Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Karssen, LC"'
Autor:
Shvetsova, E, Sofronova, A, Monajemi, R, Gagalova, K, Draisma, HHM, White, SJ, Santen, GWE, Lopes, SMCDS, Heijmans, BT, Van Meurs, J, Jansen, R, Franke, L, Kielbasa, SM, Den Dunnen, JT, 't Hoen, PAC, Boomsma, DI, Pool, R, Van Dongen, J, Hottenga, JJ, Van Greevenbroek, MMJ, Da Stehouwer, C, Van der Kallen, CJH, Schalkwijk, CG, Wijmenga, C, Zhernakova, S, Tigchelaar, EF, Slagboom, PE, Beekman, M, Deelen, J, Van Heemst, D, Veldink, JH, Van den Berg, LH, Van Duijn, CM, Hofman, BA, Uitterlinden, AG, Jhamai, PM, Verbiest, M, Suchiman, HED, Verkerk, M, Van der Breggen, R, Van Rooij, J, Lakenberg, N, Mei, H, Bot, J, Zhernakova, DV, 't Hof, PV, Deelen, P, Nooren, I, Moed, M, Vermaat, M, Luijk, R, Bonder, MJ, Van Iterson, M, Van Dijk, F, Van Galen, M, Arindrarto, W, Swertz, MA, Van Zwet, EW, Isaacs, A, Francioli, LC, Menelaou, A, Pulit, SL, Palamara, PF, Elbers, CC, Neerincx, PB, Ye, K, Guryev, V, Kloosterman, WP, Abdellaoui, A, Van Leeuwen, EM, Van Oven, M, Li, M, Laros, JF, Karssen, LC, Kanterakis, A, Amin, N, Lameijer, EW, Kattenberg, M, Dijkstra, M, Byelas, H, Van Setten, J, Van Schaik, BD, Nijman, IJ, Renkens, I, Marschall, T, Schonhuth, A, Hehir-Kwa, JY, Handsaker, RE, Polak, P, Sohail, M, Vuzman, D, Hormozdiari, F, Van Enckevort, D, Koval, V, Moed, MH, Van der Velde, KJ, Rivadeneira, F, Estrada, K, Medina-Gomez, C, McCarroll, SA, De Craen, AJ, Suchiman, HE, Oostra, B, Willemsen, G, Platteel, M, Pitts, SJ, Potluri, S, Sundar, P, Cox, DR, Sunyaev, SR, Stoneking, M, De Knijff, P, Kayser, M, Li, Q, Li, Y, Du, Y, Chen, R, Cao, H, Li, N, Cao, S, Wang, J, Bovenberg, JA, Pe'er, I, Van Ommen, GJ, De Bakker, PI
Publikováno v:
European Journal of Human Genetics
European Journal of Human Genetics, 27(3), 455-465. Nature Publishing Group
European journal of human genetics, 27(3), 455-465. Nature Publishing Group
European Journal of Human Genetics, 27(3), 455-465
European Journal of Human Genetics, 27, 455-465
European Journal of Human Genetics, 27(3), 455. Nature Publishing Group
European Journal of Human Genetics, 27, 3, pp. 455-465
Shvetsova, E, 't Hoen, P A C, Boomsma, D I, Pool, R, van Dongen, J, Hottenga, J J, Willemsen, G & BIOS Consortium 2019, ' Skewed X-inactivation is common in the general female population ', European Journal of Human Genetics, vol. 27, no. 3, pp. 455-465 . https://doi.org/10.1038/s41431-018-0291-3
Shvetsova, E, Sofronova, A, Monajemi, R, Gagalova, K, Draisma, H H M, White, S J, Santen, G W E, Chuva de Sousa Lopes, S M, Heijmans, B T, van Meurs, J, Jansen, R, Franke, L, Kiełbasa, S M, den Dunnen, J T, ‘t Hoen, P A C & BIOS Consortium 2019, ' Skewed X-inactivation is common in the general female population ', European Journal of Human Genetics, vol. 27, no. 3, pp. 455-465 . https://doi.org/10.1038/s41431-018-0291-3
European Journal of Human Genetics, 27(3), 455-465. Nature Publishing Group
European journal of human genetics, 27(3), 455-465. Nature Publishing Group
European Journal of Human Genetics, 27(3), 455-465
European Journal of Human Genetics, 27, 455-465
European Journal of Human Genetics, 27(3), 455. Nature Publishing Group
European Journal of Human Genetics, 27, 3, pp. 455-465
Shvetsova, E, 't Hoen, P A C, Boomsma, D I, Pool, R, van Dongen, J, Hottenga, J J, Willemsen, G & BIOS Consortium 2019, ' Skewed X-inactivation is common in the general female population ', European Journal of Human Genetics, vol. 27, no. 3, pp. 455-465 . https://doi.org/10.1038/s41431-018-0291-3
Shvetsova, E, Sofronova, A, Monajemi, R, Gagalova, K, Draisma, H H M, White, S J, Santen, G W E, Chuva de Sousa Lopes, S M, Heijmans, B T, van Meurs, J, Jansen, R, Franke, L, Kiełbasa, S M, den Dunnen, J T, ‘t Hoen, P A C & BIOS Consortium 2019, ' Skewed X-inactivation is common in the general female population ', European Journal of Human Genetics, vol. 27, no. 3, pp. 455-465 . https://doi.org/10.1038/s41431-018-0291-3
X-inactivation is a well-established dosage compensation mechanism ensuring that X-chromosomal genes are expressed at comparable levels in males and females. Skewed X-inactivation is often explained by negative selection of one of the alleles. We dem
Autor:
Van Leeuwen, EM, Karssen, LC, Deelen, J, Isaacs, A, Medina-Gomez, C, Mbarek, H, Kanterakis, A, Trompet, S, Postmus, I, Verweij, N, Van Enckevort, DJ, Huffman, JE, White, CC, Feitosa, MF, Bartz, TM, Manichaikul, A, Joshi, PK, Peloso, GM, Deelen, P, Van Dijk, F, Willemsen, G, De Geus, EJ, Milaneschi, Y, Penninx, BWJH, Francioli, LC, Menelaou, A, Pulit, SL, Rivadeneira, F, Hofman, A, Oostra, BA, Franco, OH, Leach, IM, Beekman, M, De Craen, AJM, Uh, HW, Trochet, H, Hocking, LJ, Porteous, DJ, Sattar, N, Packard, CJ, Buckley, BM, Brody, JA, Bis, JC, Rotter, JI, Mychaleckyj, JC, Campbell, H, Duan, Q, Lange, LA, Wilson, JF, Hayward, C, Polasek, O, Vitart, V, Rudan, I, Wright, AF, Rich, SS, Psaty, BM, Borecki, IB, Kearney, PM, Stott, DJ, Cupples, LA, Jukema, JW, Van Der Harst, P, Sijbrands, EJ, Hottenga, JJ, Uitterlinden, AG, Swertz, MA, Van Ommen, GJB, De Bakker, PIW, Eline Slagboom, P, Boomsma, DI, Wijmenga, C, Van Duijn, CM, Neerincx, PBT, Elbers, CC, Palamara, PF, Peer, I, Abdellaoui, A, Kloosterman, WP, Van Oven, M, Vermaat, M, Li, M, Laros, JFJ, Stoneking, M, De Knijff, P, Kayser, M, Veldink, JH, Van Den Berg, LH, Byelas, H, Den Dunnen, JT, Dijkstra, M, Amin, N, Van Der Velde, KJ, Van Setten, J
Publikováno v:
Van Leeuwen, EM; Karssen, LC; Deelen, J; Isaacs, A; Medina-Gomez, C; Mbarek, H; et al.(2015). Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels. Nature Communications, 6. doi: 10.1038/ncomms7065. UCLA: Retrieved from: http://www.escholarship.org/uc/item/0pf7030w
© 2015 Macmillan Publishers Limited. All rights reserved. Variants associated with blood lipid levels may be population-specific. To identify low-frequency variants associated with this phenotype, population-specific reference panels may be used. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::40fe9f479300706910e75022cbf7bdca
http://www.escholarship.org/uc/item/0pf7030w
http://www.escholarship.org/uc/item/0pf7030w
Autor:
Springelkamp, H, Höhn, R, Mishra, A, Hysi, PG, Khor, CC, Loomis, SJ, Bailey, JNC, Gibson, J, Thorleifsson, G, Janssen, SF, Luo, X, Ramdas, WD, Vithana, E, Nongpiur, ME, Montgomery, GW, Xu, L, Mountain, JE, Gharahkhani, P, Lu, Y, Amin, N, Karssen, LC, Sim, KS, Van Leeuwen, EM, Iglesias, AI, Verhoeven, VJM, Hauser, MA, Loon, SC, Despriet, DDG, Nag, A, Venturini, C, Sanfilippo, PG, Schillert, A, Kang, JH, Landers, J, Jonasson, F, Cree, AJ, Van Koolwijk, LME, Rivadeneira, F, Souzeau, E, Jonsson, V, Menon, G, Mitchell, P, Wang, JJ, Rochtchina, E, Attia, J, Scott, R, Holliday, EG, Baird, PN, Xie, J, Inouye, M, Viswanathan, A, Sim, X, Weinreb, RN, De Jong, PTVM, Oostra, BA, Uitterlinden, AG, Hofman, A, Ennis, S, Thorsteinsdottir, U, Burdon, KP, Allingham, RR, Brilliant, MH, Budenz, DL, Christen, WG, Fingert, J, Friedman, DS, Gaasterland, D, Gaasterland, T, Haines, JL, Kraft, P, Lee, RK, Lichter, PR, Liu, Y
Publikováno v:
Springelkamp, H; Höhn, R; Mishra, A; Hysi, PG; Khor, CC; Loomis, SJ; et al.(2014). Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process. Nature Communications, 5. doi: 10.1038/ncomms5883. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/8tq3b2r0
© 2014 Macmillan Publishers Limited. All rights reserved. Glaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindness worldwide. Here, the International Glaucoma Genetics Consortium con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::432a7734471df3879f32c6d2d291d0b9
http://www.escholarship.org/uc/item/8tq3b2r0
http://www.escholarship.org/uc/item/8tq3b2r0
Akademický článek
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Autor:
Luciano Navarini, Angela D'Eustacchio, Giorgio Pistis, Michela Traglia, Cornelia M. van Duijn, Pio D'Adamo, Maarten Kooyman, Sara M. Willems, Cinzia Sala, Paolo Gasparini, Daniela Toniolo, Najaf Amin, Antonietta Robino, Nicola Pirastu, Lennart C. Karssen
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92065 (2014)
PLoS One (print), 9(3). Public Library of Science
PLoS ONE; Vol 9
PLoS ONE
PLoS One (print), 9(3). Public Library of Science
PLoS ONE; Vol 9
PLoS ONE
Coffee, one of the most popular beverages in the world, contains many different physiologically active compounds with a potential impact on people's health. Despite the recent attention given to the genetic basis of its consumption, very little has b
Autor:
Tsepilov YA; Laboratory of Recombination and Segregation Analysis, Institute of Cytology and Genetics, Novosibirsk 630090, Russia.; Kurchatov Genomics Center, Institute of Cytology and Genetics, Novosibirsk 630090, Russia., Elgaeva EE; Laboratory of Recombination and Segregation Analysis, Institute of Cytology and Genetics, Novosibirsk 630090, Russia.; Department of Natural Sciences, Novosibirsk State University, Novosibirsk 630090, Russia., Nostaeva AV; Department of Natural Sciences, Novosibirsk State University, Novosibirsk 630090, Russia., Compte R; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London SE1 7EH, UK., Kuznetsov IA; Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow 121205, Russia., Karssen LC; PolyOmica, 5237 PA s-Hertogenbosch, The Netherlands., Freidin MB; Department of Biology, School of Biological and Behavioural Sciences, Queen Mary University of London, London E1 4NS, UK., Suri P; Division of Rehabilitation Care Services, VA Puget Sound Health Care System, Seattle, WA 98208, USA.; Seattle Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, WA 98208, USA.; Department of Rehabilitation Medicine, University of Washington, Seattle, WA 98208, USA.; Clinical Learning, Evidence, and Research (CLEAR) Center, University of Washington, Seattle, WA 98208, USA., Williams FMK; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London SE1 7EH, UK., Aulchenko YS; Laboratory of Recombination and Segregation Analysis, Institute of Cytology and Genetics, Novosibirsk 630090, Russia.; PolyOmica, 5237 PA s-Hertogenbosch, The Netherlands.
Publikováno v:
Journal of personalized medicine [J Pers Med] 2023 Jun 10; Vol. 13 (6). Date of Electronic Publication: 2023 Jun 10.
Autor:
Sharapov SZ; Laboratory of Glycogenomics, Institute of Cytology and Genetics, Prospekt Akademika Lavrent'yeva, 10, Novosibirsk, 630090, Russia., Shadrina AS; Laboratory of Glycogenomics, Institute of Cytology and Genetics, Prospekt Akademika Lavrent'yeva, 10, Novosibirsk, 630090, Russia., Tsepilov YA; Laboratory of Theoretical and Applied Functional Genomics, Novosibirsk State University, Pirogova 1, Novosibirsk, 630090, Russia.; Laboratory of Recombination and Segregation Analysis, Institute of Cytology and Genetics, Prospekt Akademika Lavrent'yeva, 10, Novosibirsk, 630090, Russia., Elgaeva EE; Laboratory of Glycogenomics, Institute of Cytology and Genetics, Prospekt Akademika Lavrent'yeva, 10, Novosibirsk, 630090, Russia., Tiys ES; Laboratory of Glycogenomics, Institute of Cytology and Genetics, Prospekt Akademika Lavrent'yeva, 10, Novosibirsk, 630090, Russia., Feoktistova SG; Laboratory of Glycogenomics, Institute of Cytology and Genetics, Prospekt Akademika Lavrent'yeva, 10, Novosibirsk, 630090, Russia., Zaytseva OO; Genos Glycoscience Research Laboratory, Borongajska cesta 83h, 10000 Zagreb, Croatia., Vuckovic F; Genos Glycoscience Research Laboratory, Borongajska cesta 83h, 10000 Zagreb, Croatia., Cuadrat R; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam- Rehbruecke, 14558 Nuthetal, Germany., Jäger S; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam- Rehbruecke, 14558 Nuthetal, Germany.; German Center for Diabetes Research (DZD), ngolstädter Landstraβe 1, Neuherberg, 85764, Germany., Wittenbecher C; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam- Rehbruecke, 14558 Nuthetal, Germany.; German Center for Diabetes Research (DZD), ngolstädter Landstraβe 1, Neuherberg, 85764, Germany.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Karssen LC; PolyOmica, s-Hertogenbosch 5237, The Netherlands., Timofeeva M; Colon Cancer Genetics Group, Cancer Research UK Edinburgh Centre, Medical Research Council Institute of Genetics & Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh EH4 2XU, UK.; D-IAS, Danish Institute for Advanced Study, Department of Public Health, University of Southern Denmark, , J.B. Winsløws Vej 9, DK-5000 Odense C, Denmark., Tillin T; MRC Unit for Lifelong Health & Ageing University College London, Gower Street, London, WC1E 6BT, UK., Trbojević-Akmačić I; Genos Glycoscience Research Laboratory, Borongajska cesta 83h, 10000 Zagreb, Croatia., Štambuk T; Genos Glycoscience Research Laboratory, Borongajska cesta 83h, 10000 Zagreb, Croatia., Rudman N; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, 10000, Croatia., Krištić J; Genos Glycoscience Research Laboratory, Borongajska cesta 83h, 10000 Zagreb, Croatia., Šimunović J; Genos Glycoscience Research Laboratory, Borongajska cesta 83h, 10000 Zagreb, Croatia., Momčilović A; Genos Glycoscience Research Laboratory, Borongajska cesta 83h, 10000 Zagreb, Croatia., Vilaj M; Genos Glycoscience Research Laboratory, Borongajska cesta 83h, 10000 Zagreb, Croatia., Jurić J; Genos Glycoscience Research Laboratory, Borongajska cesta 83h, 10000 Zagreb, Croatia., Slana A; Genos Glycoscience Research Laboratory, Borongajska cesta 83h, 10000 Zagreb, Croatia., Gudelj I; Genos Glycoscience Research Laboratory, Borongajska cesta 83h, 10000 Zagreb, Croatia., Klarić T; Genos Glycoscience Research Laboratory, Borongajska cesta 83h, 10000 Zagreb, Croatia., Puljak L; Catholic University of Croatia, Ilica, 242 Zagreb, 10000, Croatia., Skelin A; Genos Glycoscience Research Laboratory, Borongajska cesta 83h, 10000 Zagreb, Croatia.; St. Catherine Specialty Hospital, 10000 Zagreb & 49210, Zabok, Croatia., Kadić AJ; University Hospital Center Split, Department of Pediatrics, Spinčićeva ul. 1, Split, 21000, Croatia., Van Zundert J; Department of Anesthesiology and Multidisciplinary Paincentre, ZOL, Genk/Lanaken, Belgium.; Department of Anesthesiology and Pain Medicine, Maastricht University Medical Centre, P. Debyelaan 25, Maastricht, 6229 HX, The Netherlands., Chaturvedi N; MRC Unit for Lifelong Health & Ageing University College London, Gower Street, London, WC1E 6BT, UK., Campbell H; Colon Cancer Genetics Group, Cancer Research UK Edinburgh Centre, Medical Research Council Institute of Genetics & Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh EH4 2XU, UK.; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh EH8 9AG, UK., Dunlop M; Colon Cancer Genetics Group, Cancer Research UK Edinburgh Centre, Medical Research Council Institute of Genetics & Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh EH4 2XU, UK., Farrington SM; Colon Cancer Genetics Group, Cancer Research UK Edinburgh Centre, Medical Research Council Institute of Genetics & Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh EH4 2XU, UK., Doherty M; Institute of Technology Sligo, Department of Life Sciences, Ash Ln, Bellanode, Sligo, F91 YW50, Ireland.; National Institute for Bioprocessing Research & Training, 24 Foster's Ave, Belfield, Blackrock, Co.,Dublin, A94 X099, Ireland., Dagostino C; Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, Italy., Gieger C; Institute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Centre Munich, German Research Center for Environmental Health, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany., Allegri M; Pain Therapy Department Policlinico Monza Hospital, 20090 Monza, Italy., Williams F; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, St Thomas' Campus, Lambeth Palace Road, London SE1 7EH, UK., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam- Rehbruecke, 14558 Nuthetal, Germany.; German Center for Diabetes Research (DZD), ngolstädter Landstraβe 1, Neuherberg, 85764, Germany.; Institute of Nutrition Science, University of Potsdam, 14558 Nuthetal, Germany., Lauc G; Genos Glycoscience Research Laboratory, Borongajska cesta 83h, 10000 Zagreb, Croatia., Aulchenko YS; Laboratory of Glycogenomics, Institute of Cytology and Genetics, Prospekt Akademika Lavrent'yeva, 10, Novosibirsk, 630090, Russia.
Publikováno v:
Glycobiology [Glycobiology] 2021 Feb 09; Vol. 31 (2), pp. 82-88.
Autor:
Shashkova TI; Theoretical and Applied Functional Genomics Laboratory, Novosibirsk State University, Novosibirsk 630090, Russia.; Department of Molecular and Biological physics, Moscow Institute of Physics and Technology (State University), Moscow 117303, Russia., Pakhomov ED; Theoretical and Applied Functional Genomics Laboratory, Novosibirsk State University, Novosibirsk 630090, Russia., Gorev DD; Theoretical and Applied Functional Genomics Laboratory, Novosibirsk State University, Novosibirsk 630090, Russia.; Department of Algorithms and Programming Technologies, Moscow Institute of Physics and Technology (State University), Moscow 117303, Russia., Karssen LC; PolyKnomics, 's-Hertogenbosch 5237 PA, Netherlands., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh EH8 9AG, Scotland, UK., Aulchenko YS; Theoretical and Applied Functional Genomics Laboratory, Novosibirsk State University, Novosibirsk 630090, Russia.; PolyKnomics, 's-Hertogenbosch 5237 PA, Netherlands.
Publikováno v:
Nucleic acids research [Nucleic Acids Res] 2021 Jan 08; Vol. 49 (D1), pp. D1347-D1350.
Autor:
Shashkova TI; Laboratory of Theoretical and Applied Functional Genomics, Novosibirsk State University, Novosibirsk, Russia., Gorev DD; Laboratory of Theoretical and Applied Functional Genomics, Novosibirsk State University, Novosibirsk, Russia., Pakhomov ED; Laboratory of Theoretical and Applied Functional Genomics, Novosibirsk State University, Novosibirsk, Russia PolyKnomics BV, 's-Hertogenbosch, The Netherlands., Shadrina AS; Laboratory of Theoretical and Applied Functional Genomics, Novosibirsk State University, Novosibirsk, Russia., Sharapov SZ; Laboratory of Theoretical and Applied Functional Genomics, Novosibirsk State University, Novosibirsk, Russia., Tsepilov YA; Laboratory of Theoretical and Applied Functional Genomics, Novosibirsk State University, Novosibirsk, Russia., Karssen LC; PolyKnomics BV, 's-Hertogenbosch, The Netherlands., Aulchenko YS; Laboratory of Theoretical and Applied Functional Genomics, Novosibirsk State University, Novosibirsk, Russia.
Publikováno v:
Vavilovskii zhurnal genetiki i selektsii [Vavilovskii Zhurnal Genet Selektsii] 2020 Dec; Vol. 24 (8), pp. 876-884.
Autor:
Freidin MB; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, United Kingdom., Tsepilov YA; Laboratory of Theoretical and Applied Functional Genomics, Faculty of Natural Sciences, Novosibirsk State University, Novosibirsk, Russia.; Laboratory of Recombination and Segregation Analysis, Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia.; PolyOmica, 's-Hertogenbosch, the Netherlands., Palmer M; Department of Medical Genetics, University of Washington, Seattle, United States., Karssen LC; PolyOmica, 's-Hertogenbosch, the Netherlands., Suri P; Seattle Epidemiologic Research and Information Center (ERIC), Veterans Affairs Office of Research and Development, Seattle, United States.; Rehabilitation Care Services, VA Puget Sound Healthcare System, Seattle, United States.; Department of Rehabilitation Medicine, University of Washington, Seattle, United States., Aulchenko YS; PolyOmica, 's-Hertogenbosch, the Netherlands., Williams FMK; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, United Kingdom.
Publikováno v:
Pain [Pain] 2019 Jun; Vol. 160 (6), pp. 1361-1373.