Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kartik R. Roy"'
Autor:
Kartik R. Roy, Mohammad B. Uddin, Sagor C. Roy, Ronald A. Hill, John Marshall, Yu‐Teh Li, Jean Christopher Chamcheu, Hua Lu, Yong‐Yu Liu
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 11, Pp 653-667 (2020)
Abstract Glucosylceramide synthase (GCS) is a key enzyme catalyzing ceramide glycosylation to generate glucosylceramide (GlcCer), which in turn serves as the precursor for cells to produce glycosphingolipids (GSLs). In cell membranes, GSLs serve as e
Externí odkaz:
https://doaj.org/article/973d41d7eb66424a8dba340670718eb5
Autor:
Nhu Nguyen, Kristbjorn O. Gudmundsson, Anthony R. Soltis, Kevin Oakley, Kartik R. Roy, Yufen Han, Carmelo Gurnari, Jaroslaw P. Maciejewski, Gary Crouch, Patricia Ernst, Clifton L. Dalgard, Yang Du
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103679- (2022)
Summary: Abnormal activation of SETBP1 due to overexpression or missense mutations occurs frequently in various myeloid neoplasms and associates with poor prognosis. Direct activation of Hoxa9/Hoxa10/Myb transcription by SETBP1 and its missense mutan
Externí odkaz:
https://doaj.org/article/aec9793ae4a740d5aec5ddb6c0f79d33
Autor:
Sachin K. Khiste, Salman B. Hosain, Yixuan Dong, Mohammad B. Uddin, Kartik R. Roy, Ronald A. Hill, Zhijun Liu, Yong-Yu Liu
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Glucosylceramide synthase (GCS) is a rate-limiting enzyme catalyzing ceramide glycosylation, thereby regulating cellular ceramide levels and the synthesis of glycosphingolipids (GSLs) in cellular membranes. Alterations of GCS not only affect
Externí odkaz:
https://doaj.org/article/524f0c7128c14f34911c53c9faa60238
Autor:
Yong-Yu Liu, Ronald A. Hill, Sami Nazzal, Xin Gu, Salman B. Hosain, Mohammad B. Uddin, Kartik R. Roy, Zhijun Liu, Sachin K. Khiste
Supplementary Figure S1-S3- supplementary S1: The stability of Cer-RUB nanomicelles; Supplementary Figure S2: Effects of Cer and CDDP on cell response; Supplementary Figure S3: Effects of treatments on body weights of mice bearing tumors. Supplementa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d164438088dc67cbe65b77cc5abb3fd3
https://doi.org/10.1158/1535-7163.22506138
https://doi.org/10.1158/1535-7163.22506138
Autor:
Yong-Yu Liu, Ronald A. Hill, Sami Nazzal, Xin Gu, Salman B. Hosain, Mohammad B. Uddin, Kartik R. Roy, Zhijun Liu, Sachin K. Khiste
Ceramide (Cer) is an active cellular sphingolipid that can induce apoptosis or proliferation-arrest of cancer cells. Nanoparticle-based delivery offers an effective approach for overcoming bioavailability and biopharmaceutics issues attributable to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b16d16d749b7e8f93088a8db4fc9e8c
https://doi.org/10.1158/1535-7163.c.6538305.v1
https://doi.org/10.1158/1535-7163.c.6538305.v1
Autor:
Sagor C Roy, Ronald A. Hill, Mohammad Burhan Uddin, Jean Christopher Chamcheu, Hua Lu, Y Li, Kartik R. Roy, John Marshall, Yong-Yu Liu
Publikováno v:
FASEB BioAdvances, Vol 2, Iss 11, Pp 653-667 (2020)
FASEB BioAdvances
FASEB BioAdvances
Glucosylceramide synthase (GCS) is a key enzyme catalyzing ceramide glycosylation to generate glucosylceramide (GlcCer), which in turn serves as the precursor for cells to produce glycosphingolipids (GSLs). In cell membranes, GSLs serve as essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51fb1ee804155b90558cb8fa976bce7
https://doaj.org/article/973d41d7eb66424a8dba340670718eb5
https://doaj.org/article/973d41d7eb66424a8dba340670718eb5
Autor:
Sachin K. Khiste, Mohammad Burhan Uddin, Ronald A. Hill, Sami Nazzal, Zhijun Liu, Xin Gu, Salman B. Hosain, Kartik R. Roy, Yong-Yu Liu
Publikováno v:
Mol Cancer Ther
Ceramide (Cer) is an active cellular sphingolipid that can induce apoptosis or proliferation-arrest of cancer cells. Nanoparticle-based delivery offers an effective approach for overcoming bioavailability and biopharmaceutics issues attributable to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae88a166a6615dc88a9edc3c198599b5
https://doi.org/10.1158/1535-7163.mct-19-0366
https://doi.org/10.1158/1535-7163.mct-19-0366
Autor:
Sachin K. Khiste, Seetharama D. Jois, Kartik R. Roy, Mohammad Burhan Uddin, Ronald A. Hill, Yong-Yu Liu, Alan J. Tackett, Yunfeng Zhao, Salman B. Hosain
Publikováno v:
Biochemical Pharmacology. 160:134-145
Mutant p53 proteins that promote cancer cell invasive growth, metastasis and drug resistance emerge as therapeutic targets. Previously, we reported that suppression of ceramide glycosylation restored wild-type p53 protein and tumor suppressing functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43c3e01bc96ffb133fc6c84c8e2fe334
https://doi.org/10.1016/j.bcp.2018.12.014
https://doi.org/10.1016/j.bcp.2018.12.014
Autor:
Mohammad B. Uddin, Kartik R. Roy, Ronald A. Hill, Sagor C. Roy, Xin Gu, Li Li, Qian-Jin Zhang, Zongbing You, Yong-Yu Liu
Publikováno v:
Experimental Cell Research. 417:113210
Cancer cells acquire immunoediting ability to evade immune surveillance and thus escape eradication. It is widely known that mutant proteins encoded from tumor suppressor TP53 exhibit gain-of-function in cancer cells, thereby promoting progression; h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c74e33d431b4ad6529dd768d366ef77
https://doi.org/10.1016/j.yexcr.2022.113210
https://doi.org/10.1016/j.yexcr.2022.113210
Autor:
Jianzhong, Chen, Sachin K, Khiste, Xiaomei, Fu, Kartik R, Roy, Yixuan, Dong, Jian, Zhang, Mei, Liu, Yong-Yu, Liu, Zhijun, Liu
Publikováno v:
Prostaglandinsother lipid mediators. 146
Although C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a1b822fa0f97f3abad44debbb7299dda
https://pubmed.ncbi.nlm.nih.gov/31841664
https://pubmed.ncbi.nlm.nih.gov/31841664