Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Kashish Chetal"'
Autor:
Emely L. Verweyen, Kairavee Thakkar, Sanjeev Dhakal, Elizabeth Baker, Kashish Chetal, Daniel Schnell, Scott Canna, Alexei A. Grom, Nathan Salomonis, Grant S. Schulert
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 22 (2023)
Systemic autoimmune and autoinflammatory diseases are characterized by genetic and cellular heterogeneity. While current single-cell genomics methods provide insights into known disease subtypes, these analysis methods do not readily reveal novel cel
Externí odkaz:
https://doaj.org/article/d5179c6c7e644a40aec238db94ea243c
Autor:
Chih-Chung Jerry Lin, Fanny Herisson, Hoang Le, Nader Jaafar, Kashish Chetal, Mary K. Oram, Kelly L. Flynn, Evan P. Gavrilles, Ruslan I. Sadreyev, Felipe L. Schiffino, Rudolph E. Tanzi
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113141- (2023)
Summary: Emerging evidence suggests that peripheral immune cells contribute to Alzheimer’s disease (AD) neuropathogenesis. Among these, mast cells are known for their functions in allergic reactions and neuroinflammation; however, little is known a
Externí odkaz:
https://doaj.org/article/ebc21dd290af4b188e93315e9f2e49f6
Autor:
Aidan M. Fenix, Yuichiro Miyaoka, Alessandro Bertero, Steven M. Blue, Matthew J. Spindler, Kenneth K. B. Tan, Juan A. Perez-Bermejo, Amanda H. Chan, Steven J. Mayerl, Trieu D. Nguyen, Caitlin R. Russell, Paweena P. Lizarraga, Annie Truong, Po-Lin So, Aishwarya Kulkarni, Kashish Chetal, Shashank Sathe, Nathan J. Sniadecki, Gene W. Yeo, Charles E. Murry, Bruce R. Conklin, Nathan Salomonis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mutations in the splicing factor RBM20 cause aggressive Dilated Cardiomyopathy. Here the authors generated RBM20 R636S mutants and knockout in human iPSC-derived cardiomyocytes. Mutant RBM20 showed different target RNA binding, altered splicing and l
Externí odkaz:
https://doaj.org/article/f87c8729e80949bda7d8b7b816b64084
Autor:
Augusto F. Schmidt, Daniel J. Schnell, Kenneth P. Eaton, Kashish Chetal, Paranthaman S. Kannan, Lisa A. Miller, Claire A. Chougnet, Daniel T. Swarr, Alan H. Jobe, Nathan Salomonis, Beena D. Kamath-Rayne
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
Accurate estimate of fetal maturity could provide individualized guidance for delivery of complicated pregnancies. However, current methods are invasive, have low accuracy, and are limited to fetal lung maturation. To identify diagnostic gestational
Externí odkaz:
https://doaj.org/article/65f498c27850421f9199b07071f4e9d3
Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
Autor:
Michael J. Petrany, Casey O. Swoboda, Chengyi Sun, Kashish Chetal, Xiaoting Chen, Matthew T. Weirauch, Nathan Salomonis, Douglas P. Millay
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mammalian skeletal muscle is composed of multinucleated myofibers, containing hundreds of nuclei that coordinate cellular function. Here, the authors show that single-nucleus RNA-sequencing reveals rare and emergent myonuclear populations, and uncove
Externí odkaz:
https://doaj.org/article/b1bd009b492847ec94ecd25cf3c44bce
Autor:
Svetlana S. Itskovich, Arun Gurunathan, Jason Clark, Matthew Burwinkel, Mark Wunderlich, Mikaela R. Berger, Aishwarya Kulkarni, Kashish Chetal, Meenakshi Venkatasubramanian, Nathan Salomonis, Ashish R. Kumar, Lynn H. Lee
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The alternative splicing regulator MBNL1 is overexpressed in MLL-rearranged leukaemia. Here, the authors show that MBNL1-mediated alternative splicing leads to a specific splicing profile in MLL-rearranged leukaemia and loss or inhibition of MBNL1 im
Externí odkaz:
https://doaj.org/article/1b153388c9a248a7aa9ef84624fc49dd
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100085- (2020)
Summary: Retention of multiplet captures in single-cell RNA sequencing (scRNA-seq) data can hinder identification of discrete or transitional cell populations and associated marker genes. To overcome this challenge, we created DoubletDecon to identif
Externí odkaz:
https://doaj.org/article/2fc0667146e44541a9085e87dc3f4da9
Autor:
Jared M. Churko, Priyanka Garg, Barbara Treutlein, Meenakshi Venkatasubramanian, Haodi Wu, Jaecheol Lee, Quinton N. Wessells, Shih-Yu Chen, Wen-Yi Chen, Kashish Chetal, Gary Mantalas, Norma Neff, Eric Jabart, Arun Sharma, Garry P. Nolan, Nathan Salomonis, Joseph C. Wu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Human induced pluripotent stem cell derived cardiomyocytes are a powerful model for cardiogenesis and disease in vitro. Here the authors comprehensively map cardiac differentiation using multiple modalities, including single-cell RNA seq and CyTOF, i
Externí odkaz:
https://doaj.org/article/2ddb8b7790bb4652b885d858f26957c7
Autor:
Vishnu Modur, Navneet Singh, Vakul Mohanty, Eunah Chung, Belal Muhammad, Kwangmin Choi, Xiaoting Chen, Kashish Chetal, Nancy Ratner, Nathan Salomonis, Matthew T. Weirauch, Susan Waltz, Gang Huang, Lisa Privette-Vinnedge, Joo-Seop Park, Edith M. Janssen, Kakajan Komurov
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Transcription elongation (TE) is a key point of inducible gene expression regulation. Here, the authors report widespread TE defects (TEdeff) in a high proportion of cancers that correlate with poor immunotherapy response, highlighting TE defects as
Externí odkaz:
https://doaj.org/article/942ee42acc244ca2beabb5d1cf1d3a26
Autor:
Jing Fang, Tomoya Muto, Maria Kleppe, Lyndsey C. Bolanos, Kathleen M. Hueneman, Callum S. Walker, Leesa Sampson, Ashley M. Wellendorf, Kashish Chetal, Kwangmin Choi, Nathan Salomonis, Yongwon Choi, Yi Zheng, Jose A. Cancelas, Ross L. Levine, Daniel T. Starczynowski
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1250-1262 (2018)
Summary: Basal nuclear factor κB (NF-κB) activation is required for hematopoietic stem cell (HSC) homeostasis in the absence of inflammation; however, the upstream mediators of basal NF-κB signaling are less well understood. Here, we describe TRAF
Externí odkaz:
https://doaj.org/article/4daedec41a394d7e95b5498a1278e32b