Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Karthik S Prabhakara"'
Autor:
Henry W Caplan, Karthik S Prabhakara, Naama E Toledano Furman, Soheil Zorofchian, Cecilia Martin, Hasen Xue, Scott D Olson, Charles S Cox
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251601 (2021)
Traumatic brain injury (TBI) causes both physical disruption of the blood brain barrier (BBB) and altered immune responses that can lead to significant secondary brain injury and chronic inflammation within the central nervous system (CNS). Cell ther
Externí odkaz:
https://doaj.org/article/16a3ed46c4164efd89a59ec139a4fb13
Autor:
Katherine A Ruppert, Karthik S Prabhakara, Naama E Toledano-Furman, Sanjna Udtha, Austin Q Arceneaux, Hyeonggeun Park, An Dao, Charles S Cox, Scott D Olson
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233263 (2020)
In the U.S., approximately 1.7 million people suffer traumatic brain injury each year, with many enduring long-term consequences and significant medical and rehabilitation costs. The primary injury causes physical damage to neurons, glia, fiber tract
Externí odkaz:
https://doaj.org/article/eb0bfd7ea825487d97b1f735d695a7c3
Autor:
Karthik S. Prabhakara, Kavya Ganapathy, Kazi N. Islam, Hiran M. Thyagarajan, Kirti K. Tiwari, Ramya L. Parimi, Mohammad B. Rashid
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 388 (2024)
Peroxidative damage to human spermatozoa has been shown to be the primary cause of male infertility. The possible role of nitric oxide (NO) in affecting sperm motility, capacitation, and acrosome reaction has been reported, too. The overproduction of
Externí odkaz:
https://doaj.org/article/27777897766e4bd3984897704cddb8aa
Autor:
Assaf Gottlieb, Naama Toledano-Furman, Karthik S. Prabhakara, Akshita Kumar, Henry W. Caplan, Supinder Bedi, Charles S. Cox, Scott D. Olson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Traumatic brain injury (TBI) results in a cascade of cellular responses, which produce neuroinflammation, partly due to the activation of microglia. Accurate identification of microglial populations is key to understanding therapeutic approa
Externí odkaz:
https://doaj.org/article/23b474813678411bab4e7276522ecb56
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Mesenchymal stromal cells (MSC) undergo functional maturation upon their migration from bone marrow and introduction to a site of injury. This inflammatory licensing leads to heightened immune regulation via cell-to-cell interaction and the secretion
Externí odkaz:
https://doaj.org/article/edf0cec9d5a84effadfce7f3b0d9adc6
Autor:
Henry Caplan, Scott D. Olson, Akshita Kumar, Mitchell George, Karthik S. Prabhakara, Pamela Wenzel, Supinder Bedi, Naama E. Toledano-Furman, Fabio Triolo, Julian Kamhieh-Milz, Guido Moll, Charles S. Cox
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
For several decades, multipotent mesenchymal stromal cells (MSCs) have been extensively studied for their therapeutic potential across a wide range of diseases. In the preclinical setting, MSCs demonstrate consistent ability to promote tissue healing
Externí odkaz:
https://doaj.org/article/7dc7bc6adfe844da8ceba9381f2461fe
Autor:
Naama E. Toledano Furman, Karthik S. Prabhakara, Henry W. Caplan, Charles S. Cox, Hasen Xue, Cecilia Martin, Akshita Kumar, Soheil Zorofchian, Scott D. Olson
Publikováno v:
Stem Cells
The inflammatory response after traumatic brain injury (TBI) can lead to significant secondary brain injury and chronic inflammation within the central nervous system. Cell therapies, including mesenchymal stromal cells (MSC), have led to improvement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572ad9fa5fa08c83008e5f4ae4be1ace
https://doi.org/10.1002/stem.3320
https://doi.org/10.1002/stem.3320
Autor:
Assaf Gottlieb, Scott D. Olson, Naama E. Toledano Furman, Supinder S. Bedi, Karthik S. Prabhakara, Henry W. Caplan, Charles S. Cox, Katherine A. Ruppert, Amit K. Srivastava
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Traumatic brain injury (TBI) results in a cascade of cellular responses, which produce neuroinflammation, partly due to microglial activation. Transforming from surveying to primed phenotypes, microglia undergo considerable molecular changes. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21cd1240094dfae0036a718f1a7d706b
http://link.springer.com/article/10.1038/s41598-020-68770-0
http://link.springer.com/article/10.1038/s41598-020-68770-0
Autor:
Akshita Kumar, Karthik S. Prabhakara, Henry W. Caplan, Andrea S. Bordt, Cecilia Martin, Naama E. Toledano-Furman, Louis A. Carrillo, Charles S. Cox, Scott D. Olson, Nicolas F. Moreno
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 8, Pp 903-916 (2020)
Stem Cells Translational Medicine
Stem Cells Translational Medicine
Traumatic brain injury (TBI) causes a profound inflammatory response within the central nervous system and peripheral immune system, which contributes to secondary brain injury and further morbidity and mortality. Preclinical investigations have demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1b564f507366ee878df82c1bde1450
https://doi.org/10.1002/sctm.19-0444
https://doi.org/10.1002/sctm.19-0444
Autor:
Charles E. Wade, Mitchell J. George, Karthik S. Prabhakara, Charles S. Cox, Naama E. Toledano-Furman, Bryan A. Cotton, Brijesh S. Gill, Andrew P. Cap, Scott D. Olson
Publikováno v:
Stem Cells Translational Medicine
Stem Cells Translational Medicine, Vol 9, Iss 4, Pp 491-498 (2020)
Stem Cells Translational Medicine, Vol 9, Iss 4, Pp 491-498 (2020)
Clinical trials in trauma populations are exploring the use of clinical cellular therapeutics (CCTs) like human mesenchymal stromal cells (MSC) and mononuclear cells (MNC). Recent studies demonstrate a procoagulant effect of these CCTs related to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc289a04a65027d5d96de4b27fa36a2a
https://doi.org/10.1002/sctm.19-0206
https://doi.org/10.1002/sctm.19-0206