Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Karuppagounder S. Saravanan"'
Autor:
Karuppagounder S. Senthilkumar, Karuppagounder S. Saravanan, A. Jayakrishnan, Kochupurackal P. Mohanakumar, Goutam Chandra, Kizhakke M. Sindhu
Publikováno v:
Behavioural Brain Research. 184:11-18
Dopaminergic functional recovery following controlled release of dopamine from biodegradable polymer matrices implanted in the lesioned striatum was investigated in a hemiparkinsonian animal model. Significant dopamine depletion in the striatum ipsil
Autor:
Rebecca Banerjee, Bobby Thomas, Karuppagounder S. Saravanan, Kizhake M. Sindhu, Kochupurackal P. Mohanakumar
Publikováno v:
Neurochemical Research. 33:985-995
In the present study we provide evidence for hydroxyl radical (*OH) scavenging action of nitric oxide (NO*), and subsequent dopaminergic neuroprotection in a hemiparkinsonian rat model. Reactive oxygen species are strongly implicated in the nigrostri
Publikováno v:
Life Sciences. 79:2269-2274
Hepatic tryptophan 2,3-dioxygenase (TDO) is one of the rate-limiting enzymes in tryptophan catabolism and plays an important role in regulating the physiological flux of tryptophan into relevant metabolic pathways. In this study, we determined the ef
Autor:
Karuppagounder S. Senthilkumar, Rebecca Banerjee, Kizhakke M. Sindhu, Karuppagounder S. Saravanan, Kochupurackal P. Mohanakumar, J. Madhusudan Rao, B. China Raju
Publikováno v:
Pharmacology Biochemistry and Behavior. 84:321-329
Rotenone and 1-methyl-4-phenyl pyridinium (MPP + ) are two mitochondrial neurotoxins known to produce Parkinson's disease (PD) in experimental animals. In the present study, we compared drug-induced rotational asymmetry in rats lesioned using these n
Publikováno v:
Brain Research. 966:245-252
We evaluated the hydroxyl radical (*OH) scavenging action of nonsteroidal anti-inflammatory drugs (NSAIDs), sodium salicylate (SA), diclofenac and celecoxib in Fenton's reaction and their neuroprotective effects in 1-methyl-4-phenylpyridinium (MPP(+)
Publikováno v:
Neurochemistry international. 52(6)
The neuronal nitric oxide synthase (nNOS) inhibitor, 7-nitroindazole (7-NI) is neuroprotective against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Monoamine oxidase (MAO)-B inhibitory action partially contributes to this
Publikováno v:
Journal of pineal research. 42(3)
In the present study, we evaluated the effect of melatonin, a well-known free radical scavenger and neuroprotector, against rotenone-induced oxidative stress in a hemiparkinsonian rat model. The effect of melatonin on glutathione (GSH) depletion caus
Autor:
Sen Sreetama, Rebecca Banerjee, Sailendra Nath Dey, Kochupurackal P. Mohanakumar, Karuppagounder S. Saravanan
Publikováno v:
Neurochemical research. 32(7)
The potent parkinsonian neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is known to cause dopaminergic neurodegeneration in nigrostriatal system. In the present study we investigated the nuclear morphology of cells in the substantia
Autor:
Kochupurackal P. Mohanakumar, Rebecca Banerjee, Sen Sreetama, Karuppagounder S. Saravanan, Goutam Chandra, Sailendra Nath De
Publikováno v:
Journal of chemical neuroanatomy. 32(2-4)
The potent Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is known to destroy dopaminergic neurons of the basal ganglia. Its neurotoxically active metabolite, 1-methyl-4-phenyl pyridinium (MPP(+)), has been examined in the prese
Autor:
Kizhakke M. Sindhu, Karuppagounder S. Senthilkumar, Kochupurackal P. Mohanakumar, Karuppagounder S. Saravanan
Publikováno v:
Neurochemistry international. 49(1)
The present study investigated oxidative damage and neuroprotective effect of the antiparkinsonian drug, L-deprenyl in neuronal death produced by intranigral infusion of a potent mitochondrial complex-I inhibitor, rotenone in rats. Unilateral stereot