Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Karthik A, Jagadeesh"'
Autor:
Carina Shiau, Jennifer Su, Jimmy A. Guo, Theodore S. Hong, Jennifer Y. Wo, Karthik A. Jagadeesh, William L. Hwang
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most treatment refractory and lethal malignancies. The diversity of endothelial cell (EC) lineages in the tumor microenvironment (TME) impacts the efficacy of antineoplastic therapies, which in tu
Externí odkaz:
https://doaj.org/article/43dfbc2540184333b791660c55d40a82
Autor:
Daniel P. Dever, Samantha G. Scharenberg, Joab Camarena, Eric J. Kildebeck, Joseph T. Clark, Renata M. Martin, Rasmus O. Bak, Yuming Tang, Monika Dohse, Johannes A. Birgmeier, Karthik A. Jagadeesh, Gill Bejerano, Ann Tsukamoto, Natalia Gomez-Ospina, Nobuko Uchida, Matthew H. Porteus
Publikováno v:
iScience, Vol 15, Iss , Pp 524-535 (2019)
Summary: Human neural stem cells (NSCs) offer therapeutic potential for neurodegenerative diseases, such as inherited monogenic nervous system disorders, and neural injuries. Gene editing in NSCs (GE-NSCs) could enhance their therapeutic potential. W
Externí odkaz:
https://doaj.org/article/2fa9e32ecf84457fb9e04fdb55b3dba9
Autor:
Daniel J. Weiner, Ajay Nadig, Karthik A. Jagadeesh, Kushal K. Dey, Benjamin M. Neale, Elise B. Robinson, Konrad J. Karczewski, Luke J. O’Connor
Publikováno v:
Nature. 614:492-499
Autor:
Karthik A. Jagadeesh, Kushal K. Dey, Daniel T. Montoro, Rahul Mohan, Steven Gazal, Jesse M. Engreitz, Ramnik J. Xavier, Alkes L. Price, Aviv Regev
Publikováno v:
Nature Genetics. 54:1479-1492
Autor:
Steven Gazal, Omer Weissbrod, Farhad Hormozdiari, Kushal K. Dey, Joseph Nasser, Karthik A. Jagadeesh, Daniel J. Weiner, Huwenbo Shi, Charles P. Fulco, Luke J. O’Connor, Bogdan Pasaniuc, Jesse M. Engreitz, Alkes L. Price
Publikováno v:
Nature genetics, vol 54, iss 6
Nat Genet
Nat Genet
Disease-associated single-nucleotide polymorphisms (SNPs) generally do not implicate target genes, as most disease SNPs are regulatory. Many SNP-to-gene (S2G) linking strategies have been developed to link regulatory SNPs to the genes that they regul
Autor:
Kathryn Geiger-Schuller, Basak Eraslan, Olena Kuksenko, Kushal K. Dey, Karthik A. Jagadeesh, Pratiksha I. Thakore, Ozge Karayel, Andrea R. Yung, Anugraha Rajagopalan, Ana M Meireles, Karren Dai Yang, Liat Amir-Zilberstein, Toni Delorey, Devan Phillips, Raktima Raychowdhury, Christine Moussion, Alkes L. Price, Nir Hacohen, John G. Doench, Caroline Uhler, Orit Rozenblatt-Rosen, Aviv Regev
Publikováno v:
bioRxiv
E3 ligases regulate key processes, but many of their roles remain unknown. Using Perturb-seq, we interrogated the function of 1,130 E3 ligases, partners and substrates in the inflammatory response in primary dendritic cells (DCs). Dozens impacted the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d8f305a048b8acb0f805d0af1ceb7e
https://europepmc.org/articles/PMC9900845/
https://europepmc.org/articles/PMC9900845/
Autor:
William L. Hwang, Karthik A. Jagadeesh, Jimmy A. Guo, Hannah I. Hoffman, Carina Shiau, Jennifer Su, Payman Yadollahpour, Jason W. Reeves, Youngmi Kim, Sean Kim, Mark Gregory, Prajan Divakar, Eric Miller, Michael Rhodes, Sarah Warren, Erroll Rueckert, Kit Fuhrman, Daniel R. Zollinger, Robin Fropf, Joseph M. Beechem, Arnav Mehta, Toni Delorey, Cristin McCabe, Jaimie L. Barth, Piotr Zelga, Cristina R. Ferrone, Motaz Qadan, Keith D. Lillemoe, Rakesh K. Jain, Jennifer Y. Wo, Theodore S. Hong, Ramnik Xavier, Orit Rozenblatt-Rosen, Andrew J. Aguirre, Carlos Fernandez-Del Castillo, Andrew S. Liss, Mari Mino-Kenudson, David T. Ting, Tyler Jacks, Aviv Regev
Publikováno v:
Cancer Research. 82:SY12-04
Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer mortality in the United States by 2030. Given that resistance to cytotoxic therapy is pervasive, there is a critical need to elucidate salient gene expressi
Autor:
William L. Hwang, Karthik A. Jagadeesh, Jimmy A. Guo, Hannah I. Hoffman, Payman Yadollahpour, Jason W. Reeves, Rahul Mohan, Eugene Drokhlyansky, Nicholas Van Wittenberghe, Orr Ashenberg, Samouil L. Farhi, Denis Schapiro, Prajan Divakar, Eric Miller, Daniel R. Zollinger, George Eng, Jason M. Schenkel, Jennifer Su, Carina Shiau, Patrick Yu, William A. Freed-Pastor, Domenic Abbondanza, Arnav Mehta, Joshua Gould, Conner Lambden, Caroline B. M. Porter, Alexander Tsankov, Danielle Dionne, Julia Waldman, Michael S. Cuoco, Lan Nguyen, Toni Delorey, Devan Phillips, Jaimie L. Barth, Marina Kem, Clifton Rodrigues, Debora Ciprani, Jorge Roldan, Piotr Zelga, Vjola Jorgji, Jonathan H. Chen, Zackery Ely, Daniel Zhao, Kit Fuhrman, Robin Fropf, Joseph M. Beechem, Jay S. Loeffler, David P. Ryan, Colin D. Weekes, Cristina R. Ferrone, Motaz Qadan, Martin J. Aryee, Rakesh K. Jain, Donna S. Neuberg, Jennifer Y. Wo, Theodore S. Hong, Ramnik Xavier, Andrew J. Aguirre, Orit Rozenblatt-Rosen, Mari Mino-Kenudson, Carlos Fernandez-del Castillo, Andrew S. Liss, David T. Ting, Tyler Jacks, Aviv Regev
Publikováno v:
Nat Genet
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory cancer. Molecular stratification in pancreatic cancer remains rudimentary and does not yet inform clinical management or therapeutic development. Here, we construct a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52fea7e3e72f452826d1f68df747811
https://europepmc.org/articles/PMC10290535/
https://europepmc.org/articles/PMC10290535/
Autor:
Daniel J. Weiner, Ajay Nadig, Karthik A. Jagadeesh, Kushal K. Dey, Benjamin M. Neale, Elise B. Robinson, Konrad J. Karczewski, Luke J. O’Connor
Both common and rare genetic variants influence complex traits and common diseases. Genome-wide association studies have discovered thousands of common-variant associations, and more recently, large-scale exome sequencing studies have identified rare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61d9c2f067d7be87ad39741bf0ca1a0d
https://doi.org/10.1101/2022.07.06.22277335
https://doi.org/10.1101/2022.07.06.22277335
Publikováno v:
Nature Computational Science. 1:272-279
DNA profiling has become an essential tool for crime solving and prevention, and CODIS (Combined DNA Index System) criminal investigation databases have flourished at the national, state and even local level. However, reports suggest that the DNA pro