Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kasie, Fang"'
Autor:
Kasie, Fang, Hermes, Licea-Perez
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 223:115124
Quantitation of intracellular tri-phosphate anabolite, GSK1-TP, was required to understand drug efficacy of a proprietary molecule, GSK1; while quantitation of the di-phosphate, GSK1-DP, provided an indicator of potential GSK1-TP instability during s
Autor:
Kasie Fang, Hermes Licea-Perez
Publikováno v:
Bioanalysis. 12:467-484
Background: The continual need for the development and validation of ultra-sensitive (low pg/ml) LC–MS/MS assays in the pharmaceutical industry is largely driven by the ultra-low analyte exposure or very low sample volume. Methodology: Strategies a
Autor:
Chester L. Bowen, Hermes Licea-Perez, Christopher Matheny, Venkatraman Junnotula, Kasie Fang, Yanwen Qian
Publikováno v:
Analytical Methods. 10:3074-3080
GSK1795091 (or CRX-601), an aminoalkyl glucosaminide 4-phosphate, is a potent TLR4 agonist in clinical development for the treatment of cancer. Bioanalysis of GSK1795091 is challenging as extremely low doses (
Publikováno v:
Bioanalysis. 10(4)
Aim: GSKA is a compound that was in development in clinical trials. A bioanalysis method to quantify GSKA using volumetric absorptive microsampling (VAMS) was developed and hematocrit (HCT) related assay bias was investigated. Methodology: After accu
Autor:
Chester L. Bowen, Ciara Rodgers, Sherry Wang, Kasie Fang, Matthew Szapacs, Hermes Licea-Perez, Christopher A. Evans
Publikováno v:
Bioanalysis. 7(23)
Background: Camphanic acid chloride has proven to be an efficient chiral derivatization reagent for determination of stereoisomers. Results: The utility of chemical derivatization of various stereoisomers containing hydroxy functional groups with cam