Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Karthik Hullahalli"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Here, using Citrobacter rodentium colonization of mice as a model, the authors characterize the impact of pathogen dose on the number of bacteria that initiate infection in the mouse gut, providing a framework for quantifying the host bottlenecks tha
Externí odkaz:
https://doaj.org/article/174350cdddf04245943b68ff4a1bf4ba
Autor:
Joshua M Kirsch, Shannon Ely, Madison E Stellfox, Karthik Hullahalli, Phat Luong, Kelli L Palmer, Daria Van Tyne, Breck A Duerkop
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011424 (2023)
Insertion sequences (IS) are simple transposons implicated in the genome evolution of diverse pathogenic bacterial species. Enterococci have emerged as important human intestinal pathogens with newly adapted virulence potential and antibiotic resista
Externí odkaz:
https://doaj.org/article/4244f4d858254be781c4732ef81c4ed2
Autor:
Bolutife Fakoya, Karthik Hullahalli, Daniel H. F. Rubin, Deborah R. Leitner, Roma Chilengi, David A. Sack, Matthew K. Waldor
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Human challenge studies are instrumental for testing cholera vaccines, but these studies use outdated strains and require inpatient facilities. Here, we created next-generation isogenic Ogawa and Inaba O1 V. cholerae challenge strains (ZChol
Externí odkaz:
https://doaj.org/article/16de03fc57a943209fb73be604507da6
Autor:
Karthik Hullahalli, Matthew K Waldor
Publikováno v:
eLife, Vol 10 (2021)
The dissemination of pathogens through blood and their establishment within organs lead to severe clinical outcomes. However, the within-host dynamics that underlie pathogen spread to and clearance from systemic organs remain largely uncharacterized.
Externí odkaz:
https://doaj.org/article/b988598bf6724dc5a1987d091a56fbe5
Publikováno v:
mSystems, Vol 6, Iss 4 (2021)
ABSTRACT Pathogen population dynamics during infection are critical determinants of infection susceptibility and define patterns of dissemination. However, deciphering these dynamics, particularly founding population sizes in host organs and patterns
Externí odkaz:
https://doaj.org/article/c27ed0e94cfe4cc0856dce06c62a0142
Autor:
Valerie J. Price, Sara W. McBride, Karthik Hullahalli, Anushila Chatterjee, Breck A. Duerkop, Kelli L. Palmer
Publikováno v:
mSphere, Vol 4, Iss 4 (2019)
ABSTRACT CRISPR-Cas systems are barriers to horizontal gene transfer (HGT) in bacteria. Little is known about CRISPR-Cas interactions with conjugative plasmids, and studies investigating CRISPR-Cas/plasmid interactions in in vivo models relevant to i
Externí odkaz:
https://doaj.org/article/9306573beb6b4c9cbff038b7015839c5
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
Externí odkaz:
https://doaj.org/article/23886fc6327946cb9eb3698759418fc6
Publikováno v:
mBio, Vol 9, Iss 3 (2018)
ABSTRACT Antibiotic-resistant bacteria are critical public health concerns. Among the prime causative factors for the spread of antibiotic resistance is horizontal gene transfer (HGT). A useful model organism for investigating the relationship betwee
Externí odkaz:
https://doaj.org/article/39310335797a4713939b048625ff7e06
Publikováno v:
eLife, Vol 6 (2017)
CRISPR-Cas provides a barrier to horizontal gene transfer in prokaryotes. It was previously observed that functional CRISPR-Cas systems are absent from multidrug-resistant (MDR) Enterococcus faecalis, which only possess an orphan CRISPR locus, termed
Externí odkaz:
https://doaj.org/article/ed2bf288858d4cf5a4185d66f55b3ba8
Autor:
Karthik Hullahalli, Marinelle Rodrigues, Brendan D Schmidt, Xiang Li, Pooja Bhardwaj, Kelli L Palmer
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138890 (2015)
Clustered, Regularly Interspaced Short Palindromic Repeats and their associated Cas proteins (CRISPR-Cas) provide prokaryotes with a mechanism for defense against mobile genetic elements (MGEs). A CRISPR locus is a molecular memory of MGE encounters.
Externí odkaz:
https://doaj.org/article/7e76f1c14c494515994ab68e4692817c