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of 34
pro vyhledávání: '"Karyn M. Myers"'
Publikováno v:
Neuroscience Letters. 541:39-42
Maladaptive conditioned responses (CRs) contribute to psychiatric disorders including anxiety disorders and addiction. Methods of reducing these CRs have been considered as possible therapeutic approaches. One such method is extinction, which involve
Publikováno v:
Nature Protocols. 7:517-526
Conditioned opiate withdrawal contributes to relapse in addicts and can be studied in rats using the opiate withdrawal-induced conditioned place aversion (OW-CPA) paradigm. Attenuation of conditioned withdrawal through extinction may be beneficial in
Autor:
David C. Wong-Faull, T.C. Tai, Karyn M. Myers, Edward G. Meloni, Dona L. Wong, William A. Carlezon, Robert Claycomb, Richard Kvetnansky
Publikováno v:
Cellular and Molecular Neurobiology. 32:737-748
Epinephrine (Epi), which initiates short-term responses to cope with stress, is, in part, stress-regulated via genetic control of its biosynthetic enzyme, phenylethanolamine N-methyltransferase (PNMT). In rats, immobilization (IMMO) stress activates
Autor:
William A. Carlezon, Karyn M. Myers
Publikováno v:
Neuroscience & Biobehavioral Reviews. 35:285-302
Conditioned drug craving and withdrawal elicited by cues paired with drug use or acute withdrawal are among the many factors contributing to compulsive drug taking. Understanding how to stop these cues from having these effects is a major goal of add
Autor:
Ana M. Fiallos, Seth D. Norrholm, Tanja Jovanovic, Erica Duncan, Megan Keyes, Michael Davis, Jennifer E. Fennell, Karyn M. Myers
Publikováno v:
Psiquiatría Biológica. 17:119-126
Resumen Uno de los problemas clave que se plantean en el trastorno de estres postraumatico (TEPT) es la incapacidad de inhibir el temor, incluso estando en unas condiciones seguras. Los fundamentos neurales que subyacen en el temor son clinicamente r
Autor:
Dennis C. Choi, Karyn M. Myers, Kerry J. Ressler, Kimberly A. Maguschak, Keqiang Ye, Sung-Wuk Jang
Publikováno v:
Proceedings of the National Academy of Sciences. 107:2675-2680
In the medial prefrontal cortex, the prelimbic area is emerging as a major modulator of fear behavior, but the mechanisms remain unclear. Using a selective neocortical knockout mouse, virally mediated prelimbic cortical-specific gene deletion, and ph
Autor:
Jidong Guo, Rimi Hazra, Donald G. Rainnie, Karyn M. Myers, Sayamwong E. Hammack, Joanna Dabrowska
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 33:1309-1320
Substantial evidence has suggested that the activity of the bed nucleus of the stria terminalis (BNST) mediates many forms of anxiety-like behavior in human and non-human animals. These data have led many investigators to suggest that abnormal proces
Autor:
Tanja Jovanovic, Erica Duncan, William Boshoven, Michael Davis, Karyn M. Myers, Barbara O. Rothbaum, Seth D. Norrholm, Bram Vervliet
Publikováno v:
Behavioral Neuroscience, 122(5), 1016-1030. American Psychological Association
Fear extinction is a reduction in conditioned fear responses following repeated exposure to the feared cue in the absence of any aversive event. Exposure treatments for anxiety disorders such as posttraumatic stress disorder can be conceptualized as
Autor:
Tanja Jovanovic, Michael Davis, Barbara O. Rothbaum, Bram Vervliet, Seth D. Norrholm, Erica Duncan, Karyn M. Myers
Publikováno v:
Learning & Memory, 13, 681-685. Cold Spring Harbor Laboratory Press
The purpose of this study was to analyze fear extinction and reinstatement in humans using fear-potentiated startle. Participants were fear conditioned using a simple discrimination procedure with colored lights as the conditioned stimuli (CSs) and a
Publikováno v:
Annals of the New York Academy of Sciences. 985:218-232
Although much is now known about the neural basis of excitatory fear conditioning, much less is known about the neural basis of inhibitory conditioning. One type of inhibitory conditioning is extinction, a process in which stimuli that elicit fear by