Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Karoly Szuhai"'
Autor:
Verónica Rey, Juan Tornín, Juan Jose Alba-Linares, Cristina Robledo, Dzohara Murillo, Aida Rodríguez, Borja Gallego, Carmen Huergo, Cristina Viera, Alejandro Braña, Aurora Astudillo, Dominique Heymann, Karoly Szuhai, Judith V.M.G. Bovée, Agustín F. Fernández, Mario F. Fraga, Javier Alonso, René Rodríguez
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105090- (2024)
Summary: Background: Sarcomas represent an extensive group of malignant diseases affecting mesodermal tissues. Among sarcomas, the clinical management of chondrosarcomas remains a complex challenge, as high-grade tumours do not respond to current the
Externí odkaz:
https://doaj.org/article/a9bcedfaab4940eeb62fdf6d5e65245e
Autor:
Wasifa Nurieva, Elena Ivanova, Sanabel Chehab, Parth Singh, Marina Reichlmeir, Karoly Szuhai, Georg W.J. Auburger, William C. Skarnes, Zoltán Ivics
Publikováno v:
Stem Cell Research, Vol 73, Iss , Pp 103247- (2023)
Ataxia-Telangiectasia (A-T) is an autosomal recessive multi-system disorder caused by mutations in the ataxia-telangiectasia mutated (ATM) gene, resulting, among other symptoms, in neurological dysfunction. ATM is known to be a master controller of s
Externí odkaz:
https://doaj.org/article/a0973d58e36c49e5aa49e8efd6f045f7
Autor:
Sheena L. M. Ong, Hans J. Baelde, David G. P. van IJzendoorn, Judith V. M. G. Bovée, Karoly Szuhai
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract There are no validated housekeeping genes in induced pluripotent stem cells (iPSC) and derived endothelial iPSC (iPSC-EC). Thus a comparison of gene expression levels is less reliable, especially during drug treatments. Here, we utilized tra
Externí odkaz:
https://doaj.org/article/dee09d61e46a4894b85a8e2f72672ac5
Autor:
Laura F. Ouboter, Marieke C. Barnhoorn, Hein W. Verspaget, Leonie Plug, Emma S. Pool, Karoly Szuhai, Lukas J.A.C. Hawinkels, Melissa van Pel, Jaap Jan Zwaginga, Dave Roelen, Frits Koning, M. Fernanda Pascutti, Andrea E. van der Meulen – de Jong
Publikováno v:
JCI Insight, Vol 8, Iss 9 (2023)
BACKGROUND Due to their immunoregulatory and tissue regenerative features, mesenchymal stromal cells (MSCs) are a promising novel tool for the management of ulcerative proctitis (UP). Here we report on a phase IIa clinical study that evaluated the im
Externí odkaz:
https://doaj.org/article/d46c7d397f5c473ea6322262d8153872
Autor:
Chloé Prunier, Ania Alay, Michiel van Dijk, Kelly L. Ammerlaan, Sharon van Gelderen, Dieuwke L. Marvin, Amina Teunisse, Roderick C. Slieker, Karoly Szuhai, A. G. Jochemsen, Xavier Solé, Peter ten Dijke, Laila Ritsma
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Reactivation of dormant cancer cells can lead to cancer relapse, metastasis, and patient death. Dormancy is a nonproliferative state and is linked to late relapse and death. No targeted therapy is currently available to eliminate dormant cel
Externí odkaz:
https://doaj.org/article/1a7695e25ac44d42a318fcdc5ab8c2ee
Autor:
Birgit Lohberger, Susanne Scheipl, Ellen Heitzer, Franz Quehenberger, Danielle de Jong, Karoly Szuhai, Bernadette Liegl-Atzwanger, Beate Rinner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Chordomas are rare slow growing, malignant bone tumors of the axial skeleton with no approved medical treatment. As the majority of chordomas express cMET and its ligand, HGF, and crosstalks between EGFR and MET-signaling exist, we aimed to
Externí odkaz:
https://doaj.org/article/8035117bd921477bb589f41c11a9927e
Autor:
Karim H Saba, Louise Cornmark, Jakob Hofvander, Linda Magnusson, Jenny Nilsson, Hilda van denBos, Diana CJ Spierings, Floris Foijer, Johan Staaf, Otte Brosjö, Vaiyapuri P Sumathi, Suk Wai Lam, Karoly Szuhai, Judith VMG Bovée, Michal Kovac, Daniel Baumhoer, Emelie Styring, Karolin H Nord
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 6, Iss 4, Pp 231-237 (2020)
Abstract Osteoblastoma is a locally aggressive tumour of bone. Until recently, its underlying genetic features were largely unknown. During the past two years, reports have demonstrated that acquired structural variations affect the transcription fac
Externí odkaz:
https://doaj.org/article/141e5b2fd24747968aaa611e5a7f1638
Autor:
Dorine C Hintzen, Mar Soto, Michael Schubert, Bjorn Bakker, Diana C J Spierings, Karoly Szuhai, Peter M Lansdorp, Roel J C Kluin, Floris Foijer, René H Medema, Jonne A Raaijmakers
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0268579 (2022)
Aneuploidy and chromosomal instability are both commonly found in cancer. Chromosomal instability leads to karyotype heterogeneity in tumors and is associated with therapy resistance, metastasis and poor prognosis. It has been hypothesized that aneup
Externí odkaz:
https://doaj.org/article/f584554feac24a5684cb7d0cfee58281
Autor:
Xueying Fan, Ioannis Moustakas, Vanessa Torrens-Juaneda, Qijing Lei, Geert Hamer, Leoni A Louwe, Gonneke S K Pilgram, Karoly Szuhai, Roberto Matorras, Cristina Eguizabal, Lucette van der Westerlaken, Hailiang Mei, Susana M Chuva de Sousa Lopes
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009773 (2021)
During gametogenesis in mammals, meiosis ensures the production of haploid gametes. The timing and length of meiosis to produce female and male gametes differ considerably. In contrast to males, meiotic prophase I in females initiates during developm
Externí odkaz:
https://doaj.org/article/cc6bb2ecaa424a22922367940bd877c2
Autor:
Renier C. Heijkants, Amina F. A. S. Teunisse, Danielle de Jong, Kseniya Glinkina, Hailiang Mei, Szymon M. Kielbasa, Karoly Szuhai, Aart G. Jochemsen
Publikováno v:
Cancers, Vol 14, Iss 18, p 4482 (2022)
The tumor suppressor protein p53 has an important role in cell-fate determination. In cancer cells, the activity of p53 is frequently repressed by high levels of MDMX and/or MDM2. MDM2 is a ubiquitin ligase whose activity results in ubiquitin- and pr
Externí odkaz:
https://doaj.org/article/dd3402b2c00149fcb12a271bc8c86d0e