Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Karri A. Meleo"'
Autor:
Ilona Tretyak, Jessica A. Bertout, Andy Keener, Korashon L. Watts, Sarah Gillings, Karri A. Meleo, Megan N. Breit, Alicia Moreno-Gonzalez, Jason Frazier, Sally Ditzler, Kevin Choy, Chelsea D. Tripp, Derek Thirstrup, Joey R. Casalini, Ravi K. Amaravadi, James A. Perry, Richard A. Klinghoffer, Emily Beirne, Vanessa Rizzo, Marc Grenley, William S. Kerwin, Chamisa L. Herrera, James M. Olson
Publikováno v:
Cancer research. 77(11)
The vision of a precision medicine–guided approach to novel cancer drug development is challenged by high intratumor heterogeneity and interpatient diversity. This complexity is rarely modeled accurately during preclinical drug development, hamperi
Autor:
Richard A. Klinghoffer, Joseph Casalini, Emily J. Girard, Michael Carleton, Kyle Pedro, Thomas L. Deckwerth, Shelli M. Morris, Ilona Tretyak, Andrew D. Strand, Emily Beirne, James M. Olson, Sheng You, Derek Thirstrup, Oliver W. Press, Sally Ditzler, Korashon L. Watts, William S. Kerwin, Jason Frazier, Alicia Moreno-Gonzalez, Rajesh Chopra, Jessica A. Bertout, Joyoti Dey, Mandana Veiseh, Beryl A. Hatton, Ellen Filvaroff, Marc Grenley, Karri A. Meleo, S. Bahram Bahrami
A fundamental problem in cancer drug development is that antitumor efficacy in preclinical cancer models does not translate faithfully to patient outcomes. Much of early cancer drug discovery is performed under in vitro conditions in cell-based model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036e0944789fee2391dea23e9e214e73
https://europepmc.org/articles/PMC4770902/
https://europepmc.org/articles/PMC4770902/