Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Karthigayan Shanmugasundaram"'
Autor:
Karthigayan Shanmugasundaram, Bijaya K. Nayak, William E. Friedrichs, Dharam Kaushik, Ronald Rodriguez, Karen Block
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
NADPH oxidase NOX4 has been linked to poor cancer survival. Here the authors show that NOX4 regulates drug resistance in renal cancer carcinoma by regulating PKM2 and that NOX4 activity is allosterically activated by reduced mitochondrial ATP levels
Externí odkaz:
https://doaj.org/article/b6112e9eaddb4fcbbe6870525a0bd64f
Autor:
John P Fitzgerald, Bijaya Nayak, Karthigayan Shanmugasundaram, William Friedrichs, Sunil Sudarshan, Assaad A Eid, Thomas DeNapoli, Dipen J Parekh, Yves Gorin, Karen Block
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30712 (2012)
Inflammatory cytokines are detected in the plasma of patients with renal cell carcinoma (RCC) and are associated with poor prognosis. However, the primary cell type involved in producing inflammatory cytokines and the biological significance in RCC r
Externí odkaz:
https://doaj.org/article/f966c6a97bb24d6f9387878eec669568
Autor:
Sunil Sudarshan, Karthigayan Shanmugasundaram, Susan L Naylor, Shu Lin, Carolina B Livi, Christine F O'Neill, Dipen J Parekh, I-Tien Yeh, Lu-Zhe Sun, Karen Block
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21037 (2011)
Germline mutations of FH, the gene that encodes for the tricarboxylic acid TCA (TCA) cycle enzyme fumarate hydratase, are associated with an inherited form of cancer referred to as Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC). Individuals
Externí odkaz:
https://doaj.org/article/afe678de0b564340818bc772790d6cab
Autor:
Denise S. O'Keefe, Hanzhang Wang, Deepak Pruthi, Michael A. Liss, Wasim H. Chowdhury, Ronald Rodriguez, Karthigayan Shanmugasundaram, Gabriela Gonzalez, Keith A. Ashcraft, Hao Zhang, Dean Bacich, Pankil Shah, Dharam Kaushik, Karen Block, Cooper B. Tye, Amanda L. Watson, Ahmed M. Mansour, Alia Nazarullah
Publikováno v:
Transl Res
Nuclear NADPH oxidase-4 (Nox4) is a key component of metabolic reprogramming and is often overexpressed in renal cell carcinoma (RCC). However, its prognostic role in RCC remains unclear. Here we examined the significance of nuclear Nox4 on disease p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e464a93d680e7f4b596403bc265017
https://doi.org/10.1016/j.trsl.2020.05.009
https://doi.org/10.1016/j.trsl.2020.05.009
Publikováno v:
J Biol Chem
Chromosome translocation can lead to chimeric proteins that may become oncogenic drivers. A classic example is the fusion of the BCR activator of RhoGEF and GTPase and the ABL proto-oncogene nonreceptor tyrosine kinase, a result of a chromosome abnor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f2b9fc5b8cddf7c60c1f95b4d40762
https://pubmed.ncbi.nlm.nih.gov/32439806
https://pubmed.ncbi.nlm.nih.gov/32439806
Autor:
Hai Rao, Peng Shao, Karthigayan Shanmugasundaram, Han Chen, Stanton F. McHardy, Bismarck Campos, Tuoping Luo
Publikováno v:
J Biol Chem
Proteolysis targeting chimeras (PROTACs) are bivalent molecules that bring a cellular protein to a ubiquitin ligase E3 for ubiquitination and subsequent degradation. Although PROTAC has emerged as a promising therapeutic means for cancers as it rewir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11f48ade4e10341f22c14ea00f2bad8
https://pubmed.ncbi.nlm.nih.gov/31511327
https://pubmed.ncbi.nlm.nih.gov/31511327
Autor:
William E. Friedrichs, Bijaya K. Nayak, Jeffrey L. Barnes, Mandakini Patel, Rita C. Cavaglierii, Karthigayan Shanmugasundaram, Karen Block
Publikováno v:
Diabetes
Hypoxia-inducible factor (HIF)-1 mediates hypoxia- and chronic kidney disease–induced fibrotic events. Here, we assessed whether HIF-1 blockade attenuates the manifestations of diabetic nephropathy in a type 1 diabetic animal model, OVE26. YC-1 [3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d60cd9e7b483acda6519c1e47631e37c
https://doi.org/10.2337/db15-0519
https://doi.org/10.2337/db15-0519
Autor:
Karthigayan Shanmugasundaram, Sunil Sudarshan, Eun Hee Shim, Bijaya K. Nayak, Karen Block, Carolina B. Livi
Publikováno v:
Journal of Biological Chemistry. 289:24691-24699
Inactivating mutations of the gene encoding the tricarboxylic acid cycle enzyme fumarate hydratase (FH) have been linked to an aggressive variant of hereditary kidney cancer (hereditary leiomyomatosis and renal cell cancer). These tumors accumulate m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565a9b579cbe646f4bfaffac96852e8c
https://doi.org/10.1074/jbc.m114.568162
https://doi.org/10.1074/jbc.m114.568162
Autor:
Puntip Tantiwong, Sumathy Mohan, Nicolas Musi, John J. Dubé, Karthigayan Shanmugasundaram, Apiradee Sriwijitkamol, Hanyu Liang, Sara E. Espinoza, Ralph A. DeFronzo
Publikováno v:
The Journal of Physiology. 591:2897-2909
Free fatty acids (FFAs) have been implicated in the pathogenesis of insulin resistance. Reducing plasma FFA concentration in obese and type 2 diabetic (T2DM) subjects improves insulin sensitivity. However, the molecular mechanism by which FFA reducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2337713bf4e3fdf62f1a86fee0df3688
https://doi.org/10.1113/jphysiol.2012.247510
https://doi.org/10.1113/jphysiol.2012.247510
Autor:
Bijaya K. Nayak, Karthigayan Shanmugasundaram, William E. Friedrichs, Ronald Rodriguez, Karen Block, Dharam Kaushik
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The molecular mechanisms that couple glycolysis to cancer drug resistance remain unclear. Here we identify an ATP-binding motif within the NADPH oxidase isoform, NOX4, and show that ATP directly binds and negatively regulates NOX4 activity. We find t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18bc00eb4dc0b368ce4aacf71a0ad4b2
https://pubmed.ncbi.nlm.nih.gov/29051480
https://pubmed.ncbi.nlm.nih.gov/29051480