Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Karthic Swaminathan"'
Publikováno v:
Cells, Vol 9, Iss 7, p 1635 (2020)
Cells migrating over 2D substrates are required to polymerise actin at the leading edge to form lamellipodia protrusions and nascent adhesions to anchor the protrusion to the substrate. The major actin nucleator in lamellipodia formation is the Arp2/
Externí odkaz:
https://doaj.org/article/66b35bbd6ae14a45be1aa2efc516d9e1
Autor:
Liu Yang, Martina Munck, Karthic Swaminathan, Larisa E Kapinos, Angelika A Noegel, Sascha Neumann
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71850 (2013)
BackgroundIn eukaryotes the genetic material is enclosed by a continuous membrane system, the nuclear envelope (NE). Along the NE specific proteins assemble to form meshworks and mutations in these proteins have been described in a group of human dis
Externí odkaz:
https://doaj.org/article/be5a7a7122af45e9837089214e80377f
Autor:
Emma L. Wilkinson, Louise C. Brennan, Olivia J. Harrison, Zoe Crane‐Smith, Philippe Gautier, Margaret A. Keighren, Peter Budd, Karthic Swaminathan, Laura M. Machesky, Sarah L. Allinson, Ian J. Jackson, Richard L. Mort
Publikováno v:
Pigment Cell & Melanoma Research. 36:71-77
Genetic approaches that allow lineage tracing are essential to our future understanding of melanocytes and melanoma. To date, the approaches used to label melanocytes in mice have relied on random integration of transgenes driven by the promoters of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4126b1b0957e41ac6aad1464c4446c
https://doi.org/10.1111/pcmr.13076
https://doi.org/10.1111/pcmr.13076
Autor:
Parisa Naeem, Adi Baumgartner, Nader Ghaderi, Farshid Sefat, Maysa Alhawamdeh, Saeed Heidari, Fanila Shahzad, Karthic Swaminathan, Pouria Akhbari, Mohammad Isreb, Diana Anderson, Andrew Wright, Mojgan Najafzadeh
Publikováno v:
Journal of Cellular and Molecular Medicine, 2023, Vol.27(2) [Peer Reviewed Journal]
Incidence of Malignant Melanoma has become the 5th in the UK. To date, the major anticancer therapeutics include cell therapy, immunotherapy, gene therapy and nanotechnology-based strategies. Recently, extracellular vesicles, especially exosomes, hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e458689b17d5f809de276a84d4c8315
https://pubmed.ncbi.nlm.nih.gov/36545841
https://pubmed.ncbi.nlm.nih.gov/36545841
Autor:
Farah Jaber-Hijazi, Karthic Swaminathan, Kathryn Gilroy, Alexander T. Wenzel, Anthony Lagnado, Kristina Kirschner, Neil Robertson, Claire Reid, Neil Fullarton, Jeff Pawlikowski, Karen Blyth, Jill P. Mesirov, Taranjit Singh Rai, João F. Passos, Laura M. Machesky, Peter D. Adams
Histone chaperone HIRA is thought to play a role in both early development and aging, but little is known about connections between the two processes. Here, we explore this relationship using a lineage-specific knockout mouse model, TyrCre::Hirafl/fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a378d6a6790a57be336141e1e20372e
https://doi.org/10.1101/2022.04.22.489166
https://doi.org/10.1101/2022.04.22.489166
Autor:
Laura M. Machesky, Hans-Henning Arnold, Heather J. Spence, Vasileios Papalazarou, Klemens Rottner, Karthic Swaminathan, Ines Lahmann, Colin Nixon, Manuel Salmerón-Sánchez, Farah Jaber-Hijazi
Publikováno v:
Development (Cambridge, England)
England
article-version (VoR) Version of Record
England
article-version (VoR) Version of Record
The Arp2/3 complex is essential for the assembly of branched filamentous actin, but its role in physiology and development is surprisingly little understood. Melanoblasts deriving from the neural crest migrate along the developing embryo and traverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2daf30fbae3e38d5a622df5aa0c81fd3
https://eprints.gla.ac.uk/226709/1/226709.pdf
https://eprints.gla.ac.uk/226709/1/226709.pdf
Publikováno v:
Cells, Vol 9, Iss 1635, p 1635 (2020)
Cells
Volume 9
Issue 7
Cells
Volume 9
Issue 7
Cells migrating over 2D substrates are required to polymerise actin at the leading edge to form lamellipodia protrusions and nascent adhesions to anchor the protrusion to the substrate. The major actin nucleator in lamellipodia formation is the Arp2/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ebedcecdff93dd95e0b6871c5e1766b
https://www.mdpi.com/2073-4409/9/7/1635
https://www.mdpi.com/2073-4409/9/7/1635
Autor:
Karen Blyth, Peter D. Adams, Neil Fullarton, Farah Jaber-Hijazi, Kristina Kirschner, Karthic Swaminathan, Jeff S. Pawlikowski, Neil Robertson, Laura M. Machesky, Claire Brock
Publikováno v:
Pigment Cell & Melanoma Research. 31:736-777
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06de908ce48d313f4b416ae10a271469
https://doi.org/10.1111/pcmr.12734
https://doi.org/10.1111/pcmr.12734
Autor:
Peter A. Thomason, Clelia Amato, Laura M. Machesky, Andrew J. Davidson, Shehab Ismail, Robert H. Insall, Karthic Swaminathan
Publikováno v:
Amato, C, Thomason, P A, Davidson, A J, Swaminathan, K, Ismail, S, Machesky, L M & Insall, R H 2019, ' WASP restricts active rac to maintain cells' front-rear polarization ', Current Biology, vol. 29, no. 24, pp. 4169-4182.e4 . https://doi.org/10.1016/j.cub.2019.10.036
Current Biology
Current Biology
Summary Efficient motility requires polarized cells, with pseudopods at the front and a retracting rear. Polarization is maintained by restricting the pseudopod catalyst, active Rac, to the front. Here, we show that the actin nucleation-promoting fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3e71dff1cd156f84ba7ef5d490c1e1
https://www.pure.ed.ac.uk/ws/files/139989163/Davidson_A_WASP_restricts....pdf
https://www.pure.ed.ac.uk/ws/files/139989163/Davidson_A_WASP_restricts....pdf
Autor:
Colin Nixon, Steven Reid, Vasileios Papalazarou, Laura M. Machesky, Ewan J. McGhee, Lisa J. Neilson, David M. Bryant, Ralf H. Adams, Francesca Patella, Karthic Swaminathan, Sandeep Dhayade, Jens Serneels, Karen Blyth, Álvaro Román-Fernández, Shehab Ismail, Manuel Salmerón-Sánchez, Alice Santi, Massimiliano Mazzone, Sara Zanivan, Yasmin ElMaghloob, Emily J. Kay, Juan Ramon Hernandez-Fernaud, Leo M. Carlin, Dimitris Athineos, Anne Theres Henze, John B. G. Mackey
Publikováno v:
The EMBO Journal
Tumor progression alters the composition and physical properties of the extracellular matrix. Particularly, increased matrix stiffness has profound effects on tumor growth and metastasis. While endothelial cells are key players in cancer progression,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16948b84697fa3e00e73d67982450a20
https://doi.org/10.15252/embj.201694912
https://doi.org/10.15252/embj.201694912