Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Karthik Narsimhan"'
Publikováno v:
ACS Central Science, Vol 2, Iss 6, Pp 424-429 (2016)
Externí odkaz:
https://doaj.org/article/cf3d5c7f2eb54f23954639addc729b05
Autor:
Christopher K. Prier, Karla Camacho Soto, Jacob H. Forstater, Nadine Kuhl, Jeffrey T. Kuethe, Wai Ling Cheung-Lee, Michael J. Di Maso, Claire M. Eberle, Shane T. Grosser, Hsing-I Ho, Erik Hoyt, Anne Maguire, Kevin M. Maloney, Amanda Makarewicz, Jonathan P. McMullen, Jeffrey C. Moore, Grant S. Murphy, Karthik Narsimhan, Weilan Pan, Nelo R. Rivera, Anumita Saha-Shah, David A. Thaisrivongs, Deeptak Verma, Adeya Wyatt, Daniel Zewge
Publikováno v:
ACS Catalysis. :7707-7714
Enzymes are capable of unique and selective transformations that can enable sustainable chemical production. While many industrial processes have been developed using free enzymes in aqueous solutions, immobilizing enzymes on a solid support can offe
Autor:
Glenn Spencer, Michael K. Wismer, Karthik Narsimhan, Lushi Tan, Cecilia Bottecchia, Jonathan P. McMullen, Yining Ji, Dan Lehnherr, Mikhail Reibarkh, Stephen M. Dalby, Like Chen, Feng Peng, Yipeng Lin, François Lévesque, Jarod Nappi
Publikováno v:
Organic Process Research & Development. 26:516-524
We report the development and scale-up of a continuous flow photochemical benzylic bromination en route to belzutifan (MK-6482), a small molecule for the treatment of renal cell carcinoma associate...
Autor:
Dan Lehnherr, Jonathan P. McMullen, François Lévesque, Stephen M. Dalby, Yining Ji, Karthik Narsimhan, Kai-Jiong Xiao, Mikhail Reibarkh, Cecilia Bottecchia
Publikováno v:
The Journal of Organic Chemistry. 87:2055-2062
A detailed mechanistic understanding of a benzylic photobromination en route to belzutifan (MK-6482, a small molecule for the treatment of renal cell carcinoma associated with von Hippel-Lindau syndrome) has been achieved using in situ LED-NMR spectr
Publikováno v:
Organic Process Research & Development. 24:2935-2940
A simple and inexpensive photoreactor with a throughput of kilograms of material per day has been developed. This achievement was enabled by using high-power Light Emitting Diodes (LEDs) to provide...
Autor:
Michael J. Di Maso, Si-Wei Zhang, Wenjun Liu, Embarek Alwedi, Alfred Y. Lee, Richard Desmond, Hong Ren, Sumei Ren, Karthik Narsimhan, Alexei Kalinin, Kevin M. Maloney, Patrick Larpent
Publikováno v:
Organic Process Research & Development. 24:2491-2497
A scalable two-pot sulfonamidation through the process has been developed for the synthesis of gefapixant citrate, a P2X3 receptor antagonist that is under investigation for the treatment of refrac...
Autor:
Eric B. Sirota, Karthik Narsimhan, Feng Peng, Mark Weisel, Alfred Y. Lee, Rebecca A. Arvary, Claire Lee, Daniel Bishara, Kevin M. Maloney, Andrew Brunskill, François Lévesque, Patrick Larpent, Michael Whittington, John R. Naber, Guy R. Humphrey, Dan Lehnherr, Si-Wei Zhang
Publikováno v:
Organic Process Research & Development. 24:2453-2461
Various synthetic routes to 2-isopropyl-4-methoxyphenol 3, the phenol core of Gefapixant citrate (MK-7264), are described, which provide better alternatives to the initial four-step supply route. T...
Autor:
Mark M. Sullivan, Karthik Narsimhan, Yuriy Román-Leshkov, Randall J. Meyer, Mircea Dincă, Pedro Serna, Kimberly T. Dinh
Publikováno v:
Journal of the American Chemical Society. 141:11641-11650
Copper-exchanged zeolites can continuously and selectively catalyze the partial oxidation of methane to methanol using only oxygen and water at low temperatures, but the genesis and nature of the active sites are currently unknown. Herein, we demonst
Publikováno v:
ACS Central Science, Vol 2, Iss 6, Pp 424-429 (2016)
ACS Central Science
ACS Central Science
The direct catalytic conversion of methane to liquid oxygenated compounds, such as methanol or dimethyl ether, at low temperature using molecular oxygen is a grand challenge in C–H activation that has never been met with synthetic, heterogeneous ca
Autor:
Vladimir K. Michaelis, Karthik Narsimhan, William R. Gunther, Robert G. Griffin, Yuriy Román-Leshkov, Guinevere Mathies
Publikováno v:
Journal of the American Chemical Society. 137(5)
The selective low temperature oxidation of methane is an attractive yet challenging pathway to convert abundant natural gas into value added chemicals. Copper-exchanged ZSM-5 and mordenite (MOR) zeolites have received attention due to their ability t