Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Karthik Shekhar"'
Autor:
Lauren K. Wareham, Shane A. Liddelow, Sally Temple, Larry I. Benowitz, Adriana Di Polo, Cheryl Wellington, Jeffrey L. Goldberg, Zhigang He, Xin Duan, Guojun Bu, Albert A. Davis, Karthik Shekhar, Anna La Torre, David C. Chan, M. Valeria Canto-Soler, John G. Flanagan, Preeti Subramanian, Sharyn Rossi, Thomas Brunner, Diane E. Bovenkamp, David J. Calkins
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-29 (2022)
Abstract Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address these mechanisms and discuss em
Externí odkaz:
https://doaj.org/article/c304792ddb214075a9d068c15e1e5d12
Publikováno v:
eLife, Vol 11 (2022)
The genesis of broad neuronal classes from multipotential neural progenitor cells has been extensively studied, but less is known about the diversification of a single neuronal class into multiple types. We used single-cell RNA-seq to study how newly
Externí odkaz:
https://doaj.org/article/a10efda4c53b4e888c1b7ce1e26c7c78
Autor:
Christopher A Werley, Miao-Ping Chien, Jellert Gaublomme, Karthik Shekhar, Vincent Butty, B Alexander Yi, Joel M Kralj, William Bloxham, Laurie A Boyer, Aviv Regev, Adam E Cohen
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172671 (2017)
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a promising platform for cardiac studies in vitro, and possibly for tissue repair in humans. However, hiPSC-CM cells tend to retain morphology, metabolism, patterns of gene exp
Externí odkaz:
https://doaj.org/article/23e59abed85b48d2860c1c438a159503
Autor:
Karthik Shekhar
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, February 2015.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 301-318).
Developing successful prophylactic and
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 301-318).
Developing successful prophylactic and
Externí odkaz:
http://hdl.handle.net/1721.1/98339
Autor:
Joshua Hahn, Aboozar Monavarfeshani, Mu Qiao, Allison Kao, Yvonne Kölsch, Ayush Kumar, Vincent P Kunze, Ashley M. Rasys, Rose Richardson, Herwig Baier, Robert J. Lucas, Wei Li, Markus Meister, Joshua T. Trachtenberg, Wenjun Yan, Yi-Rong Peng, Joshua R. Sanes, Karthik Shekhar
The basic plan of the retina is conserved across vertebrates, yet species differ profoundly in their visual needs (Baden et al., 2020). One might expect that retinal cell types evolved to accommodate these varied needs, but this has not been systemat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e292aa86660bfaac7497790821a1b790
https://doi.org/10.1101/2023.04.07.536039
https://doi.org/10.1101/2023.04.07.536039
Autor:
Inbal Benhar, Jiarui Ding, Wenjun Yan, Irene E. Whitney, Anne Jacobi, Malika Sud, Grace Burgin, Karthik Shekhar, Nicholas M. Tran, Chen Wang, Zhigang He, Joshua R. Sanes, Aviv Regev
Publikováno v:
Nature immunology, vol 24, iss 4
Non-neuronal cells are key to the complex cellular interplay that follows central nervous system insult. To understand this interplay, we generated a single-cell atlas of immune, glial and retinal pigment epithelial cells from adult mouse retina befo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8a25e32c4f97c601714b4199c9b577
https://escholarship.org/uc/item/9zj7f36w
https://escholarship.org/uc/item/9zj7f36w
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630112
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e585d5ea5620609aa781f1aaab79734
https://doi.org/10.1007/978-1-0716-3012-9_2
https://doi.org/10.1007/978-1-0716-3012-9_2
Autor:
Irene E. Whitney, Salwan Butrus, Michael A. Dyer, Fred Rieke, Joshua R. Sanes, Karthik Shekhar
The development and connectivity of retinal ganglion cells (RGCs), the retina’s sole output neurons, are patterned by activity-independent transcriptional programs and activity-dependent remodeling. To inventory the molecular correlates of these in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61eefb6beb0abb424df6d51f49b8c14
https://doi.org/10.1101/2022.04.20.488897
https://doi.org/10.1101/2022.04.20.488897
Autor:
Dejan Juric, Yi-Rong Peng, Joshua R. Sanes, Alexi McAdams, Aviv Regev, Wenjun Yan, Karthik Shekhar, Tavé van Zyl
Publikováno v:
Proc Natl Acad Sci U S A
Increased intraocular pressure (IOP) represents a major risk factor for glaucoma, a prevalent eye disease characterized by death of retinal ganglion cells; lowering IOP is the only proven treatment strategy to delay disease progression. The main dete