Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Karthikeyan Diraviyam"'
Autor:
Kristen M Skillman, Karthikeyan Diraviyam, Asis Khan, Keliang Tang, David Sept, L David Sibley
Publikováno v:
PLoS Pathogens, Vol 7, Iss 10, p e1002280 (2011)
Apicomplexan parasites rely on a novel form of actin-based motility called gliding, which depends on parasite actin polymerization, to migrate through their hosts and invade cells. However, parasite actins are divergent both in sequence and function
Externí odkaz:
https://doaj.org/article/9bb1fe46a1f7486eae70f4cba7a02272
Publikováno v:
Journal of Molecular Biology. 395:544-557
The conformational dynamics of filamentous actin (F-actin) is essential for the regulation and functions of cellular actin networks. The main contribution to F-actin dynamics and its multiple conformational states arises from the mobility and flexibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a68b48bbcef345032d30cffa49ad7e3
https://doi.org/10.1016/j.jmb.2009.11.001
https://doi.org/10.1016/j.jmb.2009.11.001
Publikováno v:
Biophysical Journal. 95(8):3827-3839
Strongly inwardly rectifying potassium channels are blocked by intracellular polyamines with a uniquely steep voltage dependence. An understanding of the fundamental details underlying the voltage dependence of polyamine block requires a constrained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c6460d9616d0df03dde9ebd5539176
Autor:
Karthikeyan Diraviyam, Diana Murray
Publikováno v:
Biochemistry. 45:2584-2598
Secreted phospholipases A2 (sPLA2's) are enzymes that hydrolyze glycerophospholipids at the sn-2 position, which leads to the production of lipid mediators of many cellular processes. These interfacial enzymes are regulated by their lipid specificity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2691187511f77013bc1e5b108c1409eb
https://doi.org/10.1021/bi051901t
https://doi.org/10.1021/bi051901t
Autor:
Wonhwa Cho, Robert V. Stahelin, Karol S. Bruzik, Diana Murray, Karthikeyan Diraviyam, Fei Long
Publikováno v:
Journal of Biological Chemistry. 277:26379-26388
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. To elucidate the mechanism by which the FYVE domain interacts with PtdIns(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ccc672bed009d0f76abd5e06233f26a
https://doi.org/10.1074/jbc.m201106200
https://doi.org/10.1074/jbc.m201106200
Autor:
Takaoki Koyanagi, Young Hun Kim, Michael Mayer, David Sept, Karthikeyan Diraviyam, Thomas Schroeder, Jerry Yang, Olivia M. Eggenberger, Geoffray Leriche
Publikováno v:
ResearcherID
Many archaea are able to withstand extremes of temperature, pressure, pH and/or levels of salt. One unique feature of these extremophiles that gives them this capability is that their membranes are made from covalently linked, tetraether lipids that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90bae55df97a976a8c78054641e3a60e
https://doi.org/10.1016/j.bpj.2016.11.2082
https://doi.org/10.1016/j.bpj.2016.11.2082
Publikováno v:
Journal of Natural Products
Apicomplexan parasites such as Toxoplasma gondii rely on actin-based motility to cross biological barriers and invade host cells. Key structural and biochemical differences in host and parasite actins make this an attractive target for small-molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a4ed49d8664e427c5e351bf0c71560
https://pubmed.ncbi.nlm.nih.gov/24020843
https://pubmed.ncbi.nlm.nih.gov/24020843
The HER2 receptor tyrosine kinase is a driver oncogene in many human cancers, including breast and gastric cancer. Under physiologic levels of expression, HER2 heterodimerizes with other members of the EGF receptor/HER/ErbB family, and the HER2-HER3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760ea2002bf3ad142c6a6450731ec99c
https://europepmc.org/articles/PMC3757188/
https://europepmc.org/articles/PMC3757188/
Publikováno v:
AIP Conference Proceedings.
Biomolecular simulations typically produce data in the form of a trajectory where the structure and dynamics are captured as a function of time. These data typically have inherent temporal correlations, however the many of the analysis methods we use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::071b19b024408c56dc6961d15ba952c0
https://doi.org/10.1063/1.4730657
https://doi.org/10.1063/1.4730657
Autor:
Asis Khan, L. David Sibley, Keliang Tang, Kristen M. Skillman, David Sept, Karthikeyan Diraviyam
Publikováno v:
PLoS Pathogens, Vol 7, Iss 10, p e1002280 (2011)
PLoS Pathogens
PLoS Pathogens
Apicomplexan parasites rely on a novel form of actin-based motility called gliding, which depends on parasite actin polymerization, to migrate through their hosts and invade cells. However, parasite actins are divergent both in sequence and function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7fdc9116ae93204ddda20d206d8fed8
http://europepmc.org/articles/PMC3188518?pdf=render
http://europepmc.org/articles/PMC3188518?pdf=render