Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Karsten Krug"'
Autor:
Matteo Gentili, Bingxu Liu, Malvina Papanastasiou, Deborah Dele-Oni, Marc A. Schwartz, Rebecca J. Carlson, Aziz M. Al’Khafaji, Karsten Krug, Adam Brown, John G. Doench, Steven A. Carr, Nir Hacohen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
STING is an intracellular sensor of pathogen- or host-derived DNA. In this study, the authors identify an ESCRT complex that regulates STING degradation, thus acting as a homeostatic regulator of STING signalling and type-I interferon responses.
Externí odkaz:
https://doaj.org/article/d27c75d5f7194b308e5471c9ab586aee
Autor:
Prasidda Khadka, Zachary J. Reitman, Sophie Lu, Graham Buchan, Gabrielle Gionet, Frank Dubois, Diana M. Carvalho, Juliann Shih, Shu Zhang, Noah F. Greenwald, Travis Zack, Ofer Shapira, Kristine Pelton, Rachel Hartley, Heather Bear, Yohanna Georgis, Spandana Jarmale, Randy Melanson, Kevin Bonanno, Kathleen Schoolcraft, Peter G. Miller, Alexandra L. Condurat, Elizabeth M. Gonzalez, Kenin Qian, Eric Morin, Jaldeep Langhnoja, Leslie E. Lupien, Veronica Rendo, Jeromy Digiacomo, Dayle Wang, Kevin Zhou, Rushil Kumbhani, Maria E. Guerra Garcia, Claire E. Sinai, Sarah Becker, Rachel Schneider, Jayne Vogelzang, Karsten Krug, Amy Goodale, Tanaz Abid, Zohra Kalani, Federica Piccioni, Rameen Beroukhim, Nicole S. Persky, David E. Root, Angel M. Carcaboso, Benjamin L. Ebert, Christine Fuller, Ozgun Babur, Mark W. Kieran, Chris Jones, Hasmik Keshishian, Keith L. Ligon, Steven A. Carr, Timothy N. Phoenix, Pratiti Bandopadhayay
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Abstract The role of PPM1D mutations in de novo gliomagenesis has not been systematically explored. Here we analyze whole genome sequences of 170 pediatric high-grade gliomas and find that truncating mutations in PPM1D that increase the stability of
Externí odkaz:
https://doaj.org/article/05d88dcae9c94b0ba00bbf84c4d8c770
A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling
Autor:
Chi-Hong Wu, Vedakumar Tatavarty, Pierre M Jean Beltran, Andrea A Guerrero, Hasmik Keshishian, Karsten Krug, Melanie A MacMullan, Li Li, Steven A Carr, Jeffrey R Cottrell, Gina G Turrigiano
Publikováno v:
eLife, Vol 11 (2022)
Homeostatic synaptic plasticity requires widespread remodeling of synaptic signaling and scaffolding networks, but the role of post-translational modifications in this process has not been systematically studied. Using deep-scale quantitative analysi
Externí odkaz:
https://doaj.org/article/62dee5cecd974444b9a59db1da6ab44d
Autor:
Shankha Satpathy, Eric J. Jaehnig, Karsten Krug, Beom-Jun Kim, Alexander B. Saltzman, Doug W. Chan, Kimberly R. Holloway, Meenakshi Anurag, Chen Huang, Purba Singh, Ari Gao, Noel Namai, Yongchao Dou, Bo Wen, Suhas V. Vasaikar, David Mutch, Mark A. Watson, Cynthia Ma, Foluso O. Ademuyiwa, Mothaffar F. Rimawi, Rachel Schiff, Jeremy Hoog, Samuel Jacobs, Anna Malovannaya, Terry Hyslop, Karl R. Clauser, D. R. Mani, Charles M. Perou, George Miles, Bing Zhang, Michael A. Gillette, Steven A. Carr, Matthew J. Ellis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Connecting genomics and proteomics allows the development of more efficient and specific treatments for cancer. Here, the authors develop proteogenomic methods to defining cancer signaling in-vivo starting from core needle biopsies and with applicati
Externí odkaz:
https://doaj.org/article/1139337b9d47460b818a84e3816a1de9
Autor:
Hasmik Keshishian, E Robert McDonald III, Filip Mundt, Randy Melanson, Karsten Krug, Dale A Porter, Luke Wallace, Dominique Forestier, Bokang Rabasha, Sara E Marlow, Judit Jane‐Valbuena, Ellen Todres, Harrison Specht, Margaret Lea Robinson, Pierre M Jean Beltran, Ozgun Babur, Meagan E Olive, Javad Golji, Eric Kuhn, Michael Burgess, Melanie A MacMullan, Tomas Rejtar, Karen Wang, DR Mani, Shankha Satpathy, Michael A Gillette, William R Sellers, Steven A Carr
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 9, Pp n/a-n/a (2021)
Abstract Reliable methods to quantify dynamic signaling changes across diverse pathways are needed to better understand the effects of disease and drug treatment in cells and tissues but are presently lacking. Here, we present SigPath, a targeted mas
Externí odkaz:
https://doaj.org/article/8c21ac714ff142d89c9c58dde8847a35
Autor:
Lenka Halova, David Cobley, Mirita Franz-Wachtel, Tingting Wang, Kaitlin R. Morrison, Karsten Krug, Nicolas Nalpas, Boris Maček, Iain M. Hagan, Sean J. Humphrey, Janni Petersen
Publikováno v:
Open Biology, Vol 11, Iss 4 (2021)
Fluctuations in TOR, AMPK and MAP-kinase signalling maintain cellular homeostasis and coordinate growth and division with environmental context. We have applied quantitative, SILAC mass spectrometry to map TOR and nutrient-controlled signalling in th
Externí odkaz:
https://doaj.org/article/52572a9d94fa427cb6902e05c02baba9
Autor:
David Cobley, Lenka Hálová, Marie Schauries, Adrian Kaczmarek, Mirita Franz-Wachtel, Wei Du, Karsten Krug, Boris Maček, Janni Petersen
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172740 (2017)
Tight coupling of cell growth and cell cycle progression enable cells to adjust their rate of division, and therefore size, to the demands of proliferation in varying nutritional environments. Nutrient stress promotes inhibition of Target Of Rapamyci
Externí odkaz:
https://doaj.org/article/43e7c48d8a1441029d2049f2f39ece76
Autor:
Meenakshi Anurag, Eric J. Jaehnig, Karsten Krug, Jonathan T. Lei, Erik J. Bergstrom, Beom-Jun Kim, Tanmayi D. Vashist, Anh Minh Tran Huynh, Yongchao Dou, Xuxu Gou, Chen Huang, Zhiao Shi, Bo Wen, Viktoriya Korchina, Richard A. Gibbs, Donna M. Muzny, Harshavardhan Doddapaneni, Lacey E. Dobrolecki, Henry Rodriguez, Ana I. Robles, Tara Hiltke, Michael T. Lewis, Julie R. Nangia, Maryam Nemati Shafaee, Shunqiang Li, Ian S. Hagemann, Jeremy Hoog, Bora Lim, C. Kent Osborne, D.R. Mani, Michael A. Gillette, Bing Zhang, Gloria V. Echeverria, George Miles, Mothaffar F. Rimawi, Steven A. Carr, Foluso O. Ademuyiwa, Shankha Satpathy, Matthew J. Ellis
Publikováno v:
Cancer Discovery. 12:2586-2605
Microscaled proteogenomics was deployed to probe the molecular basis for differential response to neoadjuvant carboplatin and docetaxel combination chemotherapy for triple-negative breast cancer (TNBC). Proteomic analyses of pretreatment patient biop
Autor:
Matthew J. Ellis, Shankha Satpathy, Foluso O. Ademuyiwa, Steven A. Carr, Mothaffar F. Rimawi, George Miles, Gloria V. Echeverria, Bing Zhang, Michael A. Gillette, D.R. Mani, C. Kent Osborne, Bora Lim, Jeremy Hoog, Ian S. Hagemann, Shunqiang Li, Maryam Nemati Shafaee, Julie R. Nangia, Michael T. Lewis, Tara Hiltke, Ana I. Robles, Henry Rodriguez, Lacey E. Dobrolecki, Harshavardhan Doddapaneni, Donna M. Muzny, Richard A. Gibbs, Viktoriya Korchina, Bo Wen, Zhiao Shi, Chen Huang, Xuxu Gou, Yongchao Dou, Anh Minh Tran Huynh, Tanmayi D. Vashist, Beom-Jun Kim, Erik J. Bergstrom, Jonathan T. Lei, Karsten Krug, Eric J. Jaehnig, Meenakshi Anurag
Microscaled proteogenomics was deployed to probe the molecular basis for differential response to neoadjuvant carboplatin and docetaxel combination chemotherapy for triple-negative breast cancer (TNBC). Proteomic analyses of pretreatment patient biop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2213f3db6710d869c1c4f3f803aa9523
https://doi.org/10.1158/2159-8290.c.6549759.v1
https://doi.org/10.1158/2159-8290.c.6549759.v1
Autor:
Matthew J. Ellis, Shankha Satpathy, Foluso O. Ademuyiwa, Steven A. Carr, Mothaffar F. Rimawi, George Miles, Gloria V. Echeverria, Bing Zhang, Michael A. Gillette, D.R. Mani, C. Kent Osborne, Bora Lim, Jeremy Hoog, Ian S. Hagemann, Shunqiang Li, Maryam Nemati Shafaee, Julie R. Nangia, Michael T. Lewis, Tara Hiltke, Ana I. Robles, Henry Rodriguez, Lacey E. Dobrolecki, Harshavardhan Doddapaneni, Donna M. Muzny, Richard A. Gibbs, Viktoriya Korchina, Bo Wen, Zhiao Shi, Chen Huang, Xuxu Gou, Yongchao Dou, Anh Minh Tran Huynh, Tanmayi D. Vashist, Beom-Jun Kim, Erik J. Bergstrom, Jonathan T. Lei, Karsten Krug, Eric J. Jaehnig, Meenakshi Anurag
Supplementary Figure from Proteogenomic Markers of Chemotherapy Resistance and Response in Triple-Negative Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cddd49408408cb8699c178559bdada3
https://doi.org/10.1158/2159-8290.22541898
https://doi.org/10.1158/2159-8290.22541898