Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Karyn McFadden"'
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87299 (2014)
B-cell activation and proliferation can be induced by a variety of extracellular stimuli. The fate of an activated B cell following mitogen stimulation can be dictated by the strength or duration of the signal, the expression of downstream signaling
Externí odkaz:
https://doaj.org/article/ccc97e00edf3476d84f611b0175c2a3e
Autor:
Wadim L Matochko, Constantin Nelep, Weihsu C Chen, Stephanie Grauer, Karyn McFadden, Vicki Wilson, Kirill Oxenoid
Publikováno v:
Antibody Therapeutics
The most robust strategy in antibody discovery is the use of immunized animals and the ability to isolate and immortalize immune B-cells to hybridoma for further interrogation. However, capturing the full repertoire of an immunized animal is labor in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea7c7d7993a67c2c41909dd6f641d71
https://doi.org/10.1093/abt/tbab030
https://doi.org/10.1093/abt/tbab030
Autor:
John Bergen, Julius Landas, Anthony Gonzalez, Christopher Murawsky, Karyn McFadden, Hossein Salimi-Moosavi, Chadwick T. King, Aaron George Winters, Philip Tagari, Kelly A Berry
Publikováno v:
mAbs
Accelerated development of monoclonal antibody (mAb) tool reagents is an essential requirement for the successful advancement of therapeutic antibodies in today’s fast-paced and competitive drug development marketplace. Here, we describe a direct,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4880bc4b96c04285ce0e399f9985f4b0
http://europepmc.org/articles/PMC6748590
http://europepmc.org/articles/PMC6748590
Autor:
Kantharaju Kamanna, Irwin Chaiken, Ramalingam Venkat Kalyana Sundaram, Charles G. Ang, Caitlin Duffy, Yu-Hung Huang, Karyn McFadden, Arangassery Rosemary Bastian, Farida Shaheen, Lauren D. Bailey
Publikováno v:
Virus research. 235
HIV-1 Env protein is essential for host cell entry, and targeting Env remains an important antiretroviral strategy. We previously found that a peptide triazole thiol KR13 and its gold nanoparticle conjugate AuNP-KR13 directly and irreversibly inactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2edcfeba0943266bbf302d36873484
https://pubmed.ncbi.nlm.nih.gov/28390972
https://pubmed.ncbi.nlm.nih.gov/28390972
Autor:
Joshua E. Messinger, Jeffrey C. Rathmell, Micah A. Luftig, Rigel J. Kishton, Pavel A. Nikitin, Amy Y Hafez, Karyn McFadden
Publikováno v:
Proceedings of the National Academy of Sciences. 113
Epstein-Barr virus (EBV) is an oncogenic herpesvirus that has been causally linked to the development of B-cell and epithelial malignancies. Early after infection, EBV induces a transient period of hyperproliferation that is suppressed by the activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee64fd70c55d5fde0c088ba8a673379e
https://doi.org/10.1073/pnas.1517141113
https://doi.org/10.1073/pnas.1517141113
Autor:
Elizabeth C. Upton, Karyn McFadden, Navid Madani, Andrew P. Holmes, Isaac Zentner, Ferit Tuzer, Srivats Rajagopal, Kantharaju Kamanna, Judith M. LaLonde, Joseph Sodroski, Mark Contarino, Irwin Chaiken
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 81:271-290
Despite advances in HIV therapy, viral resistance and side-effects with current drug regimens require targeting new components of the virus. Dual antagonist peptide triazoles (PT) are a novel class of HIV-1 inhibitors that specifically target the gp1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8251c3ad61ef12690aca928f21414ab8
https://doi.org/10.1002/prot.24184
https://doi.org/10.1002/prot.24184
Autor:
Srivats Rajagopal, Dimiter S. Dimitrov, Syna Kuriakose Gift, Karyn McFadden, Isaac Zentner, Irwin Chaiken, Mei-Yun Zhang
Publikováno v:
Biochemistry. 50:2769-2779
We sought to identify sequences in the monoclonal antibody m18 complementarity determining regions (CDRs) that are responsible for its interaction with HIV-1 gp120 and inhibition of the envelope receptor binding sites. In the accompanying paper (DOI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d180bfc2ecd5fa3989bad6b42083ae18
https://doi.org/10.1021/bi101161j
https://doi.org/10.1021/bi101161j
Autor:
Neena Philips, Karyn McFadden
Publikováno v:
Cancer Letters. 206:63-68
Hormones, estrogen and prolactin, transforming growth factor-beta (TGF-beta), and matrixmetalloproteinases (MMPs) may modulate breast cancer progression. The goal of this research was to examine the regulation of expression of TGF-beta and MMPs (MMP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a6006a15af03e3c188d79737c8338e
https://doi.org/10.1016/j.canlet.2003.10.019
https://doi.org/10.1016/j.canlet.2003.10.019
Autor:
Jeffrey M. Jacobson, Caitlin Duffy, Karyn McFadden, Lauren D. Bailey, Rachna Aneja, James A. Hoxie, Mark Contarino, Irwin Chaiken, Kevin J. Freedman, George J. Leslie, Diogo Rodrigo Magalhães Moreira, Arangassery Rosemary Bastian, Ali Emileh
Publikováno v:
Retrovirology
Background We examined the underlying mechanism of action of the peptide triazole thiol, KR13 that has been shown previously to specifically bind gp120, block cell receptor site interactions and potently inhibit HIV-1 infectivity. Results KR13, the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d869822c92ae559e8c60c80b7e2fb05b
https://doi.org/10.1186/1742-4690-10-153
https://doi.org/10.1186/1742-4690-10-153
Autor:
Micah A. Luftig, Karyn McFadden
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 9783642377648
Viruses encounter many challenges within host cells in order to replicate their nucleic acid. In the case of DNA viruses, one challenge that must be overcome is recognition of viral DNA structures by the host DNA damage response (DDR) machinery. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc168c58c94d6849d9b6f8667f02ab0
https://doi.org/10.1007/978-3-642-37765-5_9
https://doi.org/10.1007/978-3-642-37765-5_9
