Multidisciplinary analysis of biological effects of novel analogs of the neurosteroid allopregnanolone : evidence for a proliferative, neurogenic and neuroprotective action

Autor: Karout, Mona

Ce travail de thèse a permis de caractériser avec succès des analogues structuraux de l´allopregnanolone présentant pour certains d'entre eux des effets bénéfiques et des avantages par rapport à la molécule de référence. En particulier, l'

Externí odkaz: http://www.theses.fr/2015STRAJ056/document

Quantitative trait locus mapping identifies a locus linked to striatal dopamine and points to collagen IV alpha-6 chain as a novel regulator of striatal axonal branching in mice

Autor: Thomas, Melanie, Gui, Yujuan, Garcia, Pierre, Karout, Mona, Gomez Ramos, Borja, Jaeger, Christian, Michelucci, Alessandro, Gaigneaux, Anthoula, Kollmus, Heike, Centeno, Arthur, Schughart, Klaus, Balling, Rudi, Mittelbronn, Michel, Nadeau, Joseph H., Sauter, Thomas, Williams, Robert W., Sinkkonen, Lasse, Buttini, Manuel

Dopaminergic neurons (DA neurons) are controlled by multiple factors, many involved in neurological disease. Parkinson's disease motor symptoms are caused by the demise of nigral DA neurons, leading to loss of striatal dopamine (DA). Here, we measure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2658::6feaf740bf1a9a712ab680ec1b88a66a
http://orbilu.uni.lu/handle/10993/48896

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Opposite Phenotypes of Muscle Strength and Locomotor Function in Mouse Models of Partial Trisomy and Monosomy 21 for the Proximal Hspa13-App Region

Autor: Brault Véronique, Duchon Arnaud, Romestaing Caroline, Sahun Ignasi, Pothion Stéphanie, Karout Mona, Borel Christelle, Dembele Doulaye, Bizot Jean Charles, Messaddeq Nadia

Publikováno v: PLoS Genetics
PLoS Genetics, Public Library of Science, 2015, 11 : e1005062. ((3)), pp.1-27. ⟨10.1371/journal.pgen.1005062⟩
PLOS Genetics, Vol. 11, No 3 (2015) P. e1005062
PLoS Genetics, Vol 11, Iss 3, p e1005062 (2015)
PLoS Genetics, Public Library of Science, 2015, 11 (3), pp.e1005062. ⟨10.1371/journal.pgen.1005062⟩

The trisomy of human chromosome 21 (Hsa21), which causes Down syndrome (DS), is the most common viable human aneuploidy. In contrast to trisomy, the complete monosomy (M21) of Hsa21 is lethal, and only partial monosomy or mosaic monosomy of Hsa21 is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfbc6dd75f2ea05c8681841f6ef103ab
https://hal-sde.archives-ouvertes.fr/hal-01323519

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