Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Karsten Kretschmer"'
Autor:
Acelya Yilmazer, Dimitra Maria Zevla, Rikke Malmkvist, Carlos Alejandro Bello Rodríguez, Pablo Undurraga, Emre Kirgin, Marie Boernert, David Voehringer, Olivia Kershaw, Susan Schlenner, Karsten Kretschmer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Foxp3+ regulatory T (Treg) cells of thymic (tTreg) and peripheral (pTreg) developmental origin are thought to synergistically act to ensure immune homeostasis, with self-reactive tTreg cells primarily constraining autoimmune responses. Here we exploi
Externí odkaz:
https://doaj.org/article/8e7a3d9fd837449e8611dbef2c6c1dc5
Autor:
Sebastian Dohnke, Stephanie Moehser, Alexey Surnov, Thomas Kurth, Rolf Jessberger, Karsten Kretschmer, Annette I. Garbe
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In T cells, processes such as migration and immunological synapse formation are accompanied by the dynamic reorganization of the actin cytoskeleton, which has been suggested to be mediated by regulators of RhoGTPases and by F-actin bundlers. SWAP-70
Externí odkaz:
https://doaj.org/article/a04c09087b1344e5a827e4d3f0519357
Autor:
Deepika Watts, Marthe Janßen, Mangesh Jaykar, Francesco Palmucci, Marc Weigelt, Cathleen Petzold, Angela Hommel, Tim Sparwasser, Ezio Bonifacio, Karsten Kretschmer
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Type 1 diabetes (T1D) represents a hallmark of the fatal multiorgan autoimmune syndrome affecting humans with abrogated Foxp3+ regulatory T (Treg) cell function due to Foxp3 gene mutations, but whether the loss of Foxp3+ Treg cell activity is indeed
Externí odkaz:
https://doaj.org/article/28e8d907fd7f450e96a96deb65167861
Autor:
Inna Tabansky, Derin B. Keskin, Deepika Watts, Cathleen Petzold, Michael Funaro, Warren Sands, Paul Wright, Edmond J. Yunis, Souhel Najjar, Betty Diamond, Yonghao Cao, David Mooney, Karsten Kretschmer, Joel N. H. Stern
Publikováno v:
Molecular Medicine, Vol 24, Iss 1, Pp 1-13 (2018)
Abstract Background Dendritic cells (DC) induce adaptive responses against foreign antigens, and play an essential role in maintaining peripheral tolerance to self-antigens. Therefore they are involved in preventing fatal autoimmunity. Selective deli
Externí odkaz:
https://doaj.org/article/359e3efd2cda48baa3c0a5c369963f74
Autor:
Luise Fischer, Caroline Herkner, Reni Kitte, Sebastian Dohnke, Julia Riewaldt, Karsten Kretschmer, Annette I. Garbe
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
The bone represents surprisingly dynamic structures that are subject to constant remodeling by the concerted action of bone-forming osteoblasts and bone-resorbing osteoclasts - two cell subsets of distinct developmental origin that are key in maintai
Externí odkaz:
https://doaj.org/article/50f07743c8a64dd99f2c040fe1da061e
Autor:
Maria Schreiber, Marc Weigelt, Anne Karasinsky, Konstantinos Anastassiadis, Sonja Schallenberg, Cathleen Petzold, Ezio Bonifacio, Karsten Kretschmer, Angela Hommel
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The IL-7/IL-7R pathway is essential for lymphocyte development and disturbances in the pathway can lead to immune deficiency or T cell mediated destruction. Here, the effect of transient hyperexpression of IL-7 was investigated on immune regulation a
Externí odkaz:
https://doaj.org/article/1d5afa95ec3a43938bed1d1a0f1ca645
Autor:
Tara L. Walker, Sonja Schallenberg, Nicole Rund, Lisa Grönnert, Ruslan Rust, Karsten Kretschmer, Gerd Kempermann
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Cross-talk between the peripheral immune system and the central nervous system is important for physiological brain health. T cells are required to maintain normal baseline levels of neural precursor proliferation in the hippocampus of adult mice. We
Externí odkaz:
https://doaj.org/article/7a55f72195454725b91bd2ef7c26a93e
Autor:
Anne-Margarete Brennecke, Sandra Düber, Bishnudeo Roy, Irene Thomsen, Annette I. Garbe, Frank Klawonn, Oliver Pabst, Karsten Kretschmer, Siegfried Weiss
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
We employed the B-Indu-Rag1 model in which the coding exon of recombination-activating gene 1 (Rag1) is inactivated by inversion. It is flanked by inverted loxP sites. Accordingly, B cell development is stopped at the pro/pre B-I cell precursor stage
Externí odkaz:
https://doaj.org/article/226bd695a41a43b0836860a7b1f1963f
Autor:
Kristin Freudenberg, Nadja Lindner, Sebastian Dohnke, Annette I. Garbe, Sonja Schallenberg, Karsten Kretschmer
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Under physiological conditions, CD4+ regulatory T (Treg) cells expressing the transcription factor Foxp3 are generated in the thymus [thymus-derived Foxp3+ Treg (tTregs) cells] and extrathymically at peripheral sites [peripherally induced Foxp3+ Treg
Externí odkaz:
https://doaj.org/article/dd51aea59911405da1134c0a18b8bd86
Autor:
Anke Fuchs, Mateusz Gliwiński, Nathali Grageda, Rachel Spiering, Abul K. Abbas, Silke Appel, Rosa Bacchetta, Manuela Battaglia, David Berglund, Bruce Blazar, Jeffrey A. Bluestone, Martin Bornhäuser, Anja ten Brinke, Todd M. Brusko, Nathalie Cools, Maria Cristina Cuturi, Edward Geissler, Nick Giannoukakis, Karolina Gołab, David A. Hafler, S. Marieke van Ham, Joanna Hester, Keli Hippen, Mauro Di Ianni, Natasa Ilic, John Isaacs, Fadi Issa, Dorota Iwaszkiewicz-Grześ, Elmar Jaeckel, Irma Joosten, David Klatzmann, Hans Koenen, Cees van Kooten, Olle Korsgren, Karsten Kretschmer, Megan Levings, Natalia Maria Marek-Trzonkowska, Marc Martinez-Llordella, Djordje Miljkovic, Kingston H.G. Mills, Joana P. Miranda, Ciriaco A. Piccirillo, Amy L. Putnam, Thomas Ritter, Maria Grazia Roncarolo, Shimon Sakaguchi, Silvia Sánchez-Ramón, Birgit Sawitzki, Ljiljana Sofronic-Milosavljevic, Megan Sykes, Qizhi Tang, Marta Vives-Pi, Herman Waldmann, Piotr Witkowski, Kathryn J. Wood, Silvia Gregori, Catharien M. U. Hilkens, Giovanna Lombardi, Phillip Lord, Eva M. Martinez-Caceres, Piotr Trzonkowski
Publikováno v:
Frontiers in Immunology, Vol 8 (2018)
Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medi
Externí odkaz:
https://doaj.org/article/6e6307c0ff3e4a65bfd0edfff5a979c4