Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Karri Paavonen"'
Autor:
Birgit Steckel-Hamann, Loizos Nicolaou, Karri Paavonen, Aino Soro-Paavonen, Daniel Gordin, Valma Harjutsalo, Veikko A. Koivisto, Markku Saraheimo, Jaana Tuomikangas, Per-Henrik Groop, Imre Pavo, Carol Forsblom
Publikováno v:
Acta Diabetologica
Aims Insulin possesses both vasodilatory and sympathomimetic activities. The aim was to examine the relationship between changes in insulin exposure and arterial stiffness in type 2 diabetes (T2D). Methods Patients with T2D with (n = 22) or without (
Autor:
Teruhiko Sato, Marc G. Achen, Julie Rothacker, Natalia Davydova, Edouard C. Nice, Karri Paavonen, Tara Karnezis, Sally Roufail, You-Fang Zhang, Nicole C. Harris, Sophie Paquet-Fifield, Steven A. Stacker
Publikováno v:
Journal of Biological Chemistry. 288:8176-8186
VEGF-D is an angiogenic and lymphangiogenic glycoprotein that can be proteolytically processed generating various forms differing in subunit composition due to the presence or absence of N- and C-terminal propeptides. These propeptides flank the cent
Autor:
Rachael Inder, Tara Karnezis, G. Bruce Mann, Marc G. Achen, Ramin Shayan, Mark W. Ashton, Steven A. Stacker, Carol Caesar, G. Ian Taylor, Karri Paavonen
Publikováno v:
Clinical & Experimental Metastasis. 30:345-356
Tumor metastasis to lymph nodes is a key indicator of patient survival, and is enhanced by the neo-lymphatics induced by tumor-secreted VEGF-C or VEGF-D, acting via VEGFR-3 signalling. These targets constitute important avenues for anti-metastatic tr
Autor:
Imre Pavo, Carol Forsblom, Francois Vandenhende, Veikko A. Koivisto, Per-Henrik Groop, Jaana Tuomikangas, Birgit Steckel-Hamann, Daniel Gordin, Aino Soro-Paavonen, Markku Saraheimo, Loizos Nicolaou, Karri Paavonen
Publikováno v:
The Journal of clinical endocrinology and metabolism. 101(3)
Context: Patients with type 2 diabetes (T2D) are at an increased risk of cardiovascular disease. Objective: The objective of the study was to determine whether postprandial hyperglycemia affects arterial function in T2D. Design: Asingle-center, open-
Autor:
Karin Jandeleit-Dahm, David Barit, Audrey Koitka, Jiaze Li, Josephine M. Forbes, Karri Paavonen, Merlin C. Thomas, Aino Soro-Paavonen, Peter P. Nawroth, Brian G. Drew, Anna M.D. Watson, Mark E. Cooper, Graeme I. Lancaster, Melinda T. Coughlan, Anna C. Calkin, Angelika Bierhaus
Publikováno v:
Diabetes
OBJECTIVE—Activation of the receptor for advanced glycation end products (RAGE) in diabetic vasculature is considered to be a key mediator of atherogenesis. This study examines the effects of deletion of RAGE on the development of atherosclerosis i
Autor:
Julie Rothacker, Kenneth W. Harder, Edouard C. Nice, Tara Karnezis, Bradley McColl, Margaret L. Hibbs, Steven A. Stacker, Peter Rogers, Karri Paavonen, Marc G. Achen, Natalia Davydova, Kari Alitalo, Sally Roufail, Nicole C. Harris
Publikováno v:
The FASEB Journal. 21:1088-1098
Vascular endothelial growth factor (VEGF)-D is a secreted glycoprotein that induces angiogenesis and lymphangiogenesis. It consists of a central domain, containing binding sites for VEGF receptor-2 (VEGFR-2) and VEGFR-3, and N- and C-terminal propept
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 174:326-330
In mice, vascular endothelial growth factor-C (VEGF-C) plays an important role in development of the lymphatic system and in pathogenesis of pulmonary inflammation. Its role in development of the lymphatic system in human lung and in lung injury in n
Publikováno v:
Cardiovascular Research. 65:550-563
The discovery of the vascular endothelial growth factor (VEGF) family members VEGF, VEGF-B, placental growth factor (PlGF), VEGF-C and VEGF-D and their receptors VEGFR-1, -2 and -3 has provided tools for studying the vascular system in development as
Autor:
Marko Uutela, Kari Alitalo, Helge Wiig, Maria Wirzenius, Karri Paavonen, Terhi Karpanen, Ulf Eriksson, Marja Lohela, Yulong He, Katri Pajusola, Petri Salven, Iiro Rajantie
Publikováno v:
Blood. 104:3198-3204
Platelet-derived growth factor-D (PDGF-D) is a recently characterized member of the PDGF family with unknown in vivo functions. We investigated the effects of PDGF-D in transgenic mice by expressing it in basal epidermal cells and then analyzed skin
Publikováno v:
Molecular Biology of the Cell. 15:4226-4233
The Bmx gene, a member of the Tec family of nonreceptor protein tyrosine kinases, is expressed in arterial endothelium and in certain hematopoietic and epithelial cells. Previous in vitro studies have implicated Bmx signaling in cell migration and su