Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Karthik B. Jeganathan"'
Autor:
Janine H. van Ree, Karthik B. Jeganathan, Raul O. Fierro Velasco, Cheng Zhang, Ismail Can, Masakazu Hamada, Hu Li, Darren J. Baker, Jan M. van Deursen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract PTEN is a multifaceted tumor suppressor that is highly sensitive to alterations in expression or function. The PTEN C-tail domain, which is rich in phosphorylation sites, has been implicated in PTEN stability, localization, catalytic activit
Externí odkaz:
https://doaj.org/article/64e268e5f57c49279fbd7d64e638b41e
Autor:
Ines Sturmlechner, Chance C. Sine, Karthik B. Jeganathan, Cheng Zhang, Raul O. Fierro Velasco, Darren J. Baker, Hu Li, Jan M. van Deursen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
To develop therapeutics that selectively eliminate pathological senescent cells it is important to understand their survival mechanisms. Here, the authors show that senescent cells manage to survive by keeping p53 activity in check through multiple m
Externí odkaz:
https://doaj.org/article/acbe3fbfd0cd4e49ada168a6fd190c50
Autor:
Somaira Nowsheen, Khaled Aziz, Kuntian Luo, Min Deng, Bo Qin, Jian Yuan, Karthik B. Jeganathan, Jia Yu, Henan Zhang, Wei Ding, Jan M. van Deursen, Zhenkun Lou
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Following double-strand break a cascade of events leads to the recruitment of repair factors to damaged sites. Here the authors identify ZNF506 as a key factor that mediates post-translational modification changes in H2AX affecting the DNA damage res
Externí odkaz:
https://doaj.org/article/900eef9ab9884019ae8190fe48d02ee3
Autor:
Robbyn L Weaver, Jazeel F Limzerwala, Ryan M Naylor, Karthik B Jeganathan, Darren J Baker, Jan M van Deursen
Publikováno v:
eLife, Vol 5 (2016)
BubR1 is a key component of the spindle assembly checkpoint (SAC). Mutations that reduce BubR1 abundance cause aneuploidization and tumorigenesis in humans and mice, whereas BubR1 overexpression protects against these. However, how supranormal BubR1
Externí odkaz:
https://doaj.org/article/88af7186e82648198f1f19cdb2ccc619
Autor:
Jan M. van Deursen, Hu Li, Ines Sturmlechner, Cheng Zhang, Jazeel F. Limzerwala, Daohong Zhou, Jian Zhong, Brian A. Davies, Karthik B. Jeganathan, David J. Katzmann, Yaxia Yuan, Jake A. Kloeber, Darren J. Baker, Alan P. Fields, Raul O. Fierro Velasco
Publikováno v:
Nat Cancer
FoxM1 activates genes that regulate S-G2-M cell-cycle progression and, when overexpressed, is associated with poor clinical outcome in multiple cancers. Here we identify FoxM1 as a tumor suppressor in mice that, through its N-terminal domain, binds t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed4d578b7469e688c1e0f38383fcfa4
https://pubmed.ncbi.nlm.nih.gov/34841254
https://pubmed.ncbi.nlm.nih.gov/34841254
Autor:
Do Young Lim, Jan M. van Deursen, Tamas Ordog, Hu Li, Cheng Zhang, Jeong Heon Lee, Jeremy T. Stutchman, Darren J. Baker, Remi-Martin Laberge, Virginia Smith Shapiro, Ismail Can, Karthik B. Jeganathan, Chance C. Sine, Masakazu Hamada, Jan Grasic, Naomi Hamada, Erik-Jan van Deursen, Ines Sturmlechner, David J. Friedman
Publikováno v:
Science
Science, 374(6567):eabb3420. AMER ASSOC ADVANCEMENT SCIENCE
Science, 374(6567):eabb3420. AMER ASSOC ADVANCEMENT SCIENCE
The clock is ticking for senescent cells Senescent cells promote their own recognition and removal through the immune system by generating a bioactive secretome called the senescence-associated secretory phenotype (SASP). Sturmlechner et al . report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b874dbc3dfe671247c7754225c7eeef
https://doi.org/10.1126/science.abb3420
https://doi.org/10.1126/science.abb3420
Autor:
Ines Sturmlechner, Chance C. Sine, Karthik B. Jeganathan, Cheng Zhang, Raul O. Fierro Velasco, Darren J. Baker, Hu Li, Jan M. van Deursen
Publikováno v:
Nature Communications, 13(1):3722. Nature Publishing Group
Super-enhancers regulate genes with important functions in processes that are cell type-specific or define cell identity. Mouse embryonic fibroblasts establish 40 senescence-associated super-enhancers regardless of how they become senescent, with 50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d171fac0482b8a556bb16ad8b3eaabd
https://pubmed.ncbi.nlm.nih.gov/35764649
https://pubmed.ncbi.nlm.nih.gov/35764649
Autor:
Jan M. van Deursen, Floris Foijer, Cynthia J. Sieben, Ines Sturmlechner, Cheng Zhang, Grace G. Nelson, Karthik B. Jeganathan, Willemijn H. van Deursen, Hu Li, Bjorn Bakker, Darren J. Baker
Publikováno v:
The Journal of Clinical Investigation, 130(1), 171-188. AMER SOC CLINICAL INVESTIGATION INC
J Clin Invest
J Clin Invest
Mosaic-variegated aneuploidy (MVA) syndrome is a rare childhood disorder characterized by biallelic BUBR1, CEP57, or TRIP13 aberrations; increased chromosome missegregation; and a broad spectrum of clinical features, including various cancers, congen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a89c8ec8d01aa925492db159378e7c
https://research.rug.nl/en/publications/e82b754d-8c2a-4bac-b97f-9aa021c61734
https://research.rug.nl/en/publications/e82b754d-8c2a-4bac-b97f-9aa021c61734
Autor:
Tobias Wijshake, Liviu A Malureanu, Darren J Baker, Karthik B Jeganathan, Bart van de Sluis, Jan M van Deursen
Publikováno v:
PLoS Genetics, Vol 8, Iss 12, p e1003138 (2012)
Mosaic Variegated Aneuploidy (MVA) syndrome is a rare autosomal recessive disorder characterized by inaccurate chromosome segregation and high rates of near-diploid aneuploidy. Children with MVA syndrome die at an early age, are cancer prone, and hav
Externí odkaz:
https://doaj.org/article/e660110b9f42454f9f63639bbd07ba42
Autor:
Masakazu Hamada, Cynthia J. Sieben, Raul O. Fierro Velasco, Nazneen Rahman, Khaled Aziz, David J. Katzmann, Jan M. van Deursen, Karthik B. Jeganathan, Brian A. Davies
Publikováno v:
Journal of Clinical Investigation, 128, 8, pp. 3517-3534
Journal of Clinical Investigation, 128, 3517-3534
The Journal of Clinical Investigation
Journal of Clinical Investigation, 128, 3517-3534
The Journal of Clinical Investigation
Contains fulltext : 196242.pdf (Publisher’s version ) (Open Access) A homozygous truncating frameshift mutation in CEP57 (CEP57T/T) has been identified in a subset of mosaic-variegated aneuploidy (MVA) patients; however, the physiological roles of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3509c7b9ed6c0cdd3e427254c662ed8a
https://doi.org/10.1172/jci120316
https://doi.org/10.1172/jci120316