Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Karthik R. Ramanathan"'
Thalamic nucleus reuniens coordinates prefrontal-hippocampal synchrony to suppress extinguished fear
Autor:
Michael S. Totty, Tuğçe Tuna, Karthik R. Ramanathan, Jingji Jin, Shaun E. Peters, Stephen Maren
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Traumatic events result in vivid and enduring fear memories. Suppressing the retrieval of these memories is central to behavioral therapies for pathological fear. The medial prefrontal cortex (mPFC) and hippocampus (HPC) have been implicated
Externí odkaz:
https://doaj.org/article/fc108b4d04a5459f8f452d0bc63b5c6f
Autor:
Michael S. Totty, Naomi Warren, Isabella Huddleston, Karthik R. Ramanathan, Reed L. Ressler, Cecily R. Oleksiak, Stephen Maren
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Environmental contexts can inform animals of potential threats, though it is currently unknown how context biases the selection of defensive behavior. Here we investigated context-dependent flight responses with a Pavlovian serial-compound s
Externí odkaz:
https://doaj.org/article/6144c436f3634dfebf54850fad3c3297
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Previous work has shown that the thalamic nucleus reuniens (RE) is involved in memory and emotion. Here the authors report that the RE and its inputs from the medial prefrontal cortex are indispensable for the top-down inhibition of fear memories aft
Externí odkaz:
https://doaj.org/article/2c05d4890864491b86de7d7904a2ad25
Publikováno v:
Learning & Memory. 29:216-222
Recent data reveal that the thalamic nucleus reuniens (RE) has a critical role in the extinction of conditioned fear. Muscimol (MUS) infusions into the RE impair within-session extinction of conditioned freezing and result in poor long-term extinctio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197eb4ac9a0f4a6439061cd9ee55b151
https://doi.org/10.1101/lm.053611.122
https://doi.org/10.1101/lm.053611.122
Thalamic nucleus reuniens coordinates prefrontal-hippocampal synchrony to suppress extinguished fear
Traumatic events result in vivid and enduring fear memories. Suppressing the retrieval of these memories is central to behavioral therapies for pathological fear. The medial prefrontal cortex (mPFC) and hippocampus (HPC) have been implicated in retri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::165ddffcb1d49f7a8edc0c7006942248
https://doi.org/10.1101/2022.11.11.516165
https://doi.org/10.1101/2022.11.11.516165
Publikováno v:
Nature Neuroscience. 24:677-684
Reconsolidation may be a viable therapeutic target to inhibit pathological fear memories. In the clinic, incidental or imaginal reminders are used for safe retrieval of traumatic memories of experiences that occurred elsewhere. However, it is unknown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c85a30d7d7f1e8571fd299ed871136a
https://doi.org/10.1038/s41593-021-00825-5
https://doi.org/10.1038/s41593-021-00825-5
Autor:
Stephen Maren, Justin M. Moscarello, Cecily R. Oleksiak, Karthik R. Ramanathan, Sarah J. Perry, Olivia W. Miles
Publikováno v:
Neurobiol Learn Mem
Considerable work indicates that instrumental responding is context-dependent, but the neural mechanisms underlying this phenomenon are poorly understood. Given the important role for the hippocampal formation in contextual processing, we hypothesize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cdf45e27fdbb8b8f5aedea143aa609b
https://doi.org/10.1101/2021.02.04.429792
https://doi.org/10.1101/2021.02.04.429792
Publikováno v:
Nature neuroscience. 24(5)
Reconsolidation may be a viable therapeutic target to inhibit pathological fear memories. In the clinic, incidental or imaginal reminders are used for safe retrieval of traumatic memories of experiences that occurred elsewhere. However, it is unknown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::21fb9948d672ec22dbcb8549ca9bc9da
https://pubmed.ncbi.nlm.nih.gov/33795884
https://pubmed.ncbi.nlm.nih.gov/33795884
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
The thalamic nucleus reuniens (RE) receives dense projections from the medial prefrontal cortex (mPFC), interconnects the mPFC and hippocampus, and may serve a pivotal role in regulating emotional learning and memory. Here we show that the RE and its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1afae90a3abadddeb235a4235ebed49
http://link.springer.com/article/10.1038/s41467-018-06970-z
http://link.springer.com/article/10.1038/s41467-018-06970-z
Autor:
Stephen Maren, Karthik R. Ramanathan
Publikováno v:
Behav Brain Res
Learning and remembering the context in which events occur requires interactions between the hippocampus (HPC) and medial prefrontal cortex (mPFC). The nucleus reuniens (RE) is a ventral midline thalamic nucleus that coordinates activity in the mPFC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c1462dce7425ddecc1e03f79864028
https://pubmed.ncbi.nlm.nih.gov/31351844
https://pubmed.ncbi.nlm.nih.gov/31351844