Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Karyn A. Esser"'
Autor:
Mark R. Viggars, Hannah E. Berko, Stuart J. Hesketh, Christopher A. Wolff, Miguel A. Gutierrez-Monreal, Ryan A. Martin, Isabel G. Jennings, Zhiguang Huo, Karyn A. Esser
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101980- (2024)
Objective: In this investigation, we addressed the contribution of the core circadian clock factor, BMAL1, in skeletal muscle to both acute transcriptional responses to exercise and transcriptional remodeling in response to exercise training. Additio
Externí odkaz:
https://doaj.org/article/4f8165619b1142dbbf2096c2b599ae2d
Autor:
Bryan Alava, Gabriela Hery, Silvana Sidhom, Miguel Gutierrez-Monreal, Stefan Prokop, Karyn A. Esser, Jose Abisambra
Publikováno v:
Aging Brain, Vol 5, Iss , Pp 100110- (2024)
Tauopathies are neurodegenerative disorders in which the pathological intracellular aggregation of the protein tau causes cognitive deficits. Additionally, clinical studies report muscle weakness in populations with tauopathy. However, whether neuron
Externí odkaz:
https://doaj.org/article/ce017264e4004d64bf72b7e4f8bed441
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/3dca53486bc14c42b4e4ddf95f6e9ebe
Autor:
Christopher A. Wolff, Miguel A. Gutierrez-Monreal, Lingsong Meng, Xiping Zhang, Lauren G. Douma, Hannah M. Costello, Collin M. Douglas, Elnaz Ebrahimi, Ann Pham, Aline C. Oliveira, Chunhua Fu, Amy Nguyen, Bryan R. Alava, Stuart J. Hesketh, Andrew R. Morris, Mehari M. Endale, G. Ryan Crislip, Kit-yan Cheng, Elizabeth A. Schroder, Brian P. Delisle, Andrew J. Bryant, Michelle L. Gumz, Zhiguang Huo, Andrew C. Liu, Karyn A. Esser
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111982- (2023)
Summary: Cellular circadian clocks direct a daily transcriptional program that supports homeostasis and resilience. Emerging evidence has demonstrated age-associated changes in circadian functions. To define age-dependent changes at the systems level
Externí odkaz:
https://doaj.org/article/2f18b4dcc2854c8b81ce1f23e09506dc
Autor:
Venugopalan D. Nair, Mital Vasoya, Vishnu Nair, Gregory R. Smith, Hanna Pincas, Yongchao Ge, Collin M. Douglas, Karyn A. Esser, Stuart C. Sealfon
Publikováno v:
MethodsX, Vol 9, Iss , Pp 101681- (2022)
ATAC-seq is a fast and sensitive method for the epigenomic profiling of open chromatin and for mapping of transcription factor binding sites [1]. Despite the development of the Omni-ATAC protocol for the profiling of chromatin accessibility in frozen
Externí odkaz:
https://doaj.org/article/230c6c9f8a2a426ba34088c697d8b42b
Autor:
Elizabeth A. Schroder, Jennifer L. Wayland, Kaitlyn M. Samuels, Syed F. Shah, Don E. Burgess, Tanya Seward, Claude S. Elayi, Karyn A. Esser, Brian P. Delisle
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Circadian rhythms are generated by cell autonomous circadian clocks that perform a ubiquitous cellular time-keeping function and cell type-specific functions important for normal physiology. Studies show inducing the deletion of the core circadian cl
Externí odkaz:
https://doaj.org/article/ea6c48d6d60645a3a585e7b0a362a96a
Autor:
Kazunari Nohara, Venkata Mallampalli, Travis Nemkov, Marvin Wirianto, Jiah Yang, Youqiong Ye, Yuxiang Sun, Leng Han, Karyn A. Esser, Eugenia Mileykovskaya, Angelo D’Alessandro, Carla B. Green, Joseph S. Takahashi, William Dowhan, Seung-Hee Yoo, Zheng Chen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The small molecule Nobiletin enhances circadian rhythms and protects against obesity-associated metabolic dysfunction in mice. Here the authors test its effect on health and lifespan, reporting that circadian enhancement promotes fitness and healthy
Externí odkaz:
https://doaj.org/article/a785be3a47764eeebef82872ff3d00a8
Autor:
Lance T. Denes, Lance A. Riley, Joseph R. Mijares, Juan D. Arboleda, Kendra McKee, Karyn A. Esser, Eric T. Wang
Publikováno v:
Skeletal Muscle, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Background Skeletal muscle contributes to roughly 40% of lean body mass, and its loss contributes to morbidity and mortality in a variety of pathogenic conditions. Significant insights into muscle function have been made using cultured cells
Externí odkaz:
https://doaj.org/article/2638f220d5fa472eb7f0b24cea773c51
Autor:
Gene Ryan Crislip, Stephanie E. Wohlgemuth, Christopher A. Wolff, Miguel A. Gutierrez-Monreal, Collin M. Douglas, Elnaz Ebrahimi, Kit-Yan Cheng, Sarah H. Masten, Dominique Barral, Andrew J. Bryant, Karyn A. Esser, Michelle L. Gumz
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 261 (2022)
BMAL1 is a core mammalian circadian clock transcription factor responsible for the regulation of the expression of thousands of genes. Previously, male skeletal-muscle-specific BMAL1-inducible-knockout (iMS-BMAL1 KO) mice have been described as a mod
Externí odkaz:
https://doaj.org/article/b478ab60a791410b8896f97c86721efd
Autor:
Rosaly Correa-de-Araujo, Odessa Addison, Iva Miljkovic, Bret H. Goodpaster, Bryan C. Bergman, Richard V. Clark, Joanne W. Elena, Karyn A. Esser, Luigi Ferrucci, Michael O. Harris-Love, Steve B. Kritchevsky, Amanda Lorbergs, John A. Shepherd, Gerald I. Shulman, Clifford J. Rosen
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Skeletal muscle fat infiltration (known as myosteatosis) is an ectopic fat depot that increases with aging and is recognized to negatively correlate with muscle mass, strength, and mobility and disrupt metabolism (insulin resistance, diabetes). An in
Externí odkaz:
https://doaj.org/article/8f5c671a2db841feae7bac121af5d86b