Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Karson, S"'
Autor:
Miao, Jinmin a, 1, Lin, Jianping a, 1, Dong, Jiajun a, 1, Amarasinghe, Ovini a, Mason, Emily R. b, Chu, Shaoyou b, Qu, Zihan c, Cullers, Clayton C. c, Putt, Karson S. d, Zhang, Zhong-Yin a, c, d, ⁎
Publikováno v:
In Bioorganic & Medicinal Chemistry 15 November 2024 114
Autor:
Ramya Visvanathan, Tadanobu Utsuki, Daniel E. Beck, Emma Lendy, Kuai-lin Sun, Yinghui Liu, Kirk W. Hering, Andrew Mesecar, Zhong-Yin Zhang, Karson S. Putt
Publikováno v:
SLAS Discovery, Vol 28, Iss 4, Pp 170-179 (2023)
A rare coding variant in PLCγ2 (P522R) expressed in microglia induces a mild activation of enzymatic activity when compared to wild-type. This mutation is reported to be protective against the cognitive decline associated with late-onset Alzheimer's
Externí odkaz:
https://doaj.org/article/2d760758ae3a4d61921580a59ddd5056
Autor:
Ramya Visvanathan, Tadanobu Utsuki, Daniel E Beck, W Brent Clayton, Emma Lendy, Kuai-Lin Sun, Yinghui Liu, Kirk W Hering, Andrew Mesecar, Zhong-Yin Zhang, Karson S Putt
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0299541 (2024)
The activities of the phospholipase C gamma (PLCγ) 1 and 2 enzymes are essential for numerous cellular processes. Unsurprisingly, dysregulation of PLCγ1 or PLCγ2 activity is associated with multiple maladies including immune disorders, cancers, an
Externí odkaz:
https://doaj.org/article/07330adcb09c40d7bd2c75877bb72103
Autor:
Visvanathan, Ramya a, b, e, Utsuki, Tadanobu a, b, Beck, Daniel E. a, b, Lendy, Emma b, c, Sun, Kuai-lin d, Liu, Yinghui d, Hering, Kirk W. d, Mesecar, Andrew b, c, Zhang, Zhong-Yin a, b, e, Putt, Karson S. a, b, ⁎
Publikováno v:
In SLAS Discovery June 2023 28(4):170-179
Publikováno v:
In Life Sciences in Space Research November 2022 35:88-104
Publikováno v:
In Biophysical Journal 3 November 2020 119(9):1749-1759
Akademický článek
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Autor:
Weichuan Luo, John V. Napoleon, Fenghua Zhang, Yong Gu Lee, Bingbing Wang, Karson S. Putt, Philip S. Low
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Although CAR T cell therapies have proven to be effective in treating hematopoietic cancers, their abilities to regress solid tumors have been less encouraging. Mechanisms to explain these disparities have focused primarily on differences in cancer c
Externí odkaz:
https://doaj.org/article/ee38390f311143a2964ec9990eb61239
Publikováno v:
In Blood Cells, Molecules and Diseases July 2019 77:61-66
Autor:
Yong Gu Lee, Haiyan Chu, Yingjuan Lu, Christopher P. Leamon, Madduri Srinivasarao, Karson S. Putt, Philip S. Low
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Chimeric antigen receptor (CAR) T cell anti-cancer therapies might result in toxic side effects. Here the authors present a strategy based on the modulation of CAR T cells via administration of a bispecific adapter that target them to cancer cells, r
Externí odkaz:
https://doaj.org/article/553694276e0c432681cac75ecb3328c9