Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Karunakaran A. Kalesh"'
Autor:
Pavan K. Mantravadi, Karunakaran A. Kalesh, Renwick C. J. Dobson, André O. Hudson, Anutthaman Parthasarathy
Publikováno v:
Antibiotics, Vol 8, Iss 1, p 8 (2019)
Pathogenic antibiotic resistant bacteria pose one of the most important health challenges of the 21st century. The overuse and abuse of antibiotics coupled with the natural evolutionary processes of bacteria has led to this crisis. Only incremental a
Externí odkaz:
https://doaj.org/article/5db51c388ebd47ae8e06986197ddf5eb
Publikováno v:
Current Medicinal Chemistry. 28:6337-6357
Leishmaniasis, a complex disease caused by at least 20 species of unicellular parasites of the genus Leishmania, disproportionately affects impoverished regions of about 90 tropical and sub-tropical countries. Currently available antileishmanial ther
Autor:
Dorothea Fiedler, Brian S. Mantilla, Nathaniel W. Brown, Karunakaran A. Kalesh, Roberto Docampo
Publikováno v:
Molecular Microbiology. 115:986-1004
Diphosphoinositol-5-pentakisphosphate (5-PP-IP5 ), also known as inositol heptakisphosphate (5-IP7 ), has been described as a high-energy phosphate metabolite that participates in the regulation of multiple cellular processes through protein binding
Autor:
Karunakaran A. Kalesh, Paul W. Denny
Publikováno v:
Expert Review of Proteomics. 17:789-792
In the post-genomic era, genomic and transcriptomic techniques have significantly advanced our understanding of the fundamental genetic aspects of many human diseases. However, these techniques hav...
Publikováno v:
RSC Medicinal Chemistry
This review highlights the key roles of proteomic techniques in the study of Leishmania spp., Trypanosoma cruzi and Trypanosoma brucei parasites.
Mass spectrometry-based proteomics enables accurate measurement of the modulations of proteins on a
Mass spectrometry-based proteomics enables accurate measurement of the modulations of proteins on a
Publikováno v:
Current Medicinal Chemistry. 26:2330-2355
Peptide therapeutics has made tremendous progress in the past decade. Many of the inherent weaknesses of peptides which hampered their development as therapeutics are now more or less effectively tackled with recent scientific and technological advan
Autor:
Dorian O. Haskard, Ambrosius P. Snijders, Aaron J. Borg, Anthony K.L. Leung, Saulius Lukauskas, Vinay Ayyappan, Peter A. DiMaggio, Karunakaran A. Kalesh
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific reports, 2019, Vol.9, pp.6655 [Peer Reviewed Journal]
Scientific Reports
Scientific reports, 2019, Vol.9, pp.6655 [Peer Reviewed Journal]
ADP-ribosylation is integral to a diverse range of cellular processes such as DNA repair, chromatin regulation and RNA processing. However, proteome-wide investigation of its cellular functions has been limited due to numerous technical challenges in
Autor:
Paul W. Denny, Karunakaran A. Kalesh
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS neglected tropical diseases, 2019, Vol.13(12), pp.e0007651 [Peer Reviewed Journal]
PLoS Neglected Tropical Diseases, Vol 13, Iss 12, p e0007651 (2019)
PLoS neglected tropical diseases, 2019, Vol.13(12), pp.e0007651 [Peer Reviewed Journal]
PLoS Neglected Tropical Diseases, Vol 13, Iss 12, p e0007651 (2019)
Adaptation to starvation is integral to the Leishmania life cycle. The parasite can survive prolonged periods of nutrient deprivation both in vitro and in vivo. The identification of parasite proteins synthesised during starvation is key to unravelli
Autor:
Han-Ming Shen, W.S. Fred Wong, Karunakaran A. Kalesh, Chengchao Xu, Yingke He, Jigang Wang, Yin Kwan Wong, Qingsong Lin
Publikováno v:
Medicinal Research Reviews. 37:1492-1517
Artemisinin and its derivatives (collectively termed as artemisinins) are among the most important and effective antimalarial drugs, with proven safety and efficacy in clinical use. Beyond their antimalarial effects, artemisinins have also been shown
Autor:
Anutthaman Parthasarathy, Karunakaran A. Kalesh, Pavan K. Mantravadi, Renwick C. J. Dobson, André O. Hudson
Publikováno v:
Antibiotics
Antibiotics, Vol 8, Iss 1, p 8 (2019)
Antibiotics, 2019, Vol.8(1), pp.8 [Peer Reviewed Journal]
Antibiotics, Vol 8, Iss 1, p 8 (2019)
Antibiotics, 2019, Vol.8(1), pp.8 [Peer Reviewed Journal]
Pathogenic antibiotic resistant bacteria pose one of the most important health challenges of the 21st century. The overuse and abuse of antibiotics coupled with the natural evolutionary processes of bacteria has led to this crisis. Only incremental a