Targeting the TDP-43 low complexity domain blocks spreading of pathology in a mouse model of ALS/FTD

Autor: Elodie Chevalier, Mickael Audrain, Monisha Ratnam, Romain Ollier, Aline Fuchs, Kasia Piorkowska, Andrea Pfeifer, Marie Kosco-Vilbois, Tamara Seredenina, Tariq Afroz

Publikováno v: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-14 (2024)

Abstract Abnormal cytoplasmic localization and accumulation of pathological transactive response DNA binding protein of 43 kDa (TDP-43) underlies several devastating diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degene

Externí odkaz: https://doaj.org/article/eb7a4f8889a94b1f9b377bfd2cada429

Development of a small D-enantiomeric Alzheimer's amyloid-β binding peptide ligand for future in vivo imaging applications.

Autor: Susanne Aileen Funke, Dirk Bartnik, Julian Marius Glück, Kasia Piorkowska, Katja Wiesehan, Urs Weber, Balazs Gulyas, Christer Halldin, Andrea Pfeifer, Christian Spenger, Andreas Muhs, Dieter Willbold

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e41457 (2012)

Alzheimer's disease (AD) is a devastating disease affecting predominantly the aging population. One of the characteristic pathological hallmarks of AD are neuritic plaques, consisting of amyloid-β peptide (Aβ). While there has been some advancement

Externí odkaz: https://doaj.org/article/ce9a1aae78d8452baa52b21d0c56408f

The development of [ 18 F]ACI‐12589, a high affinity and selective alpha‐synuclein radiotracer, as a biomarker for Parkinson’s disease and other synucleinopathies

Autor: Francesca Capotosti, Efthymia Vokali, Jerome Molette, Myriam Ravache, Christophe Delgado, Jacqueline Kocher, Laure Pittet, Ioannis K. Dimitrakopoulos, Ivan Di‐Bonaventura, Tanja Touilloux, Kasia Piorkowska, Mayank Chauhan, Heiko Kroth, Valerie Hliva, Olivier Sol, Andrea Pfeifer, Marie Kosco‐Vilbois

Publikováno v: Alzheimer's & Dementia. 17

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1127fce6d100eda3c392cbb5a85e2ff
https://doi.org/10.1002/alz.053943

O5‐06‐03: SMALL MOLECULES TARGETING TAU AGGREGATION DECREASE TAU PATHOLOGY AND NEUROINFLAMMATION IN VIVO

Autor: Emanuele Gabellieri, Sonia M. Poli, Allan Lamontanara, Andrea Pfeifer, Francesca Capotosti, Yvan Varisco, David Lowe, David T. Hickman, Kasia Piorkowska, Heiko Kroth, Sreenivasachary Nampally, Patrick Rodriguez

Publikováno v: Alzheimer's & Dementia. 15

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba744bf2f31e5cefa480e8983889c44d
https://doi.org/10.1016/j.jalz.2019.06.4866

An effector-reduced anti-ß-amyloid (Aß) antibody with unique aß binding properties promotes neuroprotection and glial engulfment of Aß

Autor: Yvan Varisco, Kasia Piorkowska, Maria Pihlgren, Oskar Adolfsson, Mark Z. Chen, Alvin Gogineni, Nicolas Toni, Carole Ho, Andreas Muhs, Andrea Pfeifer, Katia Antoniello, Michel Friesenhahn, Robby M. Weimer, Sophie Lohmann, Robert Paul, Valerie Gafner, Anna Lucia Buccarello, Janice A. Maloney, Deborah L. Mortensen, Ryan J. Watts, Jasvinder Atwal

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience
Journal of Neuroscience, vol. 32, no. 28, pp. 9677-9689

Passive immunization against β-amyloid (Aβ) has become an increasingly desirable strategy as a therapeutic treatment for Alzheimer's disease (AD). However, traditional passive immunization approaches carry the risk of Fcγ receptor-mediated overact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2cbe1eb7083c2049180d072e90c4036