Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Karthik R. Padmanabhan"'
Autor:
Nicole K. Patel, Johanna H. Nunez, Michael Sorkin, Simone Marini, Chase A. Pagani, Amy L. Strong, Charles D. Hwang, Shuli Li, Karthik R. Padmanabhan, Ravi Kumar, Alec C. Bancroft, Joey A. Greenstein, Reagan Nelson, Husain A. Rasheed, Nicholas Livingston, Kaetlin Vasquez, Amanda K. Huber, Benjamin Levi
Publikováno v:
JCI Insight, Vol 7, Iss 20 (2022)
Transforming growth factor–β1 (TGF-β1) plays a central role in normal and aberrant wound healing, but the precise mechanism in the local environment remains elusive. Here, using a mouse model of aberrant wound healing resulting in heterotopic oss
Externí odkaz:
https://doaj.org/article/cf7ee5b870864d58ad1c8f000e54e03f
Autor:
Zachary M. Laubach, Julia R. Greenberg, Julie W. Turner, Tracy M. Montgomery, Malit O. Pioon, Maggie A. Sawdy, Laura Smale, Raymond G. Cavalcante, Karthik R. Padmanabhan, Claudia Lalancette, Bridgett vonHoldt, Christopher D. Faulk, Dana C. Dolinoy, Kay E. Holekamp, Wei Perng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Early social experience can alter epigenetic patterns and stress responses later in life. A study on wild spotted hyenas finds that maternal care and social connections after leaving the den influence DNA methylation and contribute to a developmental
Externí odkaz:
https://doaj.org/article/26a7708842bf456a9e9e486a8e5289da
Autor:
Daniel L. Matera, Brendon M. Baker, Yi Tang, Amy L. Strong, Chase A. Pagani, Stephen J. Weiss, Amanda K. Huber, Shuli Li, Mohamed Said, Michael T. Longaker, Reagan Nelson, Ginny Ching Yun Hsu, Benjamin Levi, Simone Marini, Noelle D. Visser, Joseph A. Greenstein, Karthik R. Padmanabhan, Andrea A. Poli, Charles Hwang, Aaron W. James, Nicole Patel
Publikováno v:
J Clin Invest
Cells sense the extracellular environment and mechanical stimuli and translate these signals into intracellular responses through mechanotransduction, which alters cell maintenance, proliferation, and differentiation. Here we use a mouse model of tra
Autor:
Yashar S. Niknafs, Monica Palande, Karthik R. Padmanabhan, Matthew K. Iyer, Gilbert S. Omenn, Tingting Qin, Anjan K. Saha, Tara Tang, Maureen A. Sartor, Brian Qian, Scott D. Gitlin, David M. Markovitz, Elizabeth A. Ward, Rafael Contreras-Galindo, Arul M. Chinnaiyan, Javed Siddiqui, Claire L. Wang, Scott A. Tomlins
Publikováno v:
The Journal of Biological Chemistry
Overexpression of centromeric proteins has been identified in a number of human malignancies, but the functional and mechanistic contributions of these proteins to disease progression have not been characterized. The centromeric histone H3 variant ce
Autor:
Wei Perng, Laura Smale, Claudia Lalancette, Maggie A. Sawdy, Malit O. Pioon, Karthik R. Padmanabhan, Tracy M. Montgomery, Zachary M. Laubach, Julie W. Turner, Christopher Faulk, Bridgett M. vonHoldt, Kay E. Holekamp, Raymond G. Cavalcante, Julia R. Greenberg, Dana C. Dolinoy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Studies in rodents and captive primates suggest that the early-life social environment affects future phenotype, potentially through alterations to DNA methylation. Little is known of these associations in wild animals. In a wild population of spotte
Autor:
Amanda K. Huber, Benjamin Levi, Geoffrey E. Hespe, Nicole J. Edwards, Cheri X. Deng, Alisha Rhodes, Archie L. Overmann, Sarah A Walsh, Eric C. Hobson, Karthik R. Padmanabhan, Amy L. Strong, Benjamin W Hoyt, Devaveena Dey, Thomas A. Davis, Chase A. Pagani
Publikováno v:
Stem Cells Dev
Heterotopic ossification (HO) is a devastating condition in which ectopic bone forms inappropriately in soft tissues following traumatic injuries and orthopedic surgeries as a result of aberrant mesenchymal progenitor cell (MPC) differentiation. HO l
Autor:
Zachary M. Laubach, Wei Perng, Christopher Faulk, Karthik R. Padmanabhan, Tracy M. Montgomery, Laura Smale, Claudia Lalancette, Julie W. Turner, Kay E. Holekamp, Raymond G. Cavalcante, Malit O. Pioon, Bridgett M. vonHoldt, Dana C. Dolinoy, Julia R. Greenberg
In a wild population of spotted hyenas, we tested the hypothesis that maternal care during the first year of life and social connectedness during two periods of early development lead to differences in DNA methylation and fecal glucocorticoid metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e87d4ed84f2eb485cb7ecb794ddef070
https://doi.org/10.1101/2020.08.17.254805
https://doi.org/10.1101/2020.08.17.254805
Autor:
Amy L. Strong, Nicholas Livingston, Simone Marini, Reagan Nelson, Amanda K. Huber, Karen Kessel, Kaetlin Vasquez, Husain Rasheed, Benjamin Levi, Joseph A. Greenstein, Karthik R. Padmanabhan, Noelle D. Visser, Chase A. Pagani, Johanna Nunez, Nicole J. Edwards, Charles Hwang, Deneen M. Wellik, Yuxiao Sun, Yu Hao Cheng, Geoffrey E. Hespe, Nicole Patel, Pauline Yu, Jane Y. Song
Publikováno v:
Stem Cell Reports
Summary Heterotopic ossification (HO) is a form of pathological cell-fate change of mesenchymal stem/precursor cells (MSCs) that occurs following traumatic injury, limiting range of motion in extremities and causing pain. MSCs have been shown to diff