Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Karuppiah Muthumani"'
Autor:
Emma L Reuschel, JiangFang Wang, Debra K Shivers, Karuppiah Muthumani, David B Weiner, Zhengyu Ma, Terri H Finkel
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136323 (2015)
REDD1 is a highly conserved stress response protein that is upregulated following many types of cellular stress, including hypoxia, DNA damage, energy stress, ER stress, and nutrient deprivation. Recently, REDD1 was shown to be involved in dexamethas
Externí odkaz:
https://doaj.org/article/178d64df3b594bf88c2aebe3687c537d
Autor:
Joo-Sung Yang, Mathura P. Ramanathan, Karuppiah Muthumani, Andrew Y. Choo, Sung-Ha Jin, Qian-Chun Yu, Daniel S. Hwang, Daniel K. Choo, Mark D. Lee, Kesen Dang, J. Joseph Kim, David B. Weiner
Publikováno v:
Emerging Infectious Diseases, Vol 8, Iss 12, Pp 1379-1384 (2002)
West Nile virus (WNV) is a member of the Flaviviridae family of vector-borne pathogens. Clinical signs of WNV infection include neurologic symptoms, limb weakness, and encephalitis, which can result in paralysis or death. We report that the WNV-capsi
Externí odkaz:
https://doaj.org/article/0c8a339d17b446478a1a121765ae7d18
Autor:
Karthik Mallilankaraman, Devon J Shedlock, Huihui Bao, Omkar U Kawalekar, Paolo Fagone, Aarthi A Ramanathan, Bernadette Ferraro, Jennifer Stabenow, Paluru Vijayachari, Senthil G Sundaram, Nagarajan Muruganandam, Gopalsamy Sarangan, Padma Srikanth, Amir S Khan, Mark G Lewis, J Joseph Kim, Niranjan Y Sardesai, Karuppiah Muthumani, David B Weiner
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 5, Iss 1, p e928 (2011)
Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus indigenous to tropical Africa and Asia. Acute illness is characterized by fever, arthralgias, conjunctivitis, rash, and sometimes arthritis. Relatively little is known about the antig
Externí odkaz:
https://doaj.org/article/5c41fd311157407db58e69ca49dd0aa8
Autor:
Michelle M Thiboutot, Senthil Kannan, Omkar U Kawalekar, Devon J Shedlock, Amir S Khan, Gopalsamy Sarangan, Padma Srikanth, David B Weiner, Karuppiah Muthumani
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 4, p e623 (2010)
Chikungunya virus is a mosquito-borne emerging pathogen that has a major health impact in humans and causes fever disease, headache, rash, nausea, vomiting, myalgia, and arthralgia. Indigenous to tropical Africa, recent large outbreaks have been repo
Externí odkaz:
https://doaj.org/article/fc2a9ccfc4d84bdca1a346f367f5d2b2
Autor:
Prashanthi Vonteddu, Rishabh Sharma, Aaron R. Goldman, Hsin-Yao Tang, Hyeree Choi, Farokh Dotiwala, Kumar Sachin Singh, Karuppiah Muthumani, Anjana Sundarrajan, Andrew V. Kossenkov, Maureen E. Murphy, Joseph M. Salvino, Madeline Good, Poli Adi Narayana Reddy, Maxim Totrov, Joel Cassel, Rajasekharan Somasundaram, Meenhard Herlyn
Publikováno v:
Nature. 589:597-602
Isoprenoids are vital for all organisms, in which they maintain membrane stability and support core functions such as respiration1. IspH, an enzyme in the methyl erythritol phosphate pathway of isoprenoid synthesis, is essential for Gram-negative bac
Autor:
Karuppiah Muthumani, Laurent Humeau, Xizhou Zhu, David B. Weiner, Makan Khoshnejad, Rehman Qureshi, Ami Patel, Yaya Dia, Ziyang Xu, Kun Yun, Krzysztof Wojtak
Publikováno v:
Nucleic Acid Therapeutics. 30:379-391
Hyperammonemia is a dangerous life-threatening metabolic complication characterized by markedly elevated ammonia levels that can lead to irreversible brain damage if not carefully monitored. Current pharmacological treatment strategies available for
Autor:
David B. Weiner, Laurent Humeau, Jian Yan, Trevor R.F. Smith, Holly Pugh, Katherine Schultheis, Jing Chen, Janet Oh, Jacklyn Nguyen, Bryan S. Yung, Karuppiah Muthumani, Neil Cooch, Charles C. Reed, Kate E. Broderick
Publikováno v:
Human Vaccines & Immunotherapeutics
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Respiratory Syncytial virus (RSV) is a major threat to many vulnerable populations. There are currently no approved vaccines, and RSV remains a high unmet global medical need. Here we describe the employment of a novel synthetic DNA-encoded antibody
Autor:
Makan Khoshnejad, Urvi S Zankharia, Hyeree Choi, Sagar B. Kudchodkar, Faraz I. Zaidi, Michelle Ho, David B. Weiner, Karuppiah Muthumani, Alfredo Perales-Puchalt, Joseph Kim, Kenneth E. Ugen
Publikováno v:
Human Vaccines & Immunotherapeutics
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Hepatitis B virus (HBV) causes a potentially life-threatening liver infection that frequently results in life-long chronic infection. HBV is responsible for 887,000 deaths each year, most resulting from chronic liver diseases and hepatocellular carci
Autor:
Gayathri Gulendran, David B. Weiner, Charles C. Reed, Sagar B. Kudchodkar, Kanika Asija, Hyeree Choi, Karuppiah Muthumani, Lucas Van Gorder, Sangya Agarwal, Piyush Borole, Don L. Siegel, Emma L. Reuschel, J. Joseph Kim, Stephanie Ramos, Kenneth E. Ugen, Gary P. Kobinger, Kate E. Broderick
Publikováno v:
Human Vaccines & Immunotherapeutics
Significant concerns have arisen over the past 3 y from the increased global spread of the mosquito-borne flavivirus, Zika. Accompanying this spread has been an increase in cases of the devastating birth defect microcephaly as well as of Guillain–B
Autor:
David I. Shreiber, Emran O. Lallow, Sagar B. Kudchodkar, Moonsup Jeong, Jerry W. Shan, Young K. Park, Christine C. Roberts, Joel N. Maslow, Jonathan P. Singer, Juliet M. Melnik, Ijaz Ahmed, Hao Lin, Jeffrey D. Zahn, Karuppiah Muthumani, Nandita C. Jhumur, Sarah H. Park
Publikováno v:
Science Advances
Description
Suction-mediated cutaneous DNA uptake yielded high in vivo efficiency and thus provides an alternative transfection platform.
This work reports a suction-based cutaneous delivery method for in vivo DNA transfection. Following in
Suction-mediated cutaneous DNA uptake yielded high in vivo efficiency and thus provides an alternative transfection platform.
This work reports a suction-based cutaneous delivery method for in vivo DNA transfection. Following in