Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Karoly Mirnics"'
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 410 (2024)
Cholesterol is an essential molecule of life, and its synthesis can be inhibited by both genetic and nongenetic mechanisms. Hundreds of chemicals that we are exposed to in our daily lives can alter sterol biosynthesis. These also encompass various cl
Externí odkaz:
https://doaj.org/article/517b6a0851d84a83bb1128a78706c3e1
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1321 (2023)
The concurrent use of several medications is a common practice in the treatment of complex psychiatric conditions. One such commonly used combination is aripiprazole (ARI), an antipsychotic, and trazodone (TRZ), an antidepressant. In addition to thei
Externí odkaz:
https://doaj.org/article/708e78d3b07c4f98ba77747e9078cad8
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 8, Pp 100249- (2022)
Polypharmacy, or the simultaneous use of multiple drugs to treat a single patient, is a common practice in psychiatry. Unfortunately, data on the health effects of commonly used combinations of medications are very limited. In this study, we therefor
Externí odkaz:
https://doaj.org/article/0097b70b7532453c88d7285e8fbd493f
Autor:
Zeljka Korade, Luke B. Allen, Allison Anderson, Keri A. Tallman, Thiago C. Genaro-Mattos, Ned A. Porter, Karoly Mirnics
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Trazodone (TRZ) is a commonly prescribed antidepressant with significant off-label use for insomnia. A recent drug screening revealed that TRZ interferes with sterol biosynthesis, causing elevated levels of sterol precursor 7-dehydrocholeste
Externí odkaz:
https://doaj.org/article/67ed1de6baf7469e8270dfd73a93f59e
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Background: MicroRNAs (miRNAs) may be promising therapeutic targets for neonatal hypoxic-ischemic brain injury (HIBI) but targeting miRNA-based therapy will require more precise understanding of endogenous brain miRNA expression.Methods: Postnatal da
Externí odkaz:
https://doaj.org/article/3cedae2584a84dc784965b1a20193a3d
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1535 (2022)
Polypharmacy is commonly used to treat psychiatric disorders. These combinations often include drugs with sterol biosynthesis inhibiting side effects, including the antipsychotic aripiprazole (ARI), and antidepressant trazodone (TRZ). As the effects
Externí odkaz:
https://doaj.org/article/cd92b40896fc4fddb454e27d60e2f7a4
Autor:
Venugopal Gunda, Thiago C. Genaro-Mattos, Jyoti B. Kaushal, Ramakanth Chirravuri-Venkata, Gopalakrishnan Natarajan, Kavita Mallya, Paul M. Grandgenett, Karoly Mirnics, Surinder K. Batra, Zeljka Korade, Satyanarayana Rachagani
Publikováno v:
Metabolites, Vol 12, Iss 1, p 47 (2022)
Pancreatic cancer (PC) is characterized by metabolic deregulations that often manifest as deviations in metabolite levels and aberrations in their corresponding metabolic genes across the clinical specimens and preclinical PC models. Cholesterol is o
Externí odkaz:
https://doaj.org/article/59e26ebcfb55434f8d9198cdd707ce65
Autor:
Matthew Schwede, Shailender Nagpal, Michael J. Gandal, Neelroop N. Parikshak, Karoly Mirnics, Daniel H. Geschwind, Eric M. Morrow
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 10, Iss 1, Pp 1-9 (2018)
Abstract Background Genetic studies in autism have pinpointed a heterogeneous group of loci and genes. Further, environment may be an additional factor conferring susceptibility to autism. Transcriptome studies investigate quantitative differences in
Externí odkaz:
https://doaj.org/article/a43d93e689e243578493a25a6b22a5a9
Autor:
Zeljka Korade, Thiago C. Genaro-Mattos, Keri A. Tallman, Wei Liu, Krassimira A. Garbett, Katalin Koczok, Istvan Balogh, Karoly Mirnics, Ned A. Porter
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 11, Pp 2139-2146 (2017)
Smith-Lemli-Opitz syndrome is a recessive disorder caused by mutations in 7-dehydrocholesterol reductase (DHCR)7 with a heterozygous (HET) carrier frequency of 1–3%. A defective DHCR7 causes accumulation of 7-dehydrocholesterol (DHC), which is a hi
Externí odkaz:
https://doaj.org/article/fa4381a31948402ab99163f966358465
Autor:
Amanda C. Mitchell, Behnam Javidfar, Lucy K. Bicks, Rachael Neve, Krassimira Garbett, Sharon S. Lander, Karoly Mirnics, Hirofumi Morishita, Marcelo A. Wood, Yan Jiang, Inna Gaisler-Salomon, Schahram Akbarian
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Chromosome conformation is a dynamic process, especially in brain. Here, Mitchell and colleagues devise a method they call NeuroDam that can prospectively tag chromosome conformation in the mouse brain in vivo, and longitudinally assess long range ch
Externí odkaz:
https://doaj.org/article/f253420b0f734648a73d3166c76192e2