Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kashmira Shah"'
Autor:
Ji Zhang, Eric S. Muise, Seongah Han, Peter S. Kutchukian, Philippe Costet, Yonghua Zhu, Yanqing Kan, Haihong Zhou, Vinit Shah, Yongcheng Huang, Ashmita Saigal, Taro E. Akiyama, Xiao-Lan Shen, Tian-Quan Cai, Kashmira Shah, Ester Carballo-Jane, Emanuel Zycband, Lan Yi, Ye Tian, Ying Chen, Jason Imbriglio, Elizabeth Smith, Kristine Devito, James Conway, Li-Jun Ma, Maarten Hoek, Iyassu K. Sebhat, Andrea M. Peier, Saswata Talukdar, David G. McLaren, Stephen F. Previs, Kristian K. Jensen, Shirly Pinto
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 4, Pp 100056- (2020)
Summary: Fibrosis, or the accumulation of extracellular matrix, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, we cross-examine human primary cells from various tissues treated with TGF-β, a
Externí odkaz:
https://doaj.org/article/063a70c64d8f4793abcfad76e4a93d9a
Autor:
David G. McLaren, Lan Yi, Shirly Pinto, Ye Tian, Kristian K. Jensen, Kristine Devito, Elizabeth Smith, Philippe Costet, Iyassu K. Sebhat, Stephen F. Previs, Emanuel Zycband, James Conway, Eric S. Muise, Seongah Han, Yongcheng Huang, Kashmira Shah, Ying Chen, Jason E. Imbriglio, Ji Zhang, Vinit Shah, Peter S. Kutchukian, Haihong Zhou, Tian-Quan Cai, Li-Jun Ma, Yonghua Zhu, Yanqing Kan, Taro E. Akiyama, Ester Carballo-Jane, Maarten Hoek, Xiaolan Shen, Saswata Talukdar, Andrea M. Peier, Ashmita Saigal
Publikováno v:
Cell Reports Medicine
Cell Reports Medicine, Vol 1, Iss 4, Pp 100056-(2020)
Cell Reports Medicine, Vol 1, Iss 4, Pp 100056-(2020)
Summary Fibrosis, or the accumulation of extracellular matrix, is a common feature of many chronic diseases. To interrogate core molecular pathways underlying fibrosis, we cross-examine human primary cells from various tissues treated with TGF-β, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfdffc0cd9c8343fd1d503ee93abf772
http://europepmc.org/articles/PMC7659620
http://europepmc.org/articles/PMC7659620
Autor:
Eric S. Muise, Yanqing Kan, Stephen F. Previs, Li-Jun Ma, James Conway, Haihong Zhou, Vinit Shah, Yonghua Zhu, Peter S. Kutchukian, Yongcheng Huang, David G. McLaren, Ji Zhang, Shirly Pinto, Emanuel Zycband, Kristine Devito, Ying Chen, Jason E. Imbriglio, Maarten Hoek, Philippe Costet, Taro E. Akiyama, Elizabeth Smith, Tian-Quan Cai, Lan Yi, Ye Tian, Andrea M. Peier, Xiaolan Shen, Kashmira Shah
Publikováno v:
SSRN Electronic Journal.
Fibrosis, or the accumulation of extracellular matrix, causes loss of organ function and is a common feature of many chronic diseases. To interrogate the core molecular pathways of fibrosis, we cross-examined human primary cells from various tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a862d77b124f269e5f18774971616ae
https://doi.org/10.2139/ssrn.3209457
https://doi.org/10.2139/ssrn.3209457
Autor:
Lee-Yuh Pai, Yuping Zhu, Richard Visconti, Xiaoyan Zhou, John P. Felix, Melba Hernandez, Jing Chen, Michael Margulis, Nardos Teumelsan, Sophie Roy, Kathleen A. Sullivan, Jessica Liu, Joseph M. Metzger, Aaron Corona, Gregory J. Kaczorowski, Maria L. Garcia, Lihu Yang, Shawn P. Walsh, Birgit T. Priest, Alexander Pasternak, Caryn Hampton, Emma R. Parmee, Vincent Tong, Brande Thomas-Fowlkes, Haifeng Tang, Magdalena Alonso-Galicia, Kashmira Shah, Michael J. Forrest, Richard M. Brochu, Ross Bentley, Sookhee Ha, Karen Owens, Aurash Shahripour, Andrew M. Swensen, Jessica Frie, Adam B. Weinglass, Timothy Bailey
Publikováno v:
ACS Medicinal Chemistry Letters. 6:747-752
A new subseries of ROMK inhibitors exemplified by 28 has been developed from the initial screening hit 1. The excellent selectivity for ROMK inhibition over related ion channels and pharmacokinetic properties across preclinical species support furthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454c1f32ec6c3f7a915fe446fd2867a1
https://doi.org/10.1021/ml500440u
https://doi.org/10.1021/ml500440u
Autor:
O. Reardon, Christopher Sampson, John A. Schneider, Brendan Mulhern, R. Addo, Bert Janssen, Michael Herdman, Kashmira Shah, Kevin R. Page, M. Rodes Sanchez, P. Haywood, C. Thetford
Publikováno v:
Value in Health. 22:S733
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f05fe3fa1e94093b25c99c3ec66b53a3
https://doi.org/10.1016/j.jval.2019.09.1759
https://doi.org/10.1016/j.jval.2019.09.1759
Autor:
Gloria C. Koo, Martin S. Springer, Lorraine Malkowitz, Douglas W. Kawka, Kang Cheng, Qi Luo, Serguei Stepaniants, Kenneth K. Wu, Irwin I. Singer, Jeffrey Yuan, Andrew S. Plump, Cheryl B. Le Grand, Jun Zhu, Milana Maletic, Samuel D. Wright, James M. Balkovec, Gloria J.-F. Ding, Sherman T. Waddell, Xia Yang, Rolf Thieringer, Kashmira Shah, Pek Yee Lum, Mingjuan Jane Luo, I-Ming Wang, Anne Hermanowski-Vosatka
Publikováno v:
Physiological Genomics. 45:47-57
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is implicated in the etiology of metabolic syndrome. We previously showed that pharmacological inhibition of 11β-HSD1 ameliorated multiple facets of metabolic syndrome and attenuated atheroscleros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62219a7783ded2299858a49a0cadc560
https://doi.org/10.1152/physiolgenomics.00109.2012
https://doi.org/10.1152/physiolgenomics.00109.2012
Autor:
Haifeng Tang, Kashmira Shah, Maria L. Garcia, Alexander Pasternak, Magdalena Alonso-Galicia, Brande Thomas-Fowlkes, Cordelia Rasa, Joseph M. Metzger, Sophie Roy, Lee-Yuh Pai, Jessica Liu, Olga Price, Vince Tong, Birgit T. Priest, Gregory J. Kaczorowski, James D. Ormes, Charles Gill, Aaron Corona, John P. Felix, Jianying Xiao, Kathleen A. Sullivan, Karen Owens, Caryn Hampton, Xiaoyan Zhou, Martin Köhler
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 359(1)
The renal outer medullary potassium (ROMK) channel, located at the apical surface of epithelial cells in the thick ascending loop of Henle and cortical collecting duct, contributes to salt reabsorption and potassium secretion, and represents a target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a55d5d0f3672edd7db9d025d76d0fd
https://pubmed.ncbi.nlm.nih.gov/27432892
https://pubmed.ncbi.nlm.nih.gov/27432892
Autor:
Divya Kharbanda, Gina M. Santorelli, Jianying Xiao, Hratch J. Zokian, Mitree M. Ponpipom, Steven S. Mundt, Anne Hermanowski-Vosatka, Susan D. Aster, Donald W. Graham, Samuel D. Wright, James M. Balkovec, Gool F. Patel, Kashmira Shah, Rolf Thieringer, Marty S. Springer, Michael J. Szymonifka
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2799-2804
Adamantyl triazoles were identified as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). They are active both in in vitro and in in vivo pharmacodynamic models. The synthesis and structure–activity relationships of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40c1a0b59a6be6d9abd5ff2d5f9ef6b
https://doi.org/10.1016/j.bmcl.2008.04.010
https://doi.org/10.1016/j.bmcl.2008.04.010
Autor:
Kang Cheng, Matthias Strowski, Jianying Xiao, Tsuei-Ju Wu, Ning Ren, Nancy Robertson, Martin S. Springer, Kenneth K. Wu, Zhihua Li, James M. Balkovec, Melba Hernandez, Howard Y. Chen, Cheryl B. Le Grand, Bill Pikounis, Anne Hermanowski-Vosatka, Joseph M. Metzger, Samuel D. Wright, Steven H. Olson, Alison M. Strack, Gloria C. Koo, Steven S. Mundt, Rolf Thieringer, Heather Noonan, Kashmira Shah, James M. Schaeffer, Christian N. Nunes, Bei B. Zhang
Publikováno v:
The Journal of Experimental Medicine
The enzyme 11β–hydroxysteroid dehydrogenase (HSD) type 1 converts inactive cortisone into active cortisol in cells, thereby raising the effective glucocorticoid (GC) tone above serum levels. We report that pharmacologic inhibition of 11β-HSD1 has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2100c617c4f08e8bc6b622a8ee436ebe
http://europepmc.org/articles/PMC2212859
http://europepmc.org/articles/PMC2212859
Autor:
Gloria C. Koo, Laurie A. Castonguay, Mary Jo Staruch, Randal M. Bugianesi, John P. Felix, George A. Doss, Robert S. Slaughter, Marty S. Springer, Andrew Kotliar, Sookhee Ha, Kathleen M. Rupprecht, William H. Parsons, Gregory J. Kaczorowski, Kashmira Shah, Shouwu Miao, Jianming Bao, Maria L. Garcia, Frank Kayser, Robert K. Baker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:447-451
Kv1.3, the voltage-gated potassium channel in human T cells, represents a new target for treating immunosuppression and autoimmune diseases. Correolide (1), a pentacyclic natural product, is a potent and selective Kv1.3 channel blocker. Simplificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b217212f1114b7e5c9d40397d6232c7
https://doi.org/10.1016/j.bmcl.2004.10.058
https://doi.org/10.1016/j.bmcl.2004.10.058