Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Karthik S. Iyer"'
Publikováno v:
JACS Au, Vol 4, Iss 2, Pp 680-689 (2024)
Externí odkaz:
https://doaj.org/article/95ff415ee5714db1a6fd1de5f23529de
Autor:
Joseph R. A. Kincaid, Juan C. Caravez, Karthik S. Iyer, Rahul D. Kavthe, Nico Fleck, Donald H. Aue, Bruce H. Lipshutz
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-7 (2022)
The antiviral drug nirmatrelvir is the active ingredient in Paxlovid, a SARS-CoV-2 Mpro inhibitor developed by Pfizer, however, its synthetic procedure faces limitations for meeting urgent demand. Here, the authors optimize the key synthetic steps an
Externí odkaz:
https://doaj.org/article/c6511b695b1d4b759ca58f72f163042a
Publikováno v:
Green Chemistry. 25:2663-2671
Facile reductions of carboxylic acids to aldehydes or alcohols can be effected under mild conditions upon initial conversion to their corresponding S-2-pyridyl thioesters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17978458a10bfd5b2a89117f3b6e5508
https://doi.org/10.1039/d3gc00517h
https://doi.org/10.1039/d3gc00517h
Publikováno v:
Organic Letters. 24:9049-9053
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b5b7282c9984616743f3f2b247ee53f
https://doi.org/10.1021/acs.orglett.2c03683
https://doi.org/10.1021/acs.orglett.2c03683
Publikováno v:
Green Chemistry. 24:3640-3643
A green sequence to lapatinib has been developed as a representative example showcasing the technologies that are available today for applications to targets in the fine chemicals industry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20b2bc5b7e78cc35e2884e70f7f0fd74
https://doi.org/10.1039/d2gc00598k
https://doi.org/10.1039/d2gc00598k
Publikováno v:
Chemical science, vol 14, iss 23
A 6-step synthesis of the antimalarial drug candidate MMV688533 is reported. Key transformations carried out under aqueous micellar conditions include two Sonogashira couplings and amide bond formation. Compared with the first-generation manufacturin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ab3bc2a2234cc0bdabdf287795062b
https://doi.org/10.1039/d3sc01699d
https://doi.org/10.1039/d3sc01699d
Autor:
Bruce H. Lipshutz, Xiaohan Li, David K. Leahy, Ruchita R. Thakore, Karthik S. Iyer, J. Daniel Bailey
Publikováno v:
Organic Letters. 23:7205-7208
Highly valued products resulting from reductive aminations utilizing shelf-stable bisulfite addition compounds of aldehydes can be made under aqueous micellar catalysis conditions. Readily available α-picolineborane serves as the stoichiometric hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269040d8b0599fb3490c90e37b081674
https://doi.org/10.1021/acs.orglett.1c02604
https://doi.org/10.1021/acs.orglett.1c02604
Autor:
Joseph R. A. Kincaid, Juan C. Caravez, Karthik S. Iyer, Rahul D. Kavthe, Nico Fleck, Bruce H. Lipshutz
A convergent route to the antiviral drug nirmatrelvir is described, arriving at the targeted drug in 45% overall yield with no loss of stereointegrity. Critical amide bond-forming steps utilize green technology that avoids traditional peptide couplin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::586581a82afe35d4d8cb715289d825ac
https://doi.org/10.26434/chemrxiv-2022-hmdd4
https://doi.org/10.26434/chemrxiv-2022-hmdd4
Publikováno v:
Current Opinion in Green and Sustainable Chemistry. 38:100686
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da2931ea166136d5a3a9e140b156f620
https://doi.org/10.1016/j.cogsc.2022.100686
https://doi.org/10.1016/j.cogsc.2022.100686
Publikováno v:
Current Opinion in Green and Sustainable Chemistry. 31:100493
Reactions are discussed that lead to the valuable amine functional group in aromatics and heteroaromatics, carried out under sustainable conditions in water enabled by micellar catalysis. These new technologies are general and have been successfully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d164f6443bc77211e371c97caf937c3
https://doi.org/10.1016/j.cogsc.2021.100493
https://doi.org/10.1016/j.cogsc.2021.100493