Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Karyn L. Mlodnosky"'
Publikováno v:
The Journal of Organic Chemistry. 64:8698-8701
Autor:
Chester E. Rodriguez, Clifford E. Berkman, H. Michael Holmes, Karyn L. Mlodnosky, Vinh Q. Lam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:1521-1524
Several putative, phosphorus-containing inhibitors of γ-glutamyl hydrolase were synthesized and evaluated for inhibitory activity. The phosphonamidoic acids were shown to be weak competitive inhibitors while both a phosphoramidate diester and a phos
Publikováno v:
Tetrahedron Letters. 38:8803-8806
Phosphonamidates are formed in high yield from a one-pot sequential reaction of a phosphonyl dichloride with an alcohol and then an amine in the presence of catalytic 1H-tetrazole. Undesired disubstitution of the phoshphonyl dichloride by the alcohol
Publikováno v:
ChemInform. 29
Publikováno v:
ChemInform. 29
Autor:
Clifford E. Berkman, Azar Dastgah, Karyn L. Mlodnosky, Haiyan Lu, Trang T. Dinh, Chester E. Rodriguez, C. Blake Nichols, Vinh Q. Lam
Publikováno v:
ChemInform. 30
Autor:
Chester E. Rodriguez, Clifford E. Berkman, Trang T. Ding, Azar Dastgah, Karyn L. Mlodnosky, Vinh Q. Lam, Haiyan Lu, C. Blake Nichols
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(10)
Several N-thiophosphonyl-glutamates were found to be potent competitive inhibitors of a zinc-dependent glutamyl hydrolase, carboxypeptidase G (CPG). Weak inhibition exhibited by an analogous N-phosphonyl-glutamate suggests that the enhanced potency o