Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Kasem Nithipatikom"'
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 10, Pp 2093-2102 (2014)
Microsomal epoxide hydrolase (EPHX1, EC 3.3.2.9) is a highly abundant α/β-hydrolase enzyme that is known for its catalytical epoxide hydrolase activity. A wide range of EPHX1 functions have been demonstrated including xenobiotic metabolism; however
Externí odkaz:
https://doaj.org/article/5d68b6dd51d048b6a99e1c31d76818d1
Autor:
Anna Hsu, Marketa Hlavackova, Dita Sotakova-Kasparova, Abdul H. Khan, Kasem Nithipatikom, Michaela Cyprová, Garrett J. Gross, John R. Falck, Jan Neckář, John D. Imig, František Kolář, Daniel Benák, David Sedmera
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 315:H1148-H1158
Epoxyeicosatrienoic acids (EETs) decrease cardiac ischemia-reperfusion injury; however, the mechanism of their protective effect remains elusive. Here, we investigated the cardioprotective action of a novel EET analog, EET-B, in reperfusion and the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09dfbf007c105d6348df707c27a097da
https://doi.org/10.1152/ajpheart.00726.2017
https://doi.org/10.1152/ajpheart.00726.2017
Autor:
Alan T. Tang, Adam W. Pfeiffer, Ana Doris Gomez-Granados, William B. Campbell, Kasem Nithipatikom, Carol L. Williams
Publikováno v:
Endocrinology. 153:29-41
The cannabinoid receptor type 1 (CB1) is a G protein-coupled receptor that is activated in an autocrine fashion by the endocannabinoids (EC), N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG). The CB1 and its endogenous and synthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4318c4b2cb64adc61b933959682657eb
https://doi.org/10.1210/en.2011-1144
https://doi.org/10.1210/en.2011-1144
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 300:H2064-H2071
This study explored the hypothesis that a portion of angiotensin II-induced contractions is dependent on superoxide generation and release of a previously unidentified arachidonic acid metabolite that activates vascular smooth muscle thromboxane rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8a8523de5bee009802f0584916b500
https://doi.org/10.1152/ajpheart.01135.2010
https://doi.org/10.1152/ajpheart.01135.2010
Autor:
Marilyn A. Isbell, Jeffrey Woodliff, Michael P. Endsley, William B. Campbell, Kasem Nithipatikom
Publikováno v:
Prostaglandins & Other Lipid Mediators. 94:34-43
Endocannabinoids (ECs), anandamide (AEA) and 2-arachidonoylglycerol (2-AG), inhibit proliferation of carcinoma cells. Several enzymes hydrolyze ECs to reduce endogenous EC concentrations and produce eicosanoids that promote cell growth. In this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fc118955269f7d98d30dd3c27583ed
https://doi.org/10.1016/j.prostaglandins.2010.12.002
https://doi.org/10.1016/j.prostaglandins.2010.12.002
Autor:
John R. Falck, Vijaya L. Manthati, Alan T. Tang, Daniel M. Brody, Carol L. Williams, William B. Campbell, Kasem Nithipatikom
Publikováno v:
Cancer Science. 101:2629-2636
Cytochrome P450 (CYP) epoxygenases, CYP2C8, 2C9 and 2J2 mRNA and proteins, were expressed in prostate carcinoma (PC-3, DU-145 and LNCaP) cells. 11,12-Epoxyeicosatrienoic acid (11,12-EET) was the major arachidonic acid metabolite in these cells. Block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad6ca5280a53c440e0ef82170c99ed6
https://doi.org/10.1111/j.1349-7006.2010.01713.x
https://doi.org/10.1111/j.1349-7006.2010.01713.x
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 298:H2201-H2207
We previously demonstrated that several epoxyeicosatrienoic acids (EETs) produce reductions in myocardial infarct size in rats and dogs. Since a recent study demonstrated the release of opioids in mediating the antinociceptive effect of 14,15-EET, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c29bd58652faa6ecfc1f4a93d826030
https://doi.org/10.1152/ajpheart.00815.2009
https://doi.org/10.1152/ajpheart.00815.2009
Autor:
Kathryn M. Gauthier, John R. Falck, David X. Zhang, William B. Campbell, Kasem Nithipatikom, Phillip G. Kopf, Xiu Yu Yi
Publikováno v:
Hypertension. 55:547-554
Adrenic acid (docosatetraenoic acid), an abundant fatty acid in the adrenal gland, is identical to arachidonic acid except for 2 additional carbons on the carboxyl end. Adrenic acid is metabolized by cyclooxygenases, cytochrome P450s, and lipoxygenas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c9aa0aa878c51c4e8bb4b7f89a547e
https://doi.org/10.1161/hypertensionaha.109.144147
https://doi.org/10.1161/hypertensionaha.109.144147
Autor:
Kathryn M. Gauthier, William B. Campbell, Kasem Nithipatikom, Garrett J. Gross, Jeannine Moore, John R. Falck
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 297:H47-H52
Cytochrome P-450 (CYP) epoxygenases and their arachidonic acid (AA) metabolites, the epoxyeicosatrienoic acids (EETs), have been shown to produce marked reductions in infarct size (IS) in canine myocardium either given before an ischemic insult or at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9314c8d24d428a8de0b06dcc02b3436
https://doi.org/10.1152/ajpheart.01084.2008
https://doi.org/10.1152/ajpheart.01084.2008
Autor:
Åsa M. Wheelock, Susanna L. Lundström, Craig E. Wheelock, Fabio Luiz D’Alexandri, Kasem Nithipatikom, Jesper Z. Haeggström
Publikováno v:
Methods in Molecular Biology
Methods in Molecular Biology ISBN: 9781607613213
Methods in Molecular Biology ISBN: 9781607613213
Eicosanoids are oxygenated, endogenous, unsaturated fatty acids derived from arachidonic acid. Detection and quantification of these compounds are of great interest because they play important roles in a number of significant diseases, including asth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0449c80bc311760c69bf79e21597685f