Martin Klein, Iris de Heer, C. Mircea S. Tesileanu, Kaspar Draaisma

Purpose:Despite recent advances in the molecular characterization of gliomas, it remains unclear which patients benefit most from which second-line treatments. The TAVAREC trial was a randomized, open-label phase II trial assessing the benefit of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532142765998775af1347106878dfffb
https://doi.org/10.1158/1078-0432.c.6532437

Transcriptome analysis reveals tumor microenvironment changes in glioblastoma

Autor: Youri Hoogstrate, Kaspar Draaisma, Santoesha A. Ghisai, Levi van Hijfte, Nastaran Barin, Iris de Heer, Wouter Coppieters, Thierry P.P. van den Bosch, Anne Bolleboom, Zhenyu Gao, Arnaud J.P.E. Vincent, Latifa Karim, Manon Deckers, Martin J.B. Taphoorn, Melissa Kerkhof, Astrid Weyerbrock, Marc Sanson, Ann Hoeben, Slávka Lukacova, Giuseppe Lombardi, Sieger Leenstra, Monique Hanse, Ruth E.M. Fleischeuer, Colin Watts, Nicos Angelopoulos, Thierry Gorlia, Vassilis Golfinopoulos, Vincent Bours, Martin J. van den Bent, Pierre A. Robe, Pim J. French

Publikováno v: Cancer Cell, 41(4)
Cancer Cell, 41(4), 678-692.e7. Cell Press
Hoogstrate, Y, Draaisma, K, Ghisai, S A, van Hijfte, L, Barin, N, de Heer, I, Coppieters, W, van den Bosch, T P P, Bolleboom, A, Gao, Z, Vincent, A J P E, Karim, L, Deckers, M, Taphoorn, M J B, Kerkhof, M, Weyerbrock, A, Sanson, M, Hoeben, A, Lukacova, S, Lombardi, G, Leenstra, S, Hanse, M, Fleischeuer, R E M, Watts, C, Angelopoulos, N, Gorlia, T, Golfinopoulos, V, Bours, V, van den Bent, M J, Robe, P A & French, P J 2023, ' Transcriptome analysis reveals tumor microenvironment changes in glioblastoma ', Cancer Cell, vol. 41, no. 4, pp. 678-692.e7 . https://doi.org/10.1016/j.ccell.2023.02.019

A better understanding of transcriptional evolution of IDH-wild-type glioblastoma may be crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq) (n = 322 test, n = 245 validation) on paired primary-recurrent glioblastoma resecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb4d868c4967f080400fdfa01b352cb
https://doi.org/10.1016/j.ccell.2023.02.019

Landscape of driver gene events, biomarkers, and druggable targets identified by whole-genome sequencing of glioblastomas

Autor: Harmen J.G. van de Werken, Ron H.J. Mathijssen, Kaspar Draaisma, Pierre A. Robe, Youri Hoogstrate, Sander Bins, Filip de Vos, Pim J. French, Wesley S. van de Geer

Publikováno v: Neuro-Oncology Advances, 4(1):vdab177. Oxford University Press
Neuro-oncology Advances

Background The survival of glioblastoma patients is poor. Median survival after diagnosis is 15 months, despite treatment involving surgical resection, radiotherapy, and/or temozolomide chemotherapy. Identification of novel targets and stratification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5404c926110f38006999d1815cd6bc63
https://doi.org/10.1093/noajnl/vdab177

Routine Blood Tests Do Not Predict Survival in Patients with Glioblastoma—Multivariable Analysis of 497 Patients

Autor: Pierre A. Robe, Raymond M. Schiffelers, Kaspar Draaisma, Sybren L. N. Maas, Wouter W. van Solinge, Maarten J. ten Berg, Tom J. Snijders, Sharon Berendsen, Joeky T. Senders, Marike L. D. Broekman, Tatjana Seute

Publikováno v: World Neurosurgery, 126, e1081. Elsevier Inc.

Background: Multiple reports have attributed a prognostic value to routine blood tests results for patients with glioblastoma. However, these studies have reported conflicting results and have often had small sample sizes. We sought to validate the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdeb4985066687b13fd835b80eec499
https://doi.org/10.1016/j.wneu.2019.03.053