Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kasireddy Sudarshan"'
Autor:
Ahmed M. Abdelaal, Ikjot S. Sohal, Shreyas G. Iyer, Kasireddy Sudarshan, Esteban A. Orellana, Kenan E. Ozcan, Andrea P. dos Santos, Philip S. Low, Andrea L. Kasinski
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102193- (2024)
Use of tumor-suppressive microRNAs (miRNAs) as anti-cancer agents is hindered by the lack of effective delivery vehicles, entrapment of the miRNA within endocytic compartments, and rapid degradation of miRNA by nucleases. To address these issues, we
Externí odkaz:
https://doaj.org/article/c4e68e8c068a410f86d873750e696cff
Autor:
Kelly A Rotstan, Michael M Abdelsayed, Luiz FM Passalacqua, Fabio Chizzolini, Kasireddy Sudarshan, A Richard Chamberlin, Jiří Míšek, Andrej Luptak
Publikováno v:
eLife, Vol 9 (2020)
Optogenetic tools have revolutionized the study of receptor-mediated processes, but such tools are lacking for RNA-controlled systems. In particular, light-activated regulatory RNAs are needed for spatiotemporal control of gene expression. To fill th
Externí odkaz:
https://doaj.org/article/2a5675e1dc234f54abe304366e96f809
Publikováno v:
Chemical Communications. 56:5386-5388
We report on the development of high-throughput fluorogenic assay that can streamline directed evolution of enantioselective sulfoxide reductases. As a model, methionine sulfoxide reductase A (MsrA) has been evolved to expand its limited substrate sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a507b27d36f95eddd57f7260edcfba
https://doi.org/10.1039/d0cc01660h
https://doi.org/10.1039/d0cc01660h
Autor:
Prem N. Yadav, Shalini Dogra, Indrapal Singh Aidhen, Arun kumar Boda, Ishani Bose, Kasireddy Sudarshan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:585-590
Isocoumarins are lactone ring-containing natural products, are quite abundant in microbes and higher plants, and have been shown to exhibit a broad range of pharmacological properties. However, the molecular mechanism or target of this class of molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8327948a2faebcb2108baea180313b9
https://doi.org/10.1016/j.bmcl.2018.12.057
https://doi.org/10.1016/j.bmcl.2018.12.057
Autor:
Andrej Lupták, Jiří Míšek, Fabio Chizzolini, Luiz F. M. Passalacqua, Kasireddy Sudarshan, Michael M. Abdelsayed, Kelly A Rotstan, A. Richard Chamberlin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa3a673c64b3d438daff31ea35f2880a
https://doi.org/10.7554/elife.51737.sa2
https://doi.org/10.7554/elife.51737.sa2
Publikováno v:
European Journal of Organic Chemistry. 2018:6379-6387
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b608e8a0aae8f85677045764dfcea7ed
https://doi.org/10.1002/ejoc.201801211
https://doi.org/10.1002/ejoc.201801211
Publikováno v:
European Journal of Organic Chemistry. 2017:34-38
A new route for the synthesis of 3-substituted and 8-hydroxy-3-substituted isocoumarins has been developed by using modified Julia olefination for initial C-C bond formation between aldehydes and benzylic-sulfones. Palladium-catalyzed Meinwald rearra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29900db8bd42bc8761d53716b0449c36
https://doi.org/10.1002/ejoc.201601264
https://doi.org/10.1002/ejoc.201601264
Autor:
Fabio Chizzolini, Kelly A Rotstan, Andrej Lupták, Jiří Míšek, Kasireddy Sudarshan, A. Richard Chamberlin, Luiz F. M. Passalacqua, Michael M. Abdelsayed
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Optogenetic tools have revolutionized the study of receptor-mediated biological processes, but such tools are lacking for the study of RNA-controlled systems. To fill this gap, we used in vitro selection to isolate a novel RNA that selectively binds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ad019be1a07b2dcb8388dac872e7b0
Publikováno v:
European Journal of Medicinal Chemistry. 124:428-434
The biosynthesis of leukotrienes in one of the arachidonic acid pathways and PGE2 in the other by 5-LOX and mPGES1 respectively, play pivotal roles in augmenting inflammatory responses. PGE2 is known to participate in cancer pathological processes as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94406b133974e4ab92080f3c167b3ef
https://doi.org/10.1016/j.ejmech.2016.08.066
https://doi.org/10.1016/j.ejmech.2016.08.066
Publikováno v:
European Journal of Organic Chemistry. 2015:1797-1803
A new strategy for the synthesis of 3-arylisocoumarins and 8-hydroxy-3-arylisocoumarins was investigated by using acyl anion chemistry for the initial C–C bond formation. The obtained keto esters and keto lactones as intermediates underwent based-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0251ba96d74ac54abe49a87f771e75ee
https://doi.org/10.1002/ejoc.201403524
https://doi.org/10.1002/ejoc.201403524