Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts

Autor: Seibert, TM, Fan, CC, Wang, Yan, Zuber, W, Karunamuni, R, Parsons, JK, Eeles, RA, Easton, DF, Kote-Jarai, Z, Al Olama, Ali Amin, Garcia, SB, Muir, K, Gronberg, Henrik, Wiklund, Fredrik, Aly, Markus, Schleutker, Johanna, Sipeki, C, Tammela, TM, Nordestgaard, BG, Nielsen, SF, Weischer, Maren, Bisbjerg, R, Røder, MA, Iversen, P, Key, TJ, Travis, RC, Neal, DE, Donovan, JL, Hamdy, FC, Pharaoa, P, Pashayan, Nora, Khaw, KT, Maier, C., Vogel, Walther, Luedeke, M, Herkommer, K, Kibel, AS, Cybulski, C, Vokolorzcyk, D, Klusniak, W, Cannon-Albright, D, Brenner, H., Cuk, K, Saum, KU, Park, JY, Sellers, TA, Slavov, C, Kaneva, R, Mitev, V, Batra, J, Clements, JA, Spurdle, A, Teixeira, MR, Paulo, P, Maia, S, Phanda, H, Michael, A, Kierzek, A, Karow, DS, Mills, Ian Geoffrey, Andreassen, Ole Andreas, Dale, AM

Publikováno v: Seibert, TM Fan, CC Wang, Yan Zuber, W Karunamuni, R Parsons, JK Eeles, RA Easton, DF Kote-Jarai, Z Al Olama, Ali Amin Garcia, SB Muir, K Gronberg, Henrik Wiklund, Fredrik Aly, Markus Schleutker, Johanna Sipeki, C Tammela, TM Nordestgaard, BG Nielsen, SF Weischer, Maren Bisbjerg, R Røder, MA Iversen, P Key, TJ Travis, RC Neal, DE Donovan, JL Hamdy, FC Pharaoa, P Pashayan, Nora Khaw, KT Maier, C. Vogel, Walther Luedeke, M Herkommer, K Kibel, AS Cybulski, C Vokolorzcyk, D Klusniak, W Cannon-Albright, D Brenner, H. Cuk, K Saum, KU Park, JY Sellers, TA Slavov, C Kaneva, R Mitev, V Batra, J Clements, JA Spurdle, A Teixeira, MR Paulo, P Maia, S Phanda, H Michael, A Kierzek, A Karow, DS Mills, Ian Geoffrey Andreassen, Ole Andreas Dale, AM . Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts. BMJ Open. 2018, 360
BMJ Open

Externí odkaz: http://hdl.handle.net/10852/64169
https://www.duo.uio.no/bitstream/handle/10852/64169/4/bmj.j5757.full.pdf

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A Multicompartmental Diffusion Model for Improved Assessment of Whole-Body Diffusion-weighted Imaging Data and Evaluation of Prostate Cancer Bone Metastases.

Autor: Conlin CC; From the Departments of Radiology (C.C.C., A.E.R.S., J.M.K., R.R.P., D.S.K., T.M.S., M.E.H., A.M.D.), Radiation Medicine and Applied Sciences (C.H.F., L.A.D., T.M.S.), and Neurosciences (A.M.D.), UC San Diego School of Medicine, 9452 Medical Center Dr, 4W 503, La Jolla, CA 92037; Human Longevity, Inc, San Diego, Calif (D.S.K.); CorTechs Labs, Inc, San Diego, Calif (N.S.W.); Department of Bioengineering, UC San Diego Jacobs School of Engineering, La Jolla, Calif (T.M.S.); and Halıcıoğlu Data Science Institute, UC San Diego, La Jolla, Calif (A.M.D.)., Feng CH; From the Departments of Radiology (C.C.C., A.E.R.S., J.M.K., R.R.P., D.S.K., T.M.S., M.E.H., A.M.D.), Radiation Medicine and Applied Sciences (C.H.F., L.A.D., T.M.S.), and Neurosciences (A.M.D.), UC San Diego School of Medicine, 9452 Medical Center Dr, 4W 503, La Jolla, CA 92037; Human Longevity, Inc, San Diego, Calif (D.S.K.); CorTechs Labs, Inc, San Diego, Calif (N.S.W.); Department of Bioengineering, UC San Diego Jacobs School of Engineering, La Jolla, Calif (T.M.S.); and Halıcıoğlu Data Science Institute, UC San Diego, La Jolla, Calif (A.M.D.)., Digma LA; From the Departments of Radiology (C.C.C., A.E.R.S., J.M.K., R.R.P., D.S.K., T.M.S., M.E.H., A.M.D.), Radiation Medicine and Applied Sciences (C.H.F., L.A.D., T.M.S.), and Neurosciences (A.M.D.), UC San Diego School of Medicine, 9452 Medical Center Dr, 4W 503, La Jolla, CA 92037; Human Longevity, Inc, San Diego, Calif (D.S.K.); CorTechs Labs, Inc, San Diego, Calif (N.S.W.); Department of Bioengineering, UC San Diego Jacobs School of Engineering, La Jolla, Calif (T.M.S.); and Halıcıoğlu Data Science Institute, UC San Diego, La Jolla, Calif (A.M.D.)., Rodríguez-Soto AE; From the Departments of Radiology (C.C.C., A.E.R.S., J.M.K., R.R.P., D.S.K., T.M.S., M.E.H., A.M.D.), Radiation Medicine and Applied Sciences (C.H.F., L.A.D., T.M.S.), and Neurosciences (A.M.D.), UC San Diego School of Medicine, 9452 Medical Center Dr, 4W 503, La Jolla, CA 92037; Human Longevity, Inc, San Diego, Calif (D.S.K.); CorTechs Labs, Inc, San Diego, Calif (N.S.W.); Department of Bioengineering, UC San Diego Jacobs School of Engineering, La Jolla, Calif (T.M.S.); and Halıcıoğlu Data Science Institute, UC San Diego, La Jolla, Calif (A.M.D.)., Kuperman JM; From the Departments of Radiology (C.C.C., A.E.R.S., J.M.K., R.R.P., D.S.K., T.M.S., M.E.H., A.M.D.), Radiation Medicine and Applied Sciences (C.H.F., L.A.D., T.M.S.), and Neurosciences (A.M.D.), UC San Diego School of Medicine, 9452 Medical Center Dr, 4W 503, La Jolla, CA 92037; Human Longevity, Inc, San Diego, Calif (D.S.K.); CorTechs Labs, Inc, San Diego, Calif (N.S.W.); Department of Bioengineering, UC San Diego Jacobs School of Engineering, La Jolla, Calif (T.M.S.); and Halıcıoğlu Data Science Institute, UC San Diego, La Jolla, Calif (A.M.D.)., Rakow-Penner R; From the Departments of Radiology (C.C.C., A.E.R.S., J.M.K., R.R.P., D.S.K., T.M.S., M.E.H., A.M.D.), Radiation Medicine and Applied Sciences (C.H.F., L.A.D., T.M.S.), and Neurosciences (A.M.D.), UC San Diego School of Medicine, 9452 Medical Center Dr, 4W 503, La Jolla, CA 92037; Human Longevity, Inc, San Diego, Calif (D.S.K.); CorTechs Labs, Inc, San Diego, Calif (N.S.W.); Department of Bioengineering, UC San Diego Jacobs School of Engineering, La Jolla, Calif (T.M.S.); and Halıcıoğlu Data Science Institute, UC San Diego, La Jolla, Calif (A.M.D.)., Karow DS; From the Departments of Radiology (C.C.C., A.E.R.S., J.M.K., R.R.P., D.S.K., T.M.S., M.E.H., A.M.D.), Radiation Medicine and Applied Sciences (C.H.F., L.A.D., T.M.S.), and Neurosciences (A.M.D.), UC San Diego School of Medicine, 9452 Medical Center Dr, 4W 503, La Jolla, CA 92037; Human Longevity, Inc, San Diego, Calif (D.S.K.); CorTechs Labs, Inc, San Diego, Calif (N.S.W.); Department of Bioengineering, UC San Diego Jacobs School of Engineering, La Jolla, Calif (T.M.S.); and Halıcıoğlu Data Science Institute, UC San Diego, La Jolla, Calif (A.M.D.)., White NS; From the Departments of Radiology (C.C.C., A.E.R.S., J.M.K., R.R.P., D.S.K., T.M.S., M.E.H., A.M.D.), Radiation Medicine and Applied Sciences (C.H.F., L.A.D., T.M.S.), and Neurosciences (A.M.D.), UC San Diego School of Medicine, 9452 Medical Center Dr, 4W 503, La Jolla, CA 92037; Human Longevity, Inc, San Diego, Calif (D.S.K.); CorTechs Labs, Inc, San Diego, Calif (N.S.W.); Department of Bioengineering, UC San Diego Jacobs School of Engineering, La Jolla, Calif (T.M.S.); and Halıcıoğlu Data Science Institute, UC San Diego, La Jolla, Calif (A.M.D.)., Seibert TM; From the Departments of Radiology (C.C.C., A.E.R.S., J.M.K., R.R.P., D.S.K., T.M.S., M.E.H., A.M.D.), Radiation Medicine and Applied Sciences (C.H.F., L.A.D., T.M.S.), and Neurosciences (A.M.D.), UC San Diego School of Medicine, 9452 Medical Center Dr, 4W 503, La Jolla, CA 92037; Human Longevity, Inc, San Diego, Calif (D.S.K.); CorTechs Labs, Inc, San Diego, Calif (N.S.W.); Department of Bioengineering, UC San Diego Jacobs School of Engineering, La Jolla, Calif (T.M.S.); and Halıcıoğlu Data Science Institute, UC San Diego, La Jolla, Calif (A.M.D.)., Hahn ME; From the Departments of Radiology (C.C.C., A.E.R.S., J.M.K., R.R.P., D.S.K., T.M.S., M.E.H., A.M.D.), Radiation Medicine and Applied Sciences (C.H.F., L.A.D., T.M.S.), and Neurosciences (A.M.D.), UC San Diego School of Medicine, 9452 Medical Center Dr, 4W 503, La Jolla, CA 92037; Human Longevity, Inc, San Diego, Calif (D.S.K.); CorTechs Labs, Inc, San Diego, Calif (N.S.W.); Department of Bioengineering, UC San Diego Jacobs School of Engineering, La Jolla, Calif (T.M.S.); and Halıcıoğlu Data Science Institute, UC San Diego, La Jolla, Calif (A.M.D.)., Dale AM; From the Departments of Radiology (C.C.C., A.E.R.S., J.M.K., R.R.P., D.S.K., T.M.S., M.E.H., A.M.D.), Radiation Medicine and Applied Sciences (C.H.F., L.A.D., T.M.S.), and Neurosciences (A.M.D.), UC San Diego School of Medicine, 9452 Medical Center Dr, 4W 503, La Jolla, CA 92037; Human Longevity, Inc, San Diego, Calif (D.S.K.); CorTechs Labs, Inc, San Diego, Calif (N.S.W.); Department of Bioengineering, UC San Diego Jacobs School of Engineering, La Jolla, Calif (T.M.S.); and Halıcıoğlu Data Science Institute, UC San Diego, La Jolla, Calif (A.M.D.).

Publikováno v: Radiology. Imaging cancer [Radiol Imaging Cancer] 2023 Jan; Vol. 5 (1), pp. e210115.

An unsupervised learning approach to identify novel signatures of health and disease from multimodal data.

Autor: Shomorony I; Human Longevity, Inc., San Diego, CA, 92121, USA.; Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61820, USA., Cirulli ET; Human Longevity, Inc., San Diego, CA, 92121, USA., Huang L; Human Longevity, Inc., San Diego, CA, 92121, USA., Napier LA; Human Longevity, Inc., San Diego, CA, 92121, USA., Heister RR; Human Longevity, Inc., San Diego, CA, 92121, USA., Hicks M; Human Longevity, Inc., San Diego, CA, 92121, USA., Cohen IV; Human Longevity, Inc., San Diego, CA, 92121, USA., Yu HC; Human Longevity, Inc., San Diego, CA, 92121, USA., Swisher CL; Human Longevity, Inc., San Diego, CA, 92121, USA., Schenker-Ahmed NM; Human Longevity, Inc., San Diego, CA, 92121, USA., Li W; Human Longevity, Inc., San Diego, CA, 92121, USA.; J. Craig Venter Institute, La Jolla, CA, 92037, USA., Nelson KE; Human Longevity, Inc., San Diego, CA, 92121, USA.; J. Craig Venter Institute, La Jolla, CA, 92037, USA., Brar P; Human Longevity, Inc., San Diego, CA, 92121, USA.; J. Craig Venter Institute, La Jolla, CA, 92037, USA., Kahn AM; Human Longevity, Inc., San Diego, CA, 92121, USA.; Division of Cardiovascular Medicine, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Caskey CT; Human Longevity, Inc., San Diego, CA, 92121, USA.; Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA., Venter JC; Human Longevity, Inc., San Diego, CA, 92121, USA.; J. Craig Venter Institute, La Jolla, CA, 92037, USA., Karow DS; Human Longevity, Inc., San Diego, CA, 92121, USA., Kirkness EF; Human Longevity, Inc., San Diego, CA, 92121, USA.; J. Craig Venter Institute, La Jolla, CA, 92037, USA., Shah N; Human Longevity, Inc., San Diego, CA, 92121, USA. naishas@gmail.com.; J. Craig Venter Institute, La Jolla, CA, 92037, USA. naishas@gmail.com.

Publikováno v: Genome medicine [Genome Med] 2020 Jan 10; Vol. 12 (1), pp. 7. Date of Electronic Publication: 2020 Jan 10.