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The role of bystander effects in the antitumor activity of the hypoxia-activated prodrug PR-104

Autor: Annika eFoehrenbacher, Kashyap ePatel, Maria eAbbattista, Chris P. Guise, Timothy W. Secomb, William R. Wilson, Kevin O. Hicks

Publikováno v: Frontiers in Oncology, Vol 3 (2013)

Activation of prodrugs in tumors (e.g. by bioreduction in hypoxic zones) has the potential to generate active metabolites that can diffuse within the tumor microenvironment. Such ‘bystander effects’ may offset spatial heterogeneity in prodrug act

Externí odkaz: https://doaj.org/article/9a6f98a043b24ef1966a4209ee7e682c

Identification and Preliminary Validation of Radiation Response Protein(s) in Human Blood for a High-throughput Molecular Biodosimetry Technology for the Future.

Autor: Nongrum S; Present Affiliation: Department of Biotechnology, St. Anthony's College, Shillong, Meghalaya, India., Vaiphei ST; Present Affiliation: Department of Biotechnology, Central University of Rajasthan, Bandarsindri, Kishangarh, Rajasthan, India., Keppen J; Radiation and Molecular Biology Unit, Department of Biochemistry, North-Eastern Hill University, Shillong, Meghalaya, India., Ksoo M; Radiation and Molecular Biology Unit, Department of Biochemistry, North-Eastern Hill University, Shillong, Meghalaya, India., Kashyap E; Post-graduate Intern/Trainee from St. Anthony's College, Shillong, Meghalaya, India., Sharan RN; Radiation and Molecular Biology Unit, Department of Biochemistry, North-Eastern Hill University, Shillong, Meghalaya, India.

Publikováno v: Genome integrity [Genome Integr] 2017 Jan 23; Vol. 8, pp. 5. Date of Electronic Publication: 2017 Jan 23 (Print Publication: 2017).