Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Karouzakis, P."'
Publikováno v:
Globalization and Health, Vol 20, Iss 1, Pp 1-11 (2024)
Abstract Background and methods Competition regulation has a strong influence on the relative market power of firms. As such, competition regulation can complement industry-specific measures designed to address harms associated with excessive market
Externí odkaz:
https://doaj.org/article/f2a0b36fdd9f40d7a39e011c6f5d2570
The importance of unspanned macroeconomic variables for Dynamic Term Structure Models has been intensively discussed in the literature. To our best knowledge the earlier studies considered only linear interactions between the economy and the real-wor
Externí odkaz:
http://arxiv.org/abs/2305.11001
We explore the importance of information hidden from the yield curve and assess how valuable the unspanned risks are to a real-time Bayesian investor seeking to forecast excess bond returns and maximise her utility. We propose a novel class of arbitr
Externí odkaz:
http://arxiv.org/abs/2205.00098
We explore the statistical and economic importance of restrictions on the dynamics of risk compensation from the perspective of a real-time Bayesian learner who predicts bond excess returns using dynamic term structure models (DTSMs). The question on
Externí odkaz:
http://arxiv.org/abs/2204.10658
Akademický článek
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Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis
Autor:
Emmanuel Karouzakis, Karim Raza, Christoph Kolling, Christopher D. Buckley, Steffen Gay, Andrew Filer, Caroline Ospelt
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)
Abstract DNA methylation is an important epigenetic modification that is known to be altered in rheumatoid arthritis synovial fibroblasts (RASF). Here, we compared the status of promoter DNA methylation of SF from patients with very early RA with SF
Externí odkaz:
https://doaj.org/article/66ae989f317c47c48a1eb0beaea82838
Autor:
Mojca Frank-Bertoncelj, Michelle Trenkmann, Kerstin Klein, Emmanuel Karouzakis, Hubert Rehrauer, Anna Bratus, Christoph Kolling, Maria Armaka, Andrew Filer, Beat A. Michel, Renate E. Gay, Christopher D. Buckley, George Kollias, Steffen Gay, Caroline Ospelt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Arthritis affects different joints variably despite systemic inflammatory cues. Here the authors show anatomical differences in the transcriptome, epigenome and function of synovial fibroblasts that might affect susceptibility to site-specific joint
Externí odkaz:
https://doaj.org/article/316497af76764c49b96164a02648272a
Autor:
Emmanuel Karouzakis, Janine Hähnlein, Cristoforo Grasso, Johanna F. Semmelink, Paul P. Tak, Danielle M. Gerlag, Steffen Gay, Caroline Ospelt, Lisa G. M. van Baarsen
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Rheumatoid arthritis (RA) is a progressive, destructive autoimmune arthritis. Break of tolerance and formation of autoantibodies occur years before arthritis. Adaptive immunity is initiated in lymphoid tissue where lymph node stromal cells (LNSCs) pl
Externí odkaz:
https://doaj.org/article/9e61f43083b340f5b1c8ae942a338d22
Autor:
Michel Neidhart, Agnieszka Pajak, Katerina Laskari, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea, Esther Lutgens, Eric S. G. Stroes, Adrian Ciurea, Oliver Distler, Mariam Grigorian, Emmanuel Karouzakis
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Objectives: Most DAMPs in inflammatory diseases are TLR2- and TLR4-ligands and according to the current concept, repeated stimuli would result in tolerance. Aims of the study were to verify this assumption, to investigate whether epigenetic effectors
Externí odkaz:
https://doaj.org/article/25f07bc300ff47c58ee0c17dc100b68c
Autor:
Fangfang Sun, Irene Abreu-Rodriguez, Shuang Ye, Steffen Gay, Oliver Distler, Michel Neidhart, Emmanuel Karouzakis
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218551 (2019)
Activation of macrophages and overexpression of TNFα is associated with the pathogenesis of chronic inflammatory diseases. However, the mechanisms leading to TNFα overexpression are still unknown. 5-methylocytosine (5-mC) is an epigenetic modificat
Externí odkaz:
https://doaj.org/article/aa8ac82f330d494089f4296dc07fe641