Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Karunai Leela Subramanian"'
Autor:
Fredrick O. Onono, Charles J. Waechter, Thangaiah Subramanian, Jeffrey S. Rush, Karunai Leela Subramanian, Hans Peter Spielmann
Publikováno v:
Current Chemical Biology. 9:123-141
Dolichyl phosphate-linked mono- and oligosaccharides (DLO) are essential intermediates in protein N-glycosylation, C- and O-mannosylation and GPI anchor biosynthesis. While many membrane proteins in the endoplasmic reticulum (ER) involved in the asse
Autor:
Manjula Sunkara, Fredrick O. Onono, Thangaiah Subramanian, Andrew J. Morris, H. Peter Spielmann, Karunai Leela Subramanian
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 56:370-375
A Wittig reaction employing Li(CD3)2CP(C6H5)3 was used to prepare d6-farnesol and d6-geranylgeraniol. Reductive amination of aniline-2,3,4,5,6-d5 was used to prepare the unnatural isoprenoid analogues d5-anilinogeraniol and d5-anilinofarnesol. All of
Autor:
Linda P. Dwoskin, Andrew M. Smith, Chang-Guo Zhan, Agripina G. Deaciuc, Guangrong Zheng, Kiran B. Siripurapu, Xiaoqin Huang, Karunai Leela Subramanian
Publikováno v:
Journal of Medicinal Chemistry. 56:1693-1703
The M5 muscarinic acetylcholine receptor is suggested to be a potential pharmacotherapeutic target for the treatment of drug abuse. We describe herein the discovery of a series of M5-preferring orthosteric antagonists based on the scaffold of 1,2,5,6
Autor:
Thangaiah Subramanian, June E. Pais, Carol A. Fierke, Karunai Leela Subramanian, Yuta Suzuki, Jerry M. Troutman, Suxia Liu, H. Peter Spielmann, Douglas A. Andres
Publikováno v:
Biochemistry. 51:8307-8319
Farnesylation is an important post-translational modification essential for the proper localization and function of many proteins. Transfer of the farnesyl group from farnesyl diphosphate (FPP) to proteins is catalyzed by protein farnesyltransferase
Autor:
Linda P. Dwoskin, Peter A. Crooks, A. Gabriela Deaciuc, Karunai Leela Subramanian, Zhenfa Zhang, Marharyta Pivavarchyk
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1420-1423
By linking two or three mecamylamine or 2,2,6,6-tetramethylpiperidine (TMP) molecules together via a linear lipophilic bis-methylene linker or a specially designed conformationally restricted tris-linker, a series of bis- and tris-tertiary amine anal
Autor:
Andrew J. Morris, Karunai Leela Subramanian, Thangaiah Subramanian, Fredrick O. Onono, Manjula Sunkara, Hongmei Ren, H. Peter Spielmann
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(18)
An efficient, diversity oriented synthesis of homoisoprenoid α-monofluorophosphonates utilizing electrophilic fluorination is presented along with their activity as inhibitors of PPAPDC2 family integral membrane lipid phosphatases. These novel phosp
Autor:
Andrew J. Morris, Thangaiah Subramanian, H. Peter Spielmann, Fredrick O. Onono, Manjula Sunkara, Karunai Leela Subramanian
Mammalian cells can use exogenous isoprenols to generate isoprenoid diphosphate substrates for protein isoprenylation, but the mechanism, efficiency, and biological importance of this process are not known. We developed mass spectrometry-based method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14431256215a5e659e1485fa3245c994
https://europepmc.org/articles/PMC3779739/
https://europepmc.org/articles/PMC3779739/