Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Kashish Manchanda"'
Autor:
Matti Adam, Kashish Manchanda, Jan Víteček, Anna Klinke, Stephan Baldus, Martin Mollenhauer, Volker Rudolph, Lukáš Kubala, Christina Kerkenpaß, Hana Kolarova
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38:1859-1867
Objective— The leukocyte heme-enzyme MPO (myeloperoxidase) exerts proinflammatory effects on the vascular system primarily linked to its catalytic properties. Recent studies have shown that MPO, depending on its cationic charge, mediates neutrophil
Autor:
Stanley L. Hazen, Gustavo A. Heresi, Simon Molz, Matthias Berlin, Eva Berghausen, Hans Klose, Tanja K. Rudolph, Martin Mollenhauer, Denise Lau, Stephan Baldus, Dennis Mehrkens, Lisa Remane, Metin Aytekin, Thorben Ravekes, Jan K. Hennigs, Raed A. Dweik, Kai Friedrichs, Ralph T. Schermuly, Charlotte Kaltwasser, Matti Adam, Stephan Rosenkranz, Erik Michaëlsson, Volker Rudolph, Lukáš Kubala, Kashish Manchanda, Anna Klinke
Publikováno v:
JCI Insight. 3
Pulmonary arterial hypertension (PAH) remains a disease with limited therapeutic options and dismal prognosis. Despite its etiologic heterogeneity, the underlying unifying pathophysiology is characterized by increased vascular tone and adverse remode
Autor:
Florian Deuschl, Max Lange, Matti Adam, Stanley L. Hazen, Yuping Wu, Martina Maass, Johanna Schneider, W.H. Wilson Tang, Tomo Saric, Jan Gesenberg, Jenny Krause, Lukáš Kubala, Volker Rudolph, Tanja K. Rudolph, Stephan Baldus, Marcel Halbach, Thorben Ravekes, Christina Kerkenpaß, Lisa Remane, Kashish Manchanda, Dennis Mehrkens, Kai Friedrichs, Birgit Geertz, Anna Klinke, Thomas Eschenhagen, Gabriel Peinkofer, Martin Mollenhauer, Denise Lau
Publikováno v:
Circulation research. 121(1)
Rationale: Ventricular arrhythmias remain the leading cause of death in patients suffering myocardial ischemia. Myeloperoxidase, a heme enzyme released by polymorphonuclear neutrophils, accumulates within ischemic myocardium and has been linked to ad