Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kasey R. Hutt"'
Autor:
Katannya Kapeli, Gabriel A. Pratt, Anthony Q. Vu, Kasey R. Hutt, Fernando J. Martinez, Balaji Sundararaman, Ranjan Batra, Peter Freese, Nicole J. Lambert, Stephanie C. Huelga, Seung J. Chun, Tiffany Y. Liang, Jeremy Chang, John P. Donohue, Lily Shiue, Jiayu Zhang, Haining Zhu, Franca Cambi, Edward Kasarskis, Shawn Hoon, Manuel Ares Jr., Christopher B. Burge, John Ravits, Frank Rigo, Gene W. Yeo
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Abnormal functions of RNA-binding proteins TAF15, FUS and TDP43 are associated with amyotrophic lateral sclerosis. Here, Kapeli et al. characterize the RNA targets of TAF15 and identify points of convergence and divergence between the targets of TAF1
Externí odkaz:
https://doaj.org/article/d8f4356db05e4c6e9ae5ac8588f8d310
Autor:
Daniel A. Lorenz, Hsuan-Lin Her, Kylie A. Shen, Katie Rothamel, Kasey R. Hutt, Allan C. Nojadera, Stephanie C. Bruns, Sergei A. Manakov, Brian A. Yee, Karen B. Chapman, Gene W. Yeo
Publikováno v:
Nature Methods. 20:65-69
Ultraviolet crosslinking and immunoprecipitation (CLIP) methodologies enable the identification of RNA binding sites of RNA-binding proteins (RBPs). Despite improvements in the library preparation of RNA fragments, the enhanced CLIP (eCLIP) protocol
Autor:
Christopher Benner, Sergiy Konovalov, Carlos Mackintosh, Kasey R Hutt, Rieka Stunnenberg, Ivan Garcia-Bassets
Publikováno v:
PLoS Genetics, Vol 9, Iss 11, p e1003906 (2013)
Genome-wide maps of DNase I hypersensitive sites (DHSs) reveal that most human promoters contain perpetually active cis-regulatory elements between -150 bp and +50 bp (-150/+50 bp) relative to the transcription start site (TSS). Transcription factors
Externí odkaz:
https://doaj.org/article/411a363af1d0450db1c55ef09c6f6edd
Autor:
Ryan T. Libby, Stuart J Rabin, Ruth Wang, Elaine Pirie, Ranjan Batra, Florian Krach, Anthony Q. Vu, Zacharias Kohl, John Ravits, Gene W. Yeo, Emily C. Wheeler, Michael Baughn, Kasey R. Hutt, María Jesús Delgado Rodríguez, Sandra Diaz-Garcia, Jennifer E. Stauffer, Shahram Saberi, Beate Winner, Assael A. Madrigal
Publikováno v:
Acta neuropathologica, vol 136, iss 3
Sporadic amyotrophic lateral sclerosis (sALS) is the most common form of ALS, however, the molecular mechanisms underlying cellular damage and motor neuron degeneration remain elusive. To identify molecular signatures of sALS we performed genome-wide
Autor:
Kasey R. Hutt, Shawn Hoon, Jiayu Zhang, Gene W. Yeo, Manuel Ares, Edward J. Kasarskis, Anthony Q. Vu, Jeremy B. Chang, Peter Freese, Balaji Sundararaman, Ranjan Batra, Tiffany Y. Liang, Gabriel A. Pratt, John Paul Donohue, Lily Shiue, Haining Zhu, Nicole J. Lambert, Christopher B. Burge, Stephanie C. Huelga, Fernando J. Martinez, John Ravits, Franca Cambi, Frank Rigo, Katannya Kapeli, Seung J. Chun
Publikováno v:
Nature communications, vol 7, iss 1
Nature
Nature Communications
Kapeli, K; Pratt, GA; Vu, AQ; Hutt, KR; Martinez, FJ; Sundararaman, B; et al.(2016). Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses. NATURE COMMUNICATIONS, 7, 12143. doi: 10.1038/ncomms12143. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/7qq661nt
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature
Nature Communications
Kapeli, K; Pratt, GA; Vu, AQ; Hutt, KR; Martinez, FJ; Sundararaman, B; et al.(2016). Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses. NATURE COMMUNICATIONS, 7, 12143. doi: 10.1038/ncomms12143. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/7qq661nt
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The RNA-binding protein (RBP) TAF15 is implicated in amyotrophic lateral sclerosis (ALS). To compare TAF15 function to that of two ALS-associated RBPs, FUS and TDP-43, we integrate CLIP-seq and RNA Bind-N-Seq technologies, and show that TAF15 binds t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86545d7be75e337d578d14a302e22553
https://escholarship.org/uc/item/7qq661nt
https://escholarship.org/uc/item/7qq661nt
Autor:
Hilal Kazan, Anthony Q. Vu, Tiffany Y. Liang, Bernice Y. Yan, Gene W. Yeo, Quaid Morris, Jason L. Nathanson, Kasey R. Hutt, Shawn Hoon, Thomas J. Stark, Michael T. Lovci, Katannya Kapeli, Katlin B. Massirer, Stephanie C. Huelga, Melissa L. Wilbert, Stella X. Chen
Publikováno v:
Molecular Cell. 48(2):195-206
LIN28 is a conserved RNA-binding protein implicated in pluripotency, reprogramming, and oncogenesis. It was previously shown to act primarily by blocking let-7 microRNA (miRNA) biogenesis, but here we elucidate distinct roles of LIN28 regulation via
Autor:
Gene W. Yeo, Magdalini Polymenidou, Kasey R. Hutt, C. Frank Bennett, Clotilde Lagier-Tourenne, Don W. Cleveland
Publikováno v:
Brain Research. 1462:3-15
Amyotrophic lateral sclerosis (ALS) research is undergoing an era of unprecedented discoveries with the identification of new genes as major genetic causes of this disease. These discoveries reinforce the genetic, clinical and pathological overlap be
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
Autor:
Stephanie C. Huelga, Jacqueline T. Moran, Gene W. Yeo, Holly B. Kordasiewicz, Yalda Sedaghat, Shuo-Chien Ling, Magdalini Polymenidou, Lily Shiue, Tiffany Y. Liang, Curt Mazur, Don W. Cleveland, Edward Wancewicz, Clotilde Lagier-Tourenne, Kasey R. Hutt, John Paul Donohue, C. Frank Bennett, Eveline Sun
Publikováno v:
Nature neuroscience
Cross-linking and immunoprecipitation coupled with high-throughput sequencing was used to identify binding sites within 6,304 genes as the brain RNA targets for TDP-43, an RNA binding protein which when mutated causes Amyotrophic Lateral Sclerosis (A
Autor:
Ivan Garcia-Bassets, Qidong Hu, Kasey R. Hutt, Esperanza Nunez, Maria Dafne Cardamone, Xiang-Dong Fu, Christopher K. Glass, Michael G. Rosenfeld, Young-Soo Kwon, Kenneth A. Ohgi, David W. Rose
Publikováno v:
Cell. 132:996-1010
While the transcriptional machinery has been extensively dissected at the molecular level, little is known about regulation of chromosomal organization in the three-dimensional space of the nucleus to achieve integrated transcriptional responses to d
Autor:
Michael G. Rosenfeld, Thorsten Cramer, Kasey R. Hutt, Xiaoyan Zhu, Esperanza Nunez, Victoria V. Lunyak, Lluis Montoliu, Ángel García-Díaz, Yun C. Yung, Bong-Gun Ju, Christopher K. Glass, Kenneth A. Ohgi, R. Roy, Gratien G. Prefontaine
Publikováno v:
Science. 317:248-251
The temporal and spatial regulation of gene expression in mammalian development is linked to the establishment of functional chromatin domains. Here, we report that tissue-specific transcription of a retrotransposon repeat in the murine growth hormon