Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Kasey R. Cargill"'
Autor:
Kasey R. Cargill, C. Allison Stewart, Elizabeth M. Park, Kavya Ramkumar, Carl M. Gay, Robert J. Cardnell, Qi Wang, Lixia Diao, Li Shen, You-Hong Fan, Wai Kin Chan, Philip L. Lorenzi, Trudy G. Oliver, Jing Wang, Lauren A. Byers
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-16 (2021)
Abstract Introduction The transcription factor MYC is overexpressed in 30% of small cell lung cancer (SCLC) tumors and is known to modulate the balance between two major pathways of metabolism: glycolysis and mitochondrial respiration. This duality o
Externí odkaz:
https://doaj.org/article/0736ef15a3794632870c3c21f1f36c7a
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Metabolic reprogramming is a hallmark of cancer initiation, progression, and relapse. From the initial observation that cancer cells preferentially ferment glucose to lactate, termed the Warburg effect, to emerging evidence indicating that metabolic
Externí odkaz:
https://doaj.org/article/066a655bf2544ba0af0638ec6cc07cca
Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4+ T Cells in Type 1 Diabetes
Autor:
Christina P. Martins, Lee A. New, Erin C. O’Connor, Dana M. Previte, Kasey R. Cargill, Isabelle L. Tse, Sunder Sims- Lucas, Jon D. Piganelli
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In Type 1 Diabetes (T1D), CD4+ T cells initiate autoimmune attack of pancreatic islet β cells. Importantly, bioenergetic programs dictate T cell function, with specific pathways required for progression through the T cell lifecycle. During activatio
Externí odkaz:
https://doaj.org/article/d2aeee18bae74b039de8bfa66700b055
Autor:
Lauren A. Byers, Don L. Gibbons, Carl M. Gay, Jing Wang, John V. Heymach, You-Hong Fan, B. Leticia Rodriguez, David H. Peng, Robert J. Cardnell, Lixia Diao, Li Shen, Qi Wang, Carminia M. Della Corte, Kasey R. Cargill, C. Allison Stewart, Kavya Ramkumar
Supplementary Fig. S1: A subset of treatment-naïve NSCLC and LCNEC tumors expresses high AXL levels and EMT scores.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe9f157d85fceb2f4ef47eeaaedab13
https://doi.org/10.1158/1541-7786.22526645.v1
https://doi.org/10.1158/1541-7786.22526645.v1
Autor:
Lauren A. Byers, Don L. Gibbons, Carl M. Gay, Jing Wang, John V. Heymach, You-Hong Fan, B. Leticia Rodriguez, David H. Peng, Robert J. Cardnell, Lixia Diao, Li Shen, Qi Wang, Carminia M. Della Corte, Kasey R. Cargill, C. Allison Stewart, Kavya Ramkumar
Table S1. Mutations in key oncogenes in lung cancer cell lines tested.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27e9746a2cbf84f138754f24166ae49
https://doi.org/10.1158/1541-7786.22526621
https://doi.org/10.1158/1541-7786.22526621
Autor:
Lauren A. Byers, Don L. Gibbons, Carl M. Gay, Jing Wang, John V. Heymach, You-Hong Fan, B. Leticia Rodriguez, David H. Peng, Robert J. Cardnell, Lixia Diao, Li Shen, Qi Wang, Carminia M. Della Corte, Kasey R. Cargill, C. Allison Stewart, Kavya Ramkumar
AXL, a TAM (TYRO3, AXL, and MERTK) family receptor tyrosine kinase, is increasingly being recognized as a key determinant of resistance to targeted therapies, as well as chemotherapy and radiation in non–small cell lung cancer (NSCLC) and other can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9c21d897465f7a08444ce7a8c783bcf
https://doi.org/10.1158/1541-7786.c.6545156.v1
https://doi.org/10.1158/1541-7786.c.6545156.v1
Autor:
Kiran Kundu, Robert J. Cardnell, Bingnan Zhang, Li Shen, C. Allison Stewart, Kavya Ramkumar, Kasey R. Cargill, Jing Wang, Carl M. Gay, Lauren A. Byers
Publikováno v:
Transl Lung Cancer Res
BACKGROUND: Lurbinectedin recently received FDA accelerated approval as a second line treatment option for metastatic small cell lung cancer (SCLC). However, there are currently no established biomarkers to predict SCLC sensitivity or resistance to l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed87e0335f9769b982f0b4cedeb3d2f
https://doi.org/10.21037/tlcr-21-437
https://doi.org/10.21037/tlcr-21-437
Autor:
Kasey R. Cargill, Sanja Dacic, Riyue Bao, Bharathri Sivakama, Eric S. Goetzman, Steven J. Mullett, Stacy G. Wendell, Sameer Agnihotri, Laura P. Stabile, Timothy F. Burns
Publikováno v:
Cancer Research. 83:6042-6042
Non-small cell lung cancer (NSCLC) has the highest incidence of brain metastases (BM) with almost 40% of lung cancer patients developing BM throughout the course of their disease. The presence of BM portends an extremely poor prognosis even when extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62a7857c83cba49db902fe34227d605a
https://doi.org/10.1158/1538-7445.am2023-6042
https://doi.org/10.1158/1538-7445.am2023-6042
Autor:
C. Allison Stewart, Carl M. Gay, Kavya Ramkumar, Kasey R. Cargill, Robert J. Cardnell, Monique B. Nilsson, Simon Heeke, Elizabeth M. Park, Samrat T. Kundu, Lixia Diao, Qi Wang, Li Shen, Yuanxin Xi, Bingnan Zhang, Carminia Maria Della Corte, Youhong Fan, Kiran Kundu, Boning Gao, Kimberley Avila, Curtis R. Pickering, Faye M. Johnson, Jianjun Zhang, Humam Kadara, John D. Minna, Don L. Gibbons, Jing Wang, John V. Heymach, Lauren Averett Byers
Publikováno v:
Journal of Thoracic Oncology
Background: SARS-CoV-2 infection is the cause of the respiratory illness COVID-19, which presents most frequently with respiratory symptoms SARS-CoV-2 cell entry requires interactions with ACE2 and TMPRSS2 on the surface of the host cell Cancer patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b8d743fb52bdefabd4cd379d833ba0
http://europepmc.org/articles/PMC8282443
http://europepmc.org/articles/PMC8282443
Autor:
Sivakama S. Bharathi, Yuxun Zhang, Takuto Chiba, Nathan Basisty, Eric S. Goetzman, Sunder Sims-Lucas, Kasey R Cargill, Kevin Peasley, Elina Mukherjee, Anja Holtz, Katherine Maringer, Birgit Schilling, Shiva D Yagobian
Publikováno v:
J Am Soc Nephrol
BACKGROUND: The primary site of damage during AKI, proximal tubular epithelial cells, are highly metabolically active, relying on fatty acids to meet their energy demands. These cells are rich in mitochondria and peroxisomes, the two organelles that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3598e421ee3dff3a85a636fd98a1e9ee
https://doi.org/10.1681/asn.2019020163
https://doi.org/10.1681/asn.2019020163