Humoral and cellular response to the third COVID-19 vaccination in patients with inborn errors of immunity or mannose-binding lectin deficiency : A prospective controlled open-label trial.

Autor: Vossen MG; Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Vienna, Austria.; Comprehensive Center for Infection Medicine, Medical University of Vienna, Austria (CCIM), Vienna, Austria., Kartnig F; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.; Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria., Mrak D; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.; Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria., Simader E; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.; Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria., Stiasny K; Center for Virology, Medical University of Vienna, Vienna, Austria.; Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria., Kain R; Medical University of Vienna, Clinical Institute for Pathology, Vienna, Austria.; Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria., Perkmann T; Clinical Institute for Laboratory Medicine, Medical University of Vienna, Vienna, Austria.; Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria., Haslacher H; Clinical Institute for Laboratory Medicine, Medical University of Vienna, Vienna, Austria.; Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria., Aberle JH; Center for Virology, Medical University of Vienna, Vienna, Austria.; Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria., Heinz LX; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.; Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria., Sieghart D; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.; Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria., Burgmann H; Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Vienna, Austria.; Comprehensive Center for Infection Medicine, Medical University of Vienna, Austria (CCIM), Vienna, Austria., Aletaha D; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.; Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria., Scheinecker C; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.; Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria., Bonelli M; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.; Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria., Göschl L; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. lisa.goeschl@meduniwien.ac.at.; Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria. lisa.goeschl@meduniwien.ac.at.

Publikováno v: Wiener klinische Wochenschrift [Wien Klin Wochenschr] 2024 Nov; Vol. 136 (21-22), pp. 598-607. Date of Electronic Publication: 2024 Oct 24.

A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity.

Autor: Boeszoermenyi A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Bernaleau L; Department of Immunobiology, University of Lausanne, Epalinges, Switzerland., Chen X; Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China., Kartnig F; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Xie M; Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China., Zhang H; Department of Immunobiology, University of Lausanne, Epalinges, Switzerland., Zhang S; Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China., Delacrétaz M; Department of Immunobiology, University of Lausanne, Epalinges, Switzerland., Koren A; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Hopp AK; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Dvorak V; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Kubicek S; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Aletaha D; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Yang M; Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.; Cryo-EM Facility Center, Southern University of Science & Technology, Shenzhen, Guangdong, China., Rebsamen M; Department of Immunobiology, University of Lausanne, Epalinges, Switzerland. manuele.rebsamen@unil.ch., Heinz LX; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria. leonhard.heinz@meduniwien.ac.at., Superti-Furga G; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. gsuperti@cemm.oeaw.ac.at.; Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria. gsuperti@cemm.oeaw.ac.at.

Publikováno v: Nature communications [Nat Commun] 2023 Oct 20; Vol. 14 (1), pp. 6626. Date of Electronic Publication: 2023 Oct 20.

The accelerated waning of immunity and reduced effect of booster in patients treated with bDMARD and tsDMARD after SARS-CoV-2 mRNA vaccination.

Autor: Tobudic S; Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria., Simader E; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Deimel T; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Straub J; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Kartnig F; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Heinz LX; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Mandl P; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Haslacher H; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria., Perkmann T; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria., Schneider L; Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria., Nothnagl T; Department of Second Medical, Lower Austrian Centre for Rheumatology, Korneuburg-Stockerau Hospital, Stockerau, Austria., Radner H; Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria., Winkler F; Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Burgmann H; Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria., Stiasny K; Center for Virology, Medical University of Vienna, Vienna, Austria., Novacek G; Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Reinisch W; Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Aletaha D; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Winkler S; Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria., Blüml S; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

Publikováno v: Frontiers in medicine [Front Med (Lausanne)] 2023 Feb 09; Vol. 10, pp. 1049157. Date of Electronic Publication: 2023 Feb 09 (Print Publication: 2023).

Accelerated waning of immune responses to a third COVID-19 vaccination in patients with immune-mediated inflammatory diseases.

Autor: Mrak D; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Austria., Kartnig F; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Austria., Sieghart D; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Austria., Simader E; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Austria., Radner H; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Austria., Mandl P; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Austria., Göschl L; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Austria., Hofer P; Department of Pathology, Medical University of Vienna, Vienna, Austria., Deimel T; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Austria., Gessl I; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Austria., Kain R; Department of Pathology, Medical University of Vienna, Vienna, Austria., Winkler S; Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine I, Medical University of Vienna, Austria., Smolen JS; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Austria., Perkmann T; Department of Laboratory Medicine, Medical University of Vienna, Austria., Haslacher H; Department of Laboratory Medicine, Medical University of Vienna, Austria., Aletaha D; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Austria., Heinz LX; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Austria. Electronic address: leonhard.heinz@meduniwien.ac.at., Bonelli M; Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Austria. Electronic address: michael.bonelli@meduniwien.ac.at.

Publikováno v: Journal of autoimmunity [J Autoimmun] 2023 Feb; Vol. 135, pp. 102981. Date of Electronic Publication: 2022 Dec 22.

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