Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Karoline T, Neumann"'
1
Akademický článek
Efficient palladium-catalyzed electrocarboxylation enables late-stage carbon isotope labelling
Autor: Gabriel M. F. Batista, Ruth Ebenbauer, Craig Day, Jonas Bergare, Karoline T. Neumann, Kathrin H. Hopmann, Charles S. Elmore, Alonso Rosas-Hernández, Troels Skrydstrup
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Carbon isotope labelling of bioactive molecules is essential for accessing the pharmacokinetic and pharmacodynamic properties of new drug entities. Aryl carboxylic acids represent an important class of structural motifs ubiquitous in pharmac
Externí odkaz: https://doaj.org/article/e1563e8495164d6896ba652adba48920
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3
Nickel-Catalyzed Carbonylative Coupling of Alkylzinc Reagents and α-Bromo-α,α-difluoroacetamides
Autor: Troels Skrydstrup, Karoline T. Neumann, Nicklas P. Corneliussen, Ebbe K. Grove, Anne-Sofie O. Schøler, Anton H. Andersen, Aske S. Donslund
Publikováno v: Corneliussen, N P, Grove, E K, Scholer, A S O, Andersen, A, Donslund, A S, Neumann, K T & Skrydstrup, T 2023, ' Nickel-Catalyzed Carbonylative Coupling of Alkylzinc Reagents and α-Bromo-α,α-difluoroacetamides ', Synlett . https://doi.org/10.1055/a-2036-4809
We report a nickel-catalyzed carbonylative cross-coupling of alkyl zinc reagents with α,α-difluorobromoacetamides to obtain α,α,-difluoro-β-ketoamides in moderate to good yields. The reaction is catalyzed by a bench-stable nickel(II) pincer comp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb61342dca46130cc058b68f8d278a02
https://pure.au.dk/portal/da/publications/nickelcatalyzed-carbonylative-coupling-of-alkylzinc-reagents-and-bromodifluoroacetamides(7df8f633-ccd0-482f-af8d-2e054e99757c).html
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4
Akademický článek
New Directions in Transition Metal Catalyzed Carbonylation Chemistry
Autor: Dennis U. Nielsen, Karoline T. Neumann, Troels Skrydstrup
Publikováno v: CHIMIA, Vol 72, Iss 9 (2018)
Carbon monoxide (CO) represents an important C1-building block for the construction of some of the most fundamental chemical functionalities carrying a carbon–oxygen double bond. Transition metal catalysis plays a key role in promoting such transfo
Externí odkaz: https://doaj.org/article/232b865697e24c928be3fe450b9e8d1f
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6
Access to β‐Ketonitriles through Nickel‐Catalyzed Carbonylative Coupling of α‐Bromonitriles with Alkylzinc Reagents
Autor: Karoline T. Neumann, Troels Skrydstrup, Nicklas P. Corneliussen, Aske S. Donslund, Kim Daasbjerg, Domenique Herbstritt, Ebbe K. Grove
Publikováno v: Donslund, A S, Neumann, K T, Corneliussen, N P, Grove, E K, Herbstritt, D, Daasbjerg, K & Skrydstrup, T 2019, ' Access to β-Ketonitriles through Nickel-Catalyzed Carbonylative Coupling of α-Bromonitriles with Alkylzinc Reagents ', Chemistry-A European Journal, vol. 25, no. 42, pp. 9856-9860 . https://doi.org/10.1002/chem.201902206
Herein, we report a nickel-catalyzed carbonylative coupling of α-bromonitriles and alkylzinc reagents with near stoichiometric carbon monoxide to give β-ketonitriles in good yields. The reaction is catalyzed by a readily available and stable nickel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f7ecbb7f764e10c8655dc08be9af50
https://doi.org/10.1002/chem.201902206
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7
Synthesis of Aliphatic Carboxamides Mediated by Nickel NN2 -Pincer Complexes and Adaptation to Carbon-Isotope Labeling
Autor: Karoline T. Neumann, Thomas Levin Andersen, Troels Skrydstrup, Aske S. Donslund, Dennis U. Nielsen
Publikováno v: Neumann, K T, Donslund, A S, Andersen, T, Nielsen, D U & Skrydstrup, T 2018, ' Synthesis of Aliphatic Carboxamides Mediated by Nickel NN 2-Pincer Complexes and Adaption to Carbon Isotope-Labeling ', Chemistry-A European Journal, vol. 24, no. 56, pp. 14946-14949 . https://doi.org/10.1002/chem.201804077
The development of a nickel-mediated aminocarbonylation utilizing NN2 -pincer Ni-complexes, alkylzinc reagents, stoichiometric carbon monoxide and amines is described for the first time, which can be adapted to late-stage carbon-isotope labeling. Thi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82742fb19adaef3ae7bcc2a10d2ea9b2
https://doi.org/10.1002/chem.201804077
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8
Recent developments in carbonylation chemistry using [13C]CO, [11C]CO, and [14C]CO
Autor: Dennis U. Nielsen, Troels Skrydstrup, Anders T. Lindhardt, Karoline T. Neumann
Publikováno v: Nielsen, D U, Neumann, K T, Lindhardt, A T & Skrydstrup, T 2018, ' Recent developments in carbonylation chemistry using [ 13 C]CO, [ 11 C]CO, and [ 14 C]CO ', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 61, no. 13, pp. 949-987 . https://doi.org/10.1002/jlcr.3645
Carbon monoxide represents the most important C1-building block for the chemical industry, both for the production of bulk and fine chemicals, but also for synthetic fuels. Yet its toxicity and subsequently its cautious handling have limited its appl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37e839dd5ea79b13b3ff0400deb15c4
https://doi.org/10.1002/jlcr.3645
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9
Direct Access to Isotopically Labeled Aliphatic Ketones Mediated by Nickel(I) Activation
Autor: Cecilie Gaardbo, Charles S. Elmore, Simon S. Pedersen, Aske S. Donslund, Lee P. Kingston, Karoline T. Neumann, Troels Skrydstrup
Publikováno v: Donslund, A S, Pedersen, S S, Gaardbo, C, Neumann, K T, Kingston, L, Elmore, C S & Skrydstrup, T 2020, ' Direct Access to Isotopically Labeled Aliphatic Ketones Mediated by Nickel(I) Activation ', Angewandte Chemie-International Edition, vol. 59, no. 21, pp. 8099-8103 . https://doi.org/10.1002/anie.201916391
An extensive range of functionalized aliphatic ketones with good functional-group tolerance has been prepared by a NiI-promoted coupling of either primary or secondary alkyl iodides with NN2 pincer NiII-acyl complexes. The latter were easily accessed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810c712c8b301dc953ea66cfd8c8af93
https://pubmed.ncbi.nlm.nih.gov/32017346
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10
Direct trans-Selective Ruthenium-Catalyzed Reduction of Alkynes in Two-Chamber Reactors and Continuous Flow
Autor: Benny Bang-Andersen, Troels Skrydstrup, Sebastian Klimczyk, Mia N. Burhardt, Anders T. Lindhardt, Karoline T. Neumann
Publikováno v: Neumann, K T, Klimczyk, S, Burhardt, M, Bang-Andersen, B, Skrydstrup, T & Lindhardt, A T 2016, ' Direct trans-Selective Ruthenium-Catalyzed Reduction of Alkynes in Two-Chamber Reactors and Continuous Flow ', ACS Catalysis, vol. 6, no. 7, pp. 4710-4714 . https://doi.org/10.1021/acscatal.6b01045
An efficient trans-selective hydrogenation of alkynes under low hydrogen pressure and low reaction temperatures is reported, applying a commercially available ruthenium hydride complex. The developed reaction conditions, which tolerate a variety of f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23892078cd336d33ed73709559392f3c
https://doi.org/10.1021/acscatal.6b01045
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