Zobrazeno 1 - 10 of 48 pro vyhledávání: '"Karthinathan Thangavelu"'
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Akademický článek
Subcutaneous Sarilumab in Patients With Rheumatoid Arthritis who Previously Received Subcutaneous Sarilumab or Intravenous Tocilizumab: An Open‐Label Extension of a Randomized Clinical Trial
Autor: Paul Emery, Hubert vanHoogstraten, Karthinathan Thangavelu, Erin Mangan, Gregory St John, Patrick Verschueren
Publikováno v: ACR Open Rheumatology, Vol 2, Iss 11, Pp 672-680 (2020)
Objective This post hoc analysis evaluated the safety and efficacy of open‐label sarilumab in patients with rheumatoid arthritis (RA) who completed the phase III double‐blind ASCERTAIN study (NCT01768572) and switched from intravenous (IV) tocili
Externí odkaz: https://doaj.org/article/36ecd7f5989b48a6bdbf4ee24603be27
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2
Akademický článek
Interleukin-6 receptor blockade or TNFα inhibition for reducing glycaemia in patients with RA and diabetes: post hoc analyses of three randomised, controlled trials
Autor: Mark C. Genovese, Gerd R. Burmester, Owen Hagino, Karthinathan Thangavelu, Melitza Iglesias-Rodriguez, Gregory St John, Miguel A. González-Gay, Thomas Mandrup-Poulsen, Roy Fleischmann
Publikováno v: Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-12 (2020)
Abstract Background Diabetes is common in patients with rheumatoid arthritis (RA). Interleukin (IL)-6 is implicated in both the pathogenesis of RA and in glucose homeostasis; this post hoc analysis investigated the effects of IL-6 receptor vs. tumour
Externí odkaz: https://doaj.org/article/3a969e68370045a191ca64cd450c21ad
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4
Interleukin-6 receptor blockade or TNFα inhibition for reducing glycaemia in patients with RA and diabetes: post hoc analyses of three randomised, controlled trials
Autor: Melitza Iglesias-Rodriguez, Miguel A. González-Gay, Mark C. Genovese, Gerd R Burmester, Thomas Mandrup-Poulsen, Roy Fleischmann, Karthinathan Thangavelu, Gregory St John, Owen Hagino
Publikováno v: Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-12 (2020)
Arthritis Research & Therapy (2020) 22:206
UCrea Repositorio Abierto de la Universidad de Cantabria
instname
Arthritis Research & Therapy
Genovese, M C, Burmester, G R, Hagino, O, Thangavelu, K, Iglesias-Rodriguez, M, John, G S, Gonzalez-Gay, M A, Mandrup-Poulsen, T & Fleischmann, R 2020, ' Interleukin-6 receptor blockade or TNF alpha inhibition for reducing glycaemia in patients with RA and diabetes : post hoc analyses of three randomised, controlled trials ', Arthritis Research & Therapy, vol. 22, no. 1, 206 . https://doi.org/10.1186/s13075-020-02229-5
Background Diabetes is common in patients with rheumatoid arthritis (RA). Interleukin (IL)-6 is implicated in both the pathogenesis of RA and in glucose homeostasis; this post hoc analysis investigated the effects of IL-6 receptor vs. tumour necrosis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5688cf73bcc5ab387b1d94824c66e760
http://link.springer.com/article/10.1186/s13075-020-02229-5
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5
Dupilumab Efficacy in Patients with Uncontrolled, Moderate-to-Severe Allergic Asthma
Autor: Mario Castro, Ariel Teper, Siddhesh Kamat, Sivan Harel, Marcella Ruddy, Thomas G. O'Riordan, Jaman Maroni, Nicola A. Hanania, Paul Rowe, Bradley E. Chipps, Megan S. Rice, Alexandre Jagerschmidt, Yufang Lu, Nikhil Amin, Ian D. Pavord, Santiago Quirce, Asif Khan, Karthinathan Thangavelu, Sally E. Wenzel, Jonathan Corren, Neil M.H. Graham, Gianluca Pirozzi
Publikováno v: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
BACKGROUND: Dupilumab blocks the shared receptor component for IL-4 and IL-13, key drivers of type 2 inflammation, including IgE-mediated allergic inflammation in asthma. In the LIBERTY ASTHMA QUEST (NCT02414854) study, dupilumab reduced severe asthm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e31865cadddcc6df143a15abed9bf9c
https://doi.org/10.1016/j.jaip.2019.08.050
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7
Comparative effectiveness of teriflunomide and dimethyl fumarate in patients with relapsing forms of MS in the retrospective real-world Teri-RADAR study
Autor: Bhupendra O. Khatri, Matt Mandel, Kiren Kresa-Reahl, Chakkarin Burudpakdee, Keith R. Edwards, Jeffrey Chavin, Robert Zivadinov, Bianca Weinstock-Guttman, Karthinathan Thangavelu, Stanley Cohan, Michael G. Dwyer, Niels Bergsland
Publikováno v: Journal of Comparative Effectiveness Research. 8:305-316
Aim: Head-to-head clinical trials of teriflunomide (TFM) versus dimethyl fumarate (DMF) have not been conducted. Objectives: To compare the real-world effectiveness of TFM versus DMF. Methods: Anonymized data were collected from patients with relapsi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdcf46488f3e5b5274378662eb4287a8
https://doi.org/10.2217/cer-2018-0135
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8
Immune thrombocytopenia in alemtuzumab-treated MS patients: Incidence, detection, and management
Autor: Adam Cuker, Christopher LaGanke, Congor Nadj, Alexandre Guerreiro, Sven G. Meuth, Brian Steingo, Bart Van Wijmeersch, Karthinathan Thangavelu, Mark A Agius, Krzysztof Selmaj, Timothy Thoits, Claudio E Rodriguez, David Margolin, Ann Jannsens, Tjalf Ziemssen, Darren P Baker, Ann D Bass
Publikováno v: Multiple Sclerosis (Houndmills, Basingstoke, England)
Background: Alemtuzumab is a highly effective therapy for relapsing-remitting multiple sclerosis (RRMS), and immune thrombocytopenia (ITP) has been identified as a risk. Objective: To examine ITP incidence, treatment, and outcomes during the clinical
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616f13d1885442ebeb44b0378940ee72
https://doi.org/10.1177/1352458518816612
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9
A Pilot Open-label Study of Aldose Reductase Inhibition with AT-001 (caficrestat) in Patients Hospitalized for COVID-19 Infection: Results from a Registry-based Matched-control Analysis
Autor: Stuart D. Katz, Ann Marie Schmidt, Karthinathan Thangavelu, Riccardo Perfetti, Ravichandran Ramasamy, Glenn I. Fishman, Juan Gaztanaga, Shoshana Schendelman
Publikováno v: American Heart Journal
Diabetes & Metabolic Syndrome
Background Cardiometabolic disease may confer increased risk of adverse outcomes in COVID-19 patients by activation of the aldose reductase pathway, a trigger of the inflammatory cascade. We hypothesized that aldose reductase inhibition with AT-001 (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef61430ac8d055ead07476964bdd37fe
https://doi.org/10.1016/j.ahj.2021.10.022
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10
Mapping analysis to predict SF-6D utilities from health outcomes in people with focal epilepsy
Autor: India Flint, Jasmina Medjedovic, Ewa Drogon O’Flaherty, Elena Alvarez-Baron, Karthinathan Thangavelu, Natasa Savic, Aurelie Meunier, Louise Longworth
Publikováno v: The European journal of health economics : HEPAC : health economics in prevention and care.
Focal-onset seizures (FOS) are commonly experienced by people with epilepsy and have a significant impact on quality of life (QoL). This study aimed to develop a mapping algorithm to predict SF-6D values in adults with FOS for use in economic evaluat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ca46d4ffbe528b7a7b17e9d191719b
https://pubmed.ncbi.nlm.nih.gov/36260149
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