A Novel Method to Achieve Precision and Reproducibility in Exposure Parameters for Low-Frequency Pulsed Magnetic Fields in Human Cell Cultures

Autor: Michael Ronniger, Blanche Aguida, Christina Stacke, Yangmengfan Chen, Sabrina Ehnert, Niklas Erdmann, Georg Eschenburg, Karsten Falldorf, Marootpong Pooam, Anthony Wing, Margaret Ahmad

Publikováno v: Bioengineering, Vol 9, Iss 10, p 595 (2022)

The effects of extremely low-frequency electromagnetic field (ELF-MF) exposure on living systems have been widely studied at the fundamental level and also claimed as beneficial for the treatment of diseases for over 50 years. However, the underlying

Externí odkaz: https://doaj.org/article/bff97f1be67d40df981e4eaec588f8ff

Extremely low frequency pulsed electromagnetic fields cause antioxidative defense mechanisms in human osteoblasts via induction of •O2 − and H2O2

Autor: Sabrina Ehnert, Anne-Kristin Fentz, Anna Schreiner, Johannes Birk, Benjamin Wilbrand, Patrick Ziegler, Marie K. Reumann, Hongbo Wang, Karsten Falldorf, Andreas K. Nussler

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Abstract Recently, we identified a specific extremely low-frequency pulsed electromagnetic field (ELF-PEMF) that supports human osteoblast (hOBs) function in an ERK1/2-dependent manner, suggesting reactive oxygen species (ROS) being key regulators in

Externí odkaz: https://doaj.org/article/95c05d50719541a18a7de2d6bf37b9d1

Osteogenic Effect and Cell Signaling Activation of Extremely Low-Frequency Pulsed Electromagnetic Fields in Adipose-Derived Mesenchymal Stromal Cells

Autor: Patrina S. P. Poh, Claudine Seeliger, Marina Unger, Karsten Falldorf, Elizabeth R. Balmayor, Martijn van Griensven

Publikováno v: Stem Cells International, Vol 2018 (2018)

Extremely low-frequency pulsed electromagnetic field (ELF-PEMF) devices have been used in the clinic for the treatment of bone disorders over the past 30 years. However, the underlying mechanism of which ELF-PEMFs exert an effect on tissues at a cell

Externí odkaz: https://doaj.org/article/f51c2ee2a66f41ab8c86da60b6ace497

Co-Culture with Human Osteoblasts and Exposure to Extremely Low Frequency Pulsed Electromagnetic Fields Improve Osteogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells

Autor: Sabrina, Ehnert, Martijn, van Griensven, Marina, Unger, Hanna, Scheffler, Karsten, Falldorf, Anne-Kristin, Fentz, Claudine, Seeliger, Steffen, Schröter, Andreas K, Nussler, Elizabeth R, Balmayor

Publikováno v: International journal of molecular sciences, 19(4):994. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 19, Iss 4, p 994 (2018)
International Journal of Molecular Sciences

Human adipose-derived mesenchymal stem cells (Ad-MSCs) have been proposed as suitable option for cell-based therapies to support bone regeneration. In the bone environment, Ad-MSCs will receive stimuli from resident cells that may favor their osteoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a1b137b9432350b1f3c085c494a7a16e
https://cris.maastrichtuniversity.nl/en/publications/ff766cf4-24dd-48f6-8163-3b923ce729df

Primary human osteoblasts with reduced alkaline phosphatase and matrix mineralization baseline capacity are responsive to extremely low frequency pulsed electromagnetic field exposure — Clinical implication possible

Autor: Patrick Ziegler, Björn Gunnar Ochs, Michael Ronniger, Karsten Falldorf, Christina Stacke, Anne-Kristin Fentz, Sabrina Ehnert, Steffen Schröter, Jens Sachtleben, Thomas Freude, Andreas K. Nussler

Publikováno v: Bone Reports
Bone Reports, Vol 3, Iss C, Pp 48-56 (2015)

For many years electromagnetic fields (EMFs) have been used clinically with various settings as an exogenous stimulation method to promote fracture healing. However, underlying mechanisms of action and EMF parameters responsible for certain effects r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe1e2814eedc08cbad4f493ab40f593
http://europepmc.org/articles/PMC5365212