Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Karoly Szekeres"'
Autor:
Nadine Nelson, Karoly Szekeres, Cristina Iclozan, Ivannie Ortiz Rivera, Andrew McGill, Gbemisola Johnson, Onyekachi Nwogu, Tomar Ghansah
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170197 (2017)
Pancreatic cancer (PC) evades immune destruction by favoring the development of regulatory T cells (Tregs) that inhibit effector T cells. The transcription factor Ikaros is critical for lymphocyte development, especially T cells. We have previously s
Externí odkaz:
https://doaj.org/article/f422de9d25b14847933d98db26bac17a
Murine pancreatic adenocarcinoma dampens SHIP-1 expression and alters MDSC homeostasis and function.
Autor:
Shari Pilon-Thomas, Nadine Nelson, Nasreen Vohra, Maya Jerald, Laura Pendleton, Karoly Szekeres, Tomar Ghansah
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27729 (2011)
Pancreatic cancer is one of the most aggressive cancers, with tumor-induced myeloid-derived suppressor cells (MDSC) contributing to its pathogenesis and ineffective therapies. In response to cytokine/chemokine receptor activation, src homology 2 doma
Externí odkaz:
https://doaj.org/article/925273efe2cb4adf9f130131eb1d6abc
Autor:
Richard, Thomson-Luque, Chengqi, Wang, Francis B, Ntumngia, Shulin, Xu, Karoly, Szekeres, Amy, Conway, Swamy Rakesh, Adapa, Samantha J, Barnes, John H, Adams, Rays H Y, Jiang
Publikováno v:
Blood Cells, Molecules & Diseases
Progress towards an in-depth understanding of the final steps of the erythroid lineage development is paramount for many hematological diseases. We have characterized the final stages of reticulocyte maturation from bone marrow to peripheral blood us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2a0cac1e3d2a4c025902d775607940b6
https://pubmed.ncbi.nlm.nih.gov/30007855
https://pubmed.ncbi.nlm.nih.gov/30007855
Autor:
Govind Ragupathi, Dana Odukoya, Sanjai Kumar, Francesca Blazekovic, Erika Puleo, George Blanck, Shanitra N. Butler, Karoly Szekeres, Dibyendu Dana, James A. Mauro, Michael Ramsamooj
Publikováno v:
Human Vaccines & Immunotherapeutics. 12:593-598
HLA-DR is the most commonly expressed and likely the most medically important human MHC class II, antigen presenting protein. In a normal immune response, HLA-DR binds to antigenic peptide and the HLA-DR/peptide complex binds to a T-cell receptor, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a815980e9a00234d2c9a92afa12e30
https://doi.org/10.1080/21645515.2015.1089370
https://doi.org/10.1080/21645515.2015.1089370
Publikováno v:
Experimental and Molecular Pathology. 97:585-589
A continuing conundrum of cancer biology is the dichotomous function of transcription factors that regulate both proliferation and apoptosis, seemingly opposite results. Previous results have indicated that regulated entry into the S-phase of the cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1155feface4048e5d660193fc0147d
https://doi.org/10.1016/j.yexmp.2014.09.010
https://doi.org/10.1016/j.yexmp.2014.09.010
Autor:
Hernando Escobar, Eduardo Reyes-Vargas, Mark C. Lloyd, Kevin Cronin, George Blanck, Alan L. Rockwood, Julio C. Delgado, Karoly Szekeres
Publikováno v:
Human Vaccines & Immunotherapeutics. 9:784-789
Numerous molecular effects have been attributed to histone deacetylase inhibitors (HDACI's), including the induction of major histocompatibility (MHC) genes. Here we report that one FDA approved HDACI, Vorinostat, and a second HDACI currently in clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada0a112f8ad521f0ee2633133741755
https://doi.org/10.4161/hv.23085
https://doi.org/10.4161/hv.23085
Autor:
Nadine Nelson, Ivannie Ortiz Rivera, Tomar Ghansah, Gbemisola Johnson, Onyekachi Nwogu, Andrew R. McGill, Cristina Iclozan, Karoly Szekeres
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 2, p e0170197 (2017)
PLoS ONE, Vol 12, Iss 2, p e0170197 (2017)
Pancreatic cancer (PC) evades immune destruction by favoring the development of regulatory T cells (Tregs) that inhibit effector T cells. The transcription factor Ikaros is critical for lymphocyte development, especially T cells. We have previously s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2dccf48ea10b4c8b1894c4200375d5c
https://pubmed.ncbi.nlm.nih.gov/28152014
https://pubmed.ncbi.nlm.nih.gov/28152014
Publikováno v:
Anticancer research. 35(1)
Melanoma cells express high levels of HLA class II, cell surface antigen-presenting proteins, which is an anomalous phenotype among solid tumors. There has never been a satisfying explanation for how this HLA class II-positive phenotype is related to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eca73cd0906c5d596ecad77522f08324
https://pubmed.ncbi.nlm.nih.gov/25550531
https://pubmed.ncbi.nlm.nih.gov/25550531
Autor:
Kenneth V. Honn, Keqin Tang, Daotai Nie, Karoly Szekeres, Mario Lamberti, Alex Zacharek, YuChyu Chen, Li Li
Publikováno v:
Biochemical and Biophysical Research Communications. 267:245-251
Prostaglandin endoperoxide H synthases and their arachidonate products have been implicated in modulating angiogenesis during tumor growth and chronic inflammation. Here we report the involvement of thromboxane A(2), a downstream metabolite of prosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a33d9d39e943d2707f3235ffb18de2d
https://doi.org/10.1006/bbrc.1999.1840
https://doi.org/10.1006/bbrc.1999.1840
Publikováno v:
Clinical and Experimental Metastasis. 16:437-445
In resting platelets integrin αIibβ3 is constitutively expressed in an inactive state and it does not recognize soluble proteins. Platelet activation results in a conformational change of the low-affinity αIibβ3 to a high-affinity state which the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ccae636185b89c24d4d23b654619fd9
https://doi.org/10.1023/a:1006533508560
https://doi.org/10.1023/a:1006533508560