Výsledky vyhledávání - "Kashif M, Khan"

Regarding a Persisting Puzzle in Olefin Metathesis with Ru Complexes: Why are Transformations of Alkenes with a Small Substituent Z-Selective?

Autor: Ming Joo Koh, R. Kashif M. Khan, Amir H. Hoveyda, Sebastian Torker

Publikováno v: Organometallics. 35:543-562

An enduring question in olefin metathesis is that reactions carried out with widely accessible Ru dichloro complexes, which typically favor E alkenes, generate Z isomers preferentially when substrates bearing a smaller substituent are used; Z enol et

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47e859a5e9ae56aed03419393d009ace
https://doi.org/10.1021/acs.organomet.5b00970

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Catalytic Arylhydroxylation of Dehydroalanine in Continuous Flow for Simple Access to Unnatural Amino Acids

Autor: Yang Zhao, Stephen L. Buchwald, Tal D. Scully, R. Kashif M. Khan

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 24(57)

This report discloses the first example of catalytic arylhydroxylation of dehydroalanine with aryldiazonium salts. Aryldiazonium salts, which are generated from aniline precursors under partially aqueous conditions in continuous flow, efficiently rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca0b88d5ed849f94089199bff46c0aa
https://pubmed.ncbi.nlm.nih.gov/30102444

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High-value alcohols and higher-oxidation-state compounds by catalytic Z-selective cross-metathesis

Autor: Malte S. Mikus, Miao Yu, Ming Joo Koh, R. Kashif M. Khan, Amir H. Hoveyda, Sebastian Torker

Publikováno v: Nature. 517:181-186

A ruthenium–disulfide catalyst is presented that is effective in generating compounds of medical and industrial utility (alcohols that contain a phenol, an aldehyde, or a carboxylic acid) by room-temperature, inexpensive, high-yielding cross-metath

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e71af4f1e6fd262b6b276dde57e6ce9
https://doi.org/10.1038/nature14061

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Cytotoxicity of the Roots of Trillium govanianum Against Breast (MCF7), Liver (HepG2), Lung (A549) and Urinary Bladder (EJ138) Carcinoma Cells

Autor: Kashif M, Khan, Lutfun, Nahar, Afaf, Al-Groshi, Alexandra G, Zavoianu, Andrew, Evans, Nicola M, Dempster, Jean D, Wansi, Fyaz M D, Ismail, Abdul, Mannan, Satyajit D, Sarker

Publikováno v: Phytotherapy research : PTR. 30(10)

Trillium govanianum Wall. (Melanthiaceae alt. Trilliaceae), commonly known as 'nag chhatri' or 'teen patra', is a native species of the Himalayas. It is used in various traditional medicines containing both steroids and sex hormones. In folk medicine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::70c27abdbb2cc93e5abec834f3b88f02
https://pubmed.ncbi.nlm.nih.gov/27364153

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Z- and Enantioselective Ring-Opening/Cross-Metathesis with Enol Ethers Catalyzed by Stereogenic-at-Ru Carbenes: Reactivity, Selectivity, and Curtin–Hammett Kinetics

Autor: Sebastian Torker, R. Kashif M. Khan, Robert V. O’Brien, Amir H. Hoveyda, Bo Li

Publikováno v: Journal of the American Chemical Society. 134:12774-12779

The first instances of Z- and enantioselective Ru-catalyzed olefin metathesis are presented. Ring-opening/cross-metathesis (ROCM) reactions of oxabicyclic alkenes and enol ethers and a phenyl vinyl sulfide are promoted by 0.5–5.0 mol % of enantiome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0548f5be78124a30309b91743fab3c
https://doi.org/10.1021/ja304827a

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Synthesis, Isolation, Characterization, and Reactivity of High-Energy Stereogenic-at-Ru Carbenes: Stereochemical Inversion through Olefin Metathesis and Other Pathways

Autor: Sebastian Torker, Pamela J. Lombardi, Adil R. Zhugralin, R. Kashif M. Khan, Robert V. O’Brien, Amir H. Hoveyda

Publikováno v: Journal of the American Chemical Society. 134:12438-12441

The synthesis, isolation, purification (routine silica gel chromatography), and spectroscopic characterization of high-energy endo stereogenic-at-Ru complex isomers, generated by ring-opening/cross-metathesis (ROCM) reaction of the corresponding exo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9fc9af4e3dc9d25dd85744416db447
https://doi.org/10.1021/ja3056722

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Reactivity and selectivity differences between catecholate and catechothiolate Ru complexes. Implications regarding design of stereoselective olefin metathesis catalysts

Autor: R. Kashif M. Khan, Amir H. Hoveyda, Sebastian Torker

Publikováno v: Journal of the American Chemical Society. 136(41)

The origins of the unexpected finding that Ru catechothiolate complexes, in contrast to catecholate derivatives, promote exceptional Z-selective olefin metathesis reactions are elucidated. We show that species containing a catechothiolate ligand, unl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0e4052ba4c196488274667304bc640
https://pubmed.ncbi.nlm.nih.gov/25268949

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ChemInform Abstract: Broadly Applicable Z- and Diastereoselective Ring-Opening/Cross-Metathesis Catalyzed by a Dithiolate Ru Complex

Autor: Sebastian Torker, Amir H. Hoveyda, Ming Joo Koh, R. Kashif M. Khan

Publikováno v: ChemInform. 45

A broadly applicable Ru-catalyzed protocol for Z-selective ring-opening/cross-metathesis (ROCM) is disclosed. In addition to reactions relating to terminal alkenes of different sizes, the first examples of Z-selective ROCM processes involving heteroa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ac1c4447220f43b842b60c7ede416c4
https://doi.org/10.1002/chin.201432067

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