Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Karsten Heusser"'
Autor:
Jorge Manuel, Eva Halbe, Ann Charlotte Ewald, Alex Hoff, Jens Jordan, Jens Tank, Karsten Heusser, Darius A. Gerlach
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionHypothalamic glucose-sensitive neural circuits, which regulate energy metabolism and can contribute to diseases such as obesity and type 2 diabetes, have been difficult to study in humans. We developed an approach to assess hypothalamic f
Externí odkaz:
https://doaj.org/article/5a2a5c59087f48b9a9ce2f1c82992609
Autor:
Marcus Thudium, Stefan Moestl, Fabian Hoffmann, Alex Hoff, Evgeniya Kornilov, Karsten Heusser, Jens Tank, Martin Soehle
Publikováno v:
PLoS ONE, Vol 18, Iss 6 (2023)
Purpose Recently, cerebral autoregulation indices based on moving correlation indices between mean arterial pressure (MAP) and cerebral oximetry (NIRS, ORx) or transcranial Doppler (TCD)-derived middle cerebral artery flow velocity (Mx) have been int
Externí odkaz:
https://doaj.org/article/b028b5af4aec4cf3a1a8fe7090572747
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2023)
IntroductionMechanistic studies suggested that excess sympathetic activity promotes arterial hypertension while worsening insulin sensitivity. Older patients with type 2 diabetes are at particularly high cardiovascular and metabolic risk. However, da
Externí odkaz:
https://doaj.org/article/5eef2f2148884a5b8d527d507469bee4
Autor:
Darius A. Gerlach, Andrea Maier, Jorge Manuel, Anja Bach, Alex Hoff, Jan‐Niklas Hönemann, Karsten Heusser, Dirk Voit, Jens Frahm, Jens Jordan, Jens Tank
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 21 (2022)
Background Discerning the mechanisms driving orthostatic symptoms in human beings remains challenging. Therefore, we developed a novel approach combining cardiac and cerebral real‐time magnetic resonance imaging, beat‐to‐beat physiological moni
Externí odkaz:
https://doaj.org/article/72072e6999a947d28fd9e876381170ea
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Arterial baroreflex assessment using vasoactive substances enables investigators to collect data pairs over a wide range of blood pressures and reflex reactions. These data pairs relate intervals between heartbeats or sympathetic neural activity to b
Externí odkaz:
https://doaj.org/article/394f9b98ac5f4b79905336a441523043
Autor:
Monique E. A. M. van Kleef, Karsten Heusser, André Diedrich, P. Liam Oey, Jens Tank, Jens Jordan, Peter J. Blankestijn, Bryan Williams, Wilko Spiering
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Background First in human studies suggest that endovascular baroreflex amplification (EVBA) lowers blood pressure (BP). To explore potential mechanisms for BP reduction, this study examines the effects of EVBA on muscle sympathetic nerve activity (MS
Externí odkaz:
https://doaj.org/article/edeed791535346549be1283a97076f5f
Autor:
Jorge Manuel, Natalia Färber, Darius A Gerlach, Karsten Heusser, Jens Jordan, Jens Tank, Florian Beissner
Publikováno v:
eLife, Vol 9 (2020)
Cardiovascular regulation is integral to life. Animal studies have identified both neural and endocrine pathways, by which the central nervous system adjusts cardiac output and peripheral vascular resistance to changing physiological demands. The out
Externí odkaz:
https://doaj.org/article/603704b53d2d44f6a5d48ee08ca9fba2
Autor:
Franca Barbic, Karsten Heusser, Maura Minonzio, Dana Shiffer, Beatrice Cairo, Jens Tank, Jens Jordan, André Diedrich, Peter Gauger, Roberto Antonio Zamuner, Alberto Porta, Raffaello Furlan
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Orthostatic intolerance commonly occurs after prolonged bed rest, thus increasing the risk of syncope and falls. Baroreflex-mediated adjustments of heart rate and sympathetic vasomotor activity (muscle sympathetic nerve activity – MSNA) are crucial
Externí odkaz:
https://doaj.org/article/0b5aa2461242423d931e3220dc013dfb
Autor:
Darius A. Gerlach, Jorge Manuel, Alex Hoff, Hendrik Kronsbein, Fabian Hoffmann, Karsten Heusser, Heimo Ehmke, André Diedrich, Jens Jordan, Jens Tank, Florian Beissner
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Introduction: Brainstem nuclei govern the arterial baroreflex, which is crucial for heart rate and blood pressure control. Yet, brainstem function is difficult to explore in living humans and is therefore mostly studied using animal models or postmor
Externí odkaz:
https://doaj.org/article/e9229e1464e7419292363db09d184821
Autor:
Karsten Heusser, Jens Tank, Julia Brinkmann, Christoph Schroeder, Marcus May, Anika Großhennig, Daniela Wenzel, André Diedrich, Fred C. G. J. Sweep, Heidrun Mehling, Friedrich C. Luft, Jens Jordan
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 1 (2016)
BackgroundSympathetic and parasympathetic influences on heart rate (HR), which are governed by baroreflex mechanisms, are integrated at the cardiac sinus node through hyperpolarization‐activated cyclic nucleotide–gated channels (HCN4). We hypothe
Externí odkaz:
https://doaj.org/article/80a2a758af5d4c1f811930e94c27e295